公开(公告)号：US10603369B2

公开(公告)日：2020-03-31

申请号：US15887203

申请日：2018-02-02

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Barbara Baudner ,  David Skibinski ,  Manmohan Singh ,  Derek O'Hagan

IPC: A61K39/00 ,  A61K31/4375 ,  A61K31/66 ,  A61K33/06 ,  A61K39/39 ,  A61K39/12 ,  A61K39/102 ,  A61K39/116 ,  A61K39/295

Abstract: Combination vaccine compositions as well as methods for their manufacture have a relatively low amount of antigen and/or a relatively low amount of aluminium, but they can nevertheless have immunogenicity which is comparable to combination vaccines with a relatively high amount of antigen and/or a relatively high amount of aluminium. Aluminium-free combination vaccine compositions are also provided e.g. compositions which are adjuvanted with an oil-in-water emulsion adjuvant.

公开(公告)号：US20160375132A1

公开(公告)日：2016-12-29

申请号：US15201651

申请日：2016-07-05

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： David Skibinski ,  Siddhartha Jain ,  Manmohan Singh ,  Derek O'Hagan

IPC: A61K39/39 ,  A61K39/12 ,  A61K31/4745 ,  A61K39/095 ,  A61K39/155

CPC classification number: A61K39/39 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/675 ,  A61K31/683 ,  A61K31/7004 ,  A61K31/717 ,  A61K39/095 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55566 ,  C12N2760/14134 ,  C12N2760/18534 ,  Y02A50/41 ,  A61K2300/00

Abstract: The present invention generally relates to homogeneous suspensions of small molecule immune potentiators (SMIPs) that are capable of stimulating or modulating an immune response in a subject in need thereof. The homogeneous suspensions may be used in combinations with various antigens or adjuvants for vaccine therapies.