公开(公告)号：US12128096B2

公开(公告)日：2024-10-29

申请号：US17804679

申请日：2022-05-31

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Amirreza Faridmoayer ,  Rainer Follador ,  Stefan Jochen Kemmler ,  Michael Thomas Kowarik ,  Gerald Johann Posch ,  Fabio Serventi

IPC: A61K39/09 ,  A61K39/102 ,  C08B37/00 ,  A61K35/74 ,  A61K38/00 ,  A61K47/36 ,  B01J20/32 ,  C07K9/00 ,  C07K14/315

CPC classification number: A61K39/092 ,  A61K39/102 ,  C08B37/006 ,  A61K35/74 ,  A61K38/00 ,  A61K47/36 ,  B01J20/32 ,  C07K9/005 ,  C07K14/315

Abstract: The disclosure provides synthetic (e.g. recombinant) pneumococcal saccharides comprising one or more repeat unit(s) →4)-β-D-Glcp-(1→4)-[Gro-(2→P→3)]-β-D-Galp-(1→4)-β-L-Rhap-(1→. Also provided are conjugates comprising a →4)-β-D-Glcp-(1→4)-[Gro-(2→P→3)]-β-D-Galp-(1→4)-β-L-Rhap-(1→, immunogenic compositions, vaccines and their use in preventing or treating infection by Streptococcus pneumoniae.

公开(公告)号：US11654190B2

公开(公告)日：2023-05-23

申请号：US16620911

申请日：2018-07-17

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Amirreza Faridmoayer ,  Rainer Follador ,  Stefan Jochen Kemmler ,  Michael Thomas Kowarik ,  Gerd Martin Lipowsky ,  Gerald Johann Posch ,  Fabio Serventi

IPC: A61K39/09 ,  C12P19/04 ,  C12P21/00

CPC classification number: A61K39/092 ,  C12P19/04 ,  C12P21/005

Abstract: The disclosure provides synthetic (e.g. recombinant) pneumococcal saccharide comprising one or more repeat unit(s) →4)-β-D-Glcp-(1→3)-[[α-L-Rhap-(1→2)]-[Gro-(2→P→3)]-β-D-Galp-(1→4)]-β-L-Rhap-(1→. Also provided are conjugates comprising a →4)-β-D-Glcp-(1→3)-[[α-L-Rhap-(1→2)]-[Gro-(2→P→3)]-β-D-Galp-(1→4)]-β-L-Rhap-(1→, immunogenic compositions, vaccines and their use in preventing or treating infection by Streptococcus pneumoniae.

公开(公告)号：US11376314B2

公开(公告)日：2022-07-05

申请号：US16620921

申请日：2018-07-17

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Amirreza Faridmoayer ,  Rainer Follador ,  Stefan Jochen Kemmler ,  Michael Thomas Kowarik ,  Gerald Johann Posch ,  Fabio Serventi

IPC: A61K39/09 ,  C08B37/00 ,  A61K39/102 ,  A61K38/00 ,  C07K14/315 ,  A61K35/74 ,  A61K47/36 ,  C07K9/00 ,  B01J20/32

Abstract: The disclosure provides synthetic (e.g. recombinant) pneumococcal saccharides comprising one or more repeat unit(s) →4)-β-D-Glcp-(1→4)-[Gro-(2→P→3)]-β-D-Galp-(1→4)-β-L-Rhap-(1→. Also provided are conjugates comprising a →4)-β-D-Glcp-(1→4)-[Gro-(2→P→3)]-β-D-Galp-(1→4)-β-L-Rhap-(1→, immunogenic compositions, vaccines and their use in preventing or treating infection by Streptococcus pneumoniae.