公开(公告)号：US11986518B2

公开(公告)日：2024-05-21

申请号：US16985979

申请日：2020-08-05

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Christiane Gerke ,  Laura Bartle Martin ,  Allan James Saul

IPC: A61K39/112 ,  A61K39/00

CPC classification number: A61K39/0283 ,  A61K2039/55505 ,  A61K2039/55572 ,  A61K2039/70 ,  Y02A50/30

Abstract: This invention relates to immunogenic compositions, particularly vaccine compositions, for use in providing protection against illness caused by bacterial infection with Shigella strains.

公开(公告)号：US11339367B2

公开(公告)日：2022-05-24

申请号：US15094077

申请日：2016-04-08

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Christiane Gerke ,  Francesco Berlanda Scorza ,  Allan Saul ,  Luana Maggiore

IPC: C12N1/20 ,  C07K14/25 ,  A61K39/00 ,  A61K35/12

Abstract: Hyperblebbing Shigella strains are generated by disrupting one or more components of the Tol-Pal system. The blebs from these strains are useful immunogens for vaccination. The individual proteins found in these blebs can also be used as immunogens.