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    IMMUNOGENIC BACTERIAL VESICLES WITH OUTER MEMBRANE PROTEINS
    1.
    发明申请
    IMMUNOGENIC BACTERIAL VESICLES WITH OUTER MEMBRANE PROTEINS 有权
    具有外膜蛋白的免疫细菌性细菌

    公开(公告)号：US20160108094A1

    公开(公告)日：2016-04-21

    申请号：US14927052

    申请日：2015-10-29

    Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

    Inventor： Jeannette ADU-BOBIE ,  Mariagrazia PIZZA ,  Nathalie NORAIS ,  Germano FERRARI ,  Guido GRANDI

    IPC: C07K14/245 ,  C07K14/22

    CPC classification number: C07K14/245 ,  A61K39/00 ,  A61K39/0258 ,  A61K39/095 ,  C07K14/22 ,  C12N9/1051 ,  Y02A50/474

    Abstract: Knockout of the meningococcal mltA homolog gives bacteria that spontaneously release vesicles that are rich in immunogenic outer membrane proteins and that can elicit cross-protective antibody responses with higher bactericidal titres than OMVs prepared by normal production processes. Thus the invention provides a bacterium having a knockout mutation of its mltA gene. The invention also provides a bacterium, wherein the bacterium: (i) has a cell wall that includes peptidoglycan; and (ii) does not express a protein having the lytic transglycosylase activity MltA protein. The invention also provides compositions comprising vesicles that, during culture of bacteria of the invention, are released into the culture medium.

    Abstract translation: 脑膜炎球菌mltA同系物的敲除使细菌自发释放富含免疫原性外膜蛋白的囊泡，并且能够以比正常生产过程制备的OMV更高的杀菌滴度引发交叉保护性抗体应答。 因此，本发明提供了具有其mltA基因的敲除突变的细菌。 本发明还提供了一种细菌，其中所述细菌：（i）具有包含肽聚糖的细胞壁; 和（ii）不表达具有溶解性转糖苷酶活性MltA蛋白质的蛋白质。 本发明还提供包含囊泡的组合物，其在本发明的细菌培养期间释放到培养基中。

    MULTIPLE VARIANTS OF MENINGOCOCCAL PROTEIN NMB1870
    2.
    发明申请
    MULTIPLE VARIANTS OF MENINGOCOCCAL PROTEIN NMB1870 有权
    多功能蛋白质NMB1870变体

    公开(公告)号：US20160039887A1

    公开(公告)日：2016-02-11

    申请号：US14918417

    申请日：2015-10-20

    Applicant: GlaxoSmithKline Biologicals SA

    Inventor： Maurizio COMANDUCCI ,  Mariagrazia PIZZA

    IPC: C07K14/22 ,  A61K39/102 ,  C07K14/285 ,  A61K39/39 ,  A61K39/095

    CPC classification number: A61K39/095 ,  A61K39/102 ,  A61K39/39 ,  A61K2039/55505 ,  A61K2039/575 ,  C07K14/22 ,  C07K14/285 ,  C07K2319/00

    Abstract: Meningococcal protein NMB 1870 has been described in the prior art. The inventors have found that NMB 1870 is an effective antigen for eliciting anti-meningococcal antibody responses, and that it is expressed across all meningococcal serogroups. Forty-two different NMB 1870 sequences have been identified, and these group into three variants. Serum raised against a given variant is bactericidal within the same variant group, but is not active against strains which express one of the other two variants i.e. there is intra-variant cross-protection, but not inter-variant cross-protection. For maximum cross-strain efficacy, therefore, the invention uses mixture comprising different variants of NMB 1870.

    Abstract translation: 脑膜炎球菌蛋白NMB1870已经在现有技术中描述。 本发明人已经发现NMB1870是用于引发抗脑膜炎球菌抗体应答的有效抗原，并且其在所有脑膜炎球菌血清群中表达。 已经确定了42种不同的NMB 1870序列，并且这些序列分为三个变体。 针对给定变体产生的血清在同一变体组内是杀菌的，但对于表达其它两种变体之一的菌株不具有活性，即存在变异体内的交叉保护，而不是变异体间交叉保护。 因此，为了获得最大的交叉应变效能，本发明使用包含NMB1870不同变体的混合物。

    IMMUNOGENIC COMPOSITIONS
    3.
    发明申请
    IMMUNOGENIC COMPOSITIONS 有权

    公开(公告)号：US20250049906A1

    公开(公告)日：2025-02-13

    申请号：US18894961

    申请日：2024-09-24

    Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

    Inventor： Mario CONTORNI ,  Mariagrazia PIZZA ,  Anja SEUBERT

    IPC: A61K39/00 ,  A61P31/04

    Abstract: The invention provides an immunogenic composition comprising OMVs and (a) acellular pertussis antigen, (b) a tetanus toxoid and (c) a diphtheria toxoid, wherein the OMVs are derived from Bordetella pertussis. The invention also provides compositions for use in a method for raising an immune response in a patient, comprising the step of administering to the patient a composition of the invention.

    NEISSERIAL ANTIGENIC PEPTIDES
    7.
    发明申请
    NEISSERIAL ANTIGENIC PEPTIDES 审中-公开
    NEISSERIAL抗原肽

    公开(公告)号：US20160051658A1

    公开(公告)日：2016-02-25

    申请号：US14750837

    申请日：2015-06-25

    Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

    Inventor： Cesira GALEOTTI ,  Guido GRANDI ,  Vega MASIGNANI ,  Marirosa MORA ,  Mariagrazia PIZZA ,  Rino RAPPUOLI ,  Giulio RATTI ,  Vincenzo SCARLATO ,  Maria SCARSELLI

    IPC: A61K39/095

    CPC classification number: A61K39/095 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/55505 ,  C07K14/22

    Abstract: This invention provides, among other things, proteins, polypeptides, and fragments thereof, derived from the bacteria Neisseria meningitidis B. Also provided are nucleic acids encoding for such proteins, polypeptides, and/or fragments, as well as nucleic acids complementary thereto e.g., antisense nucleic acids). Additionally, this invention provides antibodies which bind to the proteins, polypeptides, and/or fragments. This invention further provides expression vectors useful for making the proteins, polypeptides, and/or fragments, as well as host cells transformed with such vectors. This invention also provides compositions of the proteins, polypeptides, fragments, and/or nucleic acids, for use as vaccines, diagnostic reagents, immunogenic compositions, and the like. Methods of making the compositions and methods of treatment with the compositions are also provided. This invention also provides methods of detecting the proteins, polypeptides, fragments, and/or nucleic acids.

    Abstract translation: 本发明尤其提供衍生自脑膜炎奈瑟氏球菌B细菌的蛋白质，多肽和其片段。还提供编码这种蛋白质，多肽和/或片段的核酸，以及与其互补的核酸，例如， 反义核酸）。 另外，本发明提供了结合蛋白质，多肽和/或片段的抗体。 本发明进一步提供了可用于制备蛋白质，多肽和/或片段以及用这些载体转化的宿主细胞的表达载体。 本发明还提供用作疫苗，诊断试剂，免疫原性组合物等的蛋白质，多肽，片段和/或核酸的组合物。 还提供了用组合物制备组合物和处理方法的方法。 本发明还提供了检测蛋白质，多肽，片段和/或核酸的方法。

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