公开(公告)号：US11944675B2

公开(公告)日：2024-04-02

申请号：US17061687

申请日：2020-10-02

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Fabiana Fernandez ,  Michael Kowarik ,  Michael Wacker ,  Michael Wetter

IPC: A61K39/112 ,  A61K39/00 ,  A61K39/02 ,  A61K39/104 ,  A61K39/108 ,  A61K39/385 ,  C07K14/195

CPC classification number: A61K39/0283 ,  A61K39/0258 ,  A61K39/104 ,  A61K39/105 ,  A61K39/385 ,  C07K14/195 ,  A61K2039/6037 ,  A61K2039/6068 ,  A61K2039/6087 ,  C07K2319/034 ,  Y02A50/30

Abstract: The present invention is directed to a bioconjugate vaccine, such as an O 1-bioconjugate vaccine, comprising: a protein carrier comprising a protein carrier containing at least one consensus sequence, DIE-X-N-Z-S/T, wherein X and Z may be any natural amino acid except proline; at least one antigenic polysaccharide from at least one pathogenic bacterium, linked to the protein carrier; and, optionally, an adjuvant. In another aspect, the present invention is directed to a method of producing an O 1-bioconjugate in a bioreactor comprising a number steps.