公开(公告)号：US20150110824A1

公开(公告)日：2015-04-23

申请号：US14385813

申请日：2013-03-18

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： Brigitte Desiree Alberte Colau ,  Sandra Giannini ,  Laurence Lockman

IPC: A61K39/39 ,  C12N7/00 ,  A61K39/12

CPC classification number: A61K39/39 ,  A61K39/12 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/55572 ,  C12N7/00 ,  C12N2710/20023 ,  C12N2710/20034 ,  C12N2710/20071

Abstract: The disclosure provides immunogenic compositions comprising HPV VLPs from one or more HPV types in combination with an adjuvant comprising a TLR agonist for use in a method for the prevention of HPV infection or disease in an individual, wherein a first dose of the immunogenic composition comprising HPV VLPs and a TLR agonist, is administered followed by a second dose of an immunogenic composition comprising HPV VLPs from one or more HPV types but which does not comprise a TLR agonist.

Abstract translation: 本公开提供了包含来自一种或多种HPV类型的HPV VLP与包含用于预防个体的HPV感染或疾病的方法的TLR激动剂的佐剂的免疫原性组合物，其中包含HPV的免疫原性组合物的第一剂量 VLP和TLR激动剂，然后施用第二剂量的包含来自一种或多种HPV类型但不包含TLR激动剂的HPV VLP的免疫原性组合物。

公开(公告)号：US20240299474A1

公开(公告)日：2024-09-12

申请号：US18649491

申请日：2024-04-29

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Christiane Marie-Paule Simone Jeanne Feron ,  Sandra Giannini

IPC: A61K35/76 ,  A61K39/00 ,  A61K39/02 ,  A61K48/00 ,  A61P31/04 ,  C12N9/24 ,  C12N15/85 ,  C12N15/86 ,  C40B40/02

CPC classification number: A61K35/76 ,  A61K39/00 ,  A61K39/02 ,  A61K48/0008 ,  A61K48/005 ,  A61P31/04 ,  C12N9/2405 ,  C12N15/85 ,  C12N15/86 ,  C12Y302/01087 ,  A61K2039/5256 ,  C12N2795/00032 ,  C12N2795/00034 ,  C12N2795/00043 ,  C12N2800/24 ,  C12N2830/00 ,  C40B40/02 ,  Y02A50/30

Abstract: The present invention discloses a recombinant bacteriophage comprising a phage genome polynucleotide including a gene encoding a heterologous antigen protein(s) and a killing gene encoding a protein that is capable of killing a host bacterium. Such a recombinant bacteriophage is designed to prime a subject's immune response and to kill the bacterium that it infects such that the “prime and kill” bacteriophage provides two lines of protection against infectious disease.

公开(公告)号：US12076352B2

公开(公告)日：2024-09-03

申请号：US16973471

申请日：2019-06-18

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Christiane Marie-Paule Simone Jeanne Feron ,  Sandra Giannini

IPC: A61K35/76 ,  C12N7/00

CPC classification number: A61K35/76 ,  C12N7/00 ,  C12N2795/00043 ,  C12N2820/55

Abstract: The present invention discloses an engineered bacteriophage capable of binding to a commensal bacterium and inserting its genome polynucleotide into the commensal bacterium, but incapable of producing progeny, incapable of carrying out a lysogenic cycle and incapable of carrying out a lytic cycle within the commensal bacterium, wherein the engineered bacteriophage comprises a genome polynucleotide including at least one gene encoding at least one heterologous antigen(s) under the control of a promoter.

公开(公告)号：US11266733B2

公开(公告)日：2022-03-08

申请号：US16650790

申请日：2018-09-25

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Wivine Burny ,  Cindy Castado ,  Sandra Giannini ,  Julien Thierry Massaux

IPC: C12N15/86 ,  A61K39/00 ,  A61K39/12 ,  A61K39/155 ,  A61K39/385

Abstract: Nucleotide constructs encoding antigenic peptides or polypeptides derived from multiple Human Papilloma Virus (HPV) early proteins, immunogenic compositions comprising such constructs and a pharmaceutically acceptable carrier, and uses thereof.

公开(公告)号：US11998579B2

公开(公告)日：2024-06-04

申请号：US16064017

申请日：2017-01-03

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Christiane Marie-Paule Simone Jeanne Feron ,  Sandra Giannini

IPC: C12Q1/04 ,  A61K35/76 ,  A61K39/00 ,  A61K39/02 ,  A61K48/00 ,  A61P31/04 ,  C12N9/24 ,  C12N15/85 ,  C12N15/86 ,  C40B40/02

CPC classification number: A61K35/76 ,  A61K39/00 ,  A61K39/02 ,  A61K48/0008 ,  A61K48/005 ,  A61P31/04 ,  C12N9/2405 ,  C12N15/85 ,  C12N15/86 ,  C12Y302/01087 ,  A61K2039/5256 ,  C12N2795/00032 ,  C12N2795/00034 ,  C12N2795/00043 ,  C12N2800/24 ,  C12N2830/00 ,  C40B40/02 ,  Y02A50/30

Abstract: The present invention discloses a recombinant bacteriophage comprising a phage genome polynucleotide including a gene encoding a heterologous antigen protein(s) and a killing gene encoding a protein that is capable of killing a host bacterium. Such a recombinant bacteriophage is designed to prime a subject's immune response and to kill the bacterium that it infects such that the “prime and kill” bacteriophage provides two lines of protection against infectious disease.