公开(公告)号：US20240383949A1

公开(公告)日：2024-11-21

申请号：US18435026

申请日：2024-02-07

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Enrico MALITO ,  Matthew James BOTTOMLEY ,  Andrea CARFI ,  Sumana CHANDRAMOULI ,  Kate LUISI

IPC: C07K14/045 ,  A61K38/00 ,  A61K39/245

Abstract: Described are mutant human cytomegalovirus (HCMV) pentamer complex polypeptides, methods of making them, and their use in HCMV protein complexes and compositions. In particular, the use of the modified HCMV polypeptides to stabilize HCMV complexes or unmask a pentamer epitope is described.

公开(公告)号：US20210277067A1

公开(公告)日：2021-09-09

申请号：US17223207

申请日：2021-04-06

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Enrico MALITO ,  Matthew James BOTTOMLEY ,  Andrea CARFI ,  Sumana CHANDRAMOULI ,  Kate LUISI

IPC: C07K14/045 ,  A61K39/245 ,  A61K38/00

Abstract: Described are mutant human cytomegalovirus (HCMV) pentamer complex polypeptides, methods of making them, and their use in HCMV protein complexes and compositions. In particular, the use of the modified HCMV polypeptides to stabilize HCMV complexes or unmask a pentamer epitope is described.

公开(公告)号：US20200172930A1

公开(公告)日：2020-06-04

申请号：US16631557

申请日：2018-07-19

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Benjamin WIZEL ,  Martine HARVEY ,  Lucile WARTER ,  Kate LUISI

IPC: C12N15/86 ,  A61K39/12

Abstract: The invention provides adenoviral vectors comprising transgenes encoding Chikungunya virus antigens. The vectors can be used to produce vaccines for the prophylaxis, amelioration and treatment of diseases caused by Chikungunya virus infections.

公开(公告)号：US20230364219A1

公开(公告)日：2023-11-16

申请号：US17918676

申请日：2021-04-16

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Dong YU ,  Giulietta MARUGGI ,  Jason W. WESTERBECK ,  Jeffrey B. ULMER ,  Jason P. LALIBERTE ,  Kate LUISI ,  Lin QU

IPC: A61K39/215 ,  A61P37/04

CPC classification number: A61K39/215 ,  A61P37/04 ,  A61K2039/55566

Abstract: Compounds useful as components of immunogenic compositions for the induction of an immunogenic response in a subject against infection, methods for their use in treatment, and processes for their manufacture are provided herein. The compounds comprise a nucleic acid construct comprising a sequence which encodes an antigen, in particular a Coronavirus antigen.

公开(公告)号：US20230174626A1

公开(公告)日：2023-06-08

申请号：US17913264

申请日：2021-03-25

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Marco BIANCUCCI ,  Sumana CHANDRAMOULI ,  Kate LUISI

IPC: C07K16/08 ,  G01N33/569

CPC classification number: C07K16/088 ,  G01N33/56994 ,  C07K2317/24 ,  C07K2317/565

Abstract: Monoclonal antibodies and antigen binding fragments that specifically bind to the Human Cytomegalovirus (HCMV) pentamer protein complex (gH/gL/UL128/UL130/UL131A) or other gH-containing complexes, and uses thereof.