公开(公告)号：US10195262B2

公开(公告)日：2019-02-05

申请号：US15101626

申请日：2014-12-03

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Michael Wacker ,  Michael Kowarik ,  Michael Wetter

IPC: A61K39/085 ,  A61K39/40 ,  A61K39/00

Abstract: Provided herein are immunogenic compositions and vaccines for the treatment and prevention of Staphylococcus aureus infections. These immunogenic compositions and vaccines comprise combinations of bioconjugates capsular polysaccharides that are N-linked to one or more carrier proteins.

公开(公告)号：US10973901B2

公开(公告)日：2021-04-13

申请号：US16034906

申请日：2018-07-13

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Michael Wacker ,  Michael Kowarik ,  Michael Wetter ,  Amirreza Faridmoayer

IPC: A61K39/085 ,  A61K39/09 ,  C12N15/70 ,  C12P21/00 ,  A61K39/00

Abstract: Provided herein are prokaryotic cells proficient to produce glycoconjugates in vivo, as well as methods for generating these cell and methods of using these cells to produce glycoconjugates. The compositions of the mentioned glycoconjugates as well as their different uses are also included.

公开(公告)号：US11944675B2

公开(公告)日：2024-04-02

申请号：US17061687

申请日：2020-10-02

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Fabiana Fernandez ,  Michael Kowarik ,  Michael Wacker ,  Michael Wetter

IPC: A61K39/112 ,  A61K39/00 ,  A61K39/02 ,  A61K39/104 ,  A61K39/108 ,  A61K39/385 ,  C07K14/195

CPC classification number: A61K39/0283 ,  A61K39/0258 ,  A61K39/104 ,  A61K39/105 ,  A61K39/385 ,  C07K14/195 ,  A61K2039/6037 ,  A61K2039/6068 ,  A61K2039/6087 ,  C07K2319/034 ,  Y02A50/30

Abstract: The present invention is directed to a bioconjugate vaccine, such as an O 1-bioconjugate vaccine, comprising: a protein carrier comprising a protein carrier containing at least one consensus sequence, DIE-X-N-Z-S/T, wherein X and Z may be any natural amino acid except proline; at least one antigenic polysaccharide from at least one pathogenic bacterium, linked to the protein carrier; and, optionally, an adjuvant. In another aspect, the present invention is directed to a method of producing an O 1-bioconjugate in a bioreactor comprising a number steps.