公开(公告)号：US10046048B2

公开(公告)日：2018-08-14

申请号：US15201651

申请日：2016-07-05

Applicant: GlaxoSmithKline Biologicals SA

Inventor： David Skibinksi ,  Siddhartha Jain ,  Manmohan Singh ,  Derek O'Hagan

IPC: A61K39/39 ,  A61K31/4745 ,  A61K31/7004 ,  A61K31/717 ,  A61K39/095 ,  A61K39/155 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/675 ,  A61K31/683 ,  A61K39/12 ,  A61K39/00

Abstract: The present invention generally relates to homogeneous suspensions of small molecule immune potentiators (SMIPs) that are capable of stimulating or modulating an immune response in a subject in need thereof. The homogeneous suspensions may be used in combinations with various antigens or adjuvants for vaccine therapies.

公开(公告)号：US09795668B2

公开(公告)日：2017-10-24

申请号：US14948908

申请日：2015-11-23

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Siddhartha Jain ,  Manmohan Singh ,  Derek O'Hagan

IPC: A61K39/385 ,  C12Q1/68 ,  A61K9/16 ,  A61K9/51 ,  A61K39/155 ,  C12N15/86 ,  C12N15/88 ,  A61K39/12 ,  A61K39/00

CPC classification number: A61K39/385 ,  A61K9/1617 ,  A61K9/1647 ,  A61K9/5123 ,  A61K9/5153 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/55555 ,  A61K2039/622 ,  A61P31/14 ,  C12N15/86 ,  C12N15/88 ,  C12N2760/18534 ,  C12N2770/36143

Abstract: Particle compositions comprising adsorbed RNA replicons as well as methods of making and using the same are described.

公开(公告)号：US20160375132A1

公开(公告)日：2016-12-29

申请号：US15201651

申请日：2016-07-05

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： David Skibinski ,  Siddhartha Jain ,  Manmohan Singh ,  Derek O'Hagan

IPC: A61K39/39 ,  A61K39/12 ,  A61K31/4745 ,  A61K39/095 ,  A61K39/155

CPC classification number: A61K39/39 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/675 ,  A61K31/683 ,  A61K31/7004 ,  A61K31/717 ,  A61K39/095 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55566 ,  C12N2760/14134 ,  C12N2760/18534 ,  Y02A50/41 ,  A61K2300/00

Abstract: The present invention generally relates to homogeneous suspensions of small molecule immune potentiators (SMIPs) that are capable of stimulating or modulating an immune response in a subject in need thereof. The homogeneous suspensions may be used in combinations with various antigens or adjuvants for vaccine therapies.

公开(公告)号：US20180280301A1

公开(公告)日：2018-10-04

申请号：US15981104

申请日：2018-05-16

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： Derek O'Hagan ,  Manmohan Singh ,  Siddhartha Jain ,  Padma Malyala

IPC: A61K9/14 ,  A61K39/095 ,  A61J1/00 ,  A61K39/00

Abstract: In one aspect, the present invention provides sterile microparticle compositions comprising biodegradable microparticles, which comprise at least one biodegradable polymer. In other aspects, the present invention provides methods of making and using such compositions as well as articles of manufacture and kits containing the same.