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公开(公告)号：US10849897B2
公开(公告)日：2020-12-01
申请号：US16489876
申请日：2018-02-27
发明人： Stephen John Atkinson , Emmanuel Hubert Demont , Lee Andrew Harrison , Etienne Levernier , Alexander G. Preston , Jonathan Thomas Seal , Ian David Wall , Robert J. Watson , James Michael Woolven
IPC分类号： A61K31/506 , A61K31/44 , A61K31/4439 , A61K31/444 , A61K31/501 , C07D213/81 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/12
摘要： The present invention is directed to pyridyl derivatives which are bromodomain inhibitors, pharmaceutical compositions comprising the compounds and the use of the compounds or the compositions in the treatment of various diseases or conditions.
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公开(公告)号：US10370356B2
公开(公告)日：2019-08-06
申请号：US15762229
申请日：2016-09-20
发明人： Stephen John Atkinson , Emmanuel Hubert Demont , Lee Andrew Harrison , Thomas George Christopher Hayhow , David House , Matthew J. Lindon , Alexander G. Preston , Jonathan Thomas Seal , Ian David Wall , Robert J. Watson , James Michael Woolven
IPC分类号： C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541
摘要： The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy
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公开(公告)号：US10471050B2
公开(公告)日：2019-11-12
申请号：US15766222
申请日：2016-10-03
发明人： Stephen John Atkinson , Emmanuel Hubert Demont , Lee Andrew Harrison , Thomas George Christopher Hayhow , Matthew J. Lindon , Alexander G. Preston , Jonathan Thomas Seal , Ian David Wall , Robert J. Watson , James Michael Woolven
IPC分类号： C07D401/14 , A61K31/4412 , C07D213/82 , C07D401/12 , A61P37/06 , A61K31/4439
摘要： The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.
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公开(公告)号：US11273146B2
公开(公告)日：2022-03-15
申请号：US16753544
申请日：2018-10-04
发明人： Stephen John Atkinson , Emmanuel Hubert Demont , Lee Andrew Harrison , Simon Christopher Cranko Lucas , Alexander G. Preston , Jonathan Thomas Seal , Ian David Wall , Robert J. Watson , James Michael Woolven
IPC分类号： A61K31/4025 , A61K31/343 , A61K31/351 , A61K31/397 , A61K31/4155 , A61K31/4192 , A61K31/4196 , A61K31/443 , A61K31/4525 , A61K31/501 , A61K31/506 , A61K45/06 , C07D307/79 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/12 , C07D407/14 , C07D413/12 , C07D471/04
摘要： The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.
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公开(公告)号：US10966961B2
公开(公告)日：2021-04-06
申请号：US16489859
申请日：2018-02-27
发明人： Stephen John Atkinson , Emmanuel Hubert Demont , Lee Andrew Harrison , Gemma Michele Liwicki , Simon Christopher Cranko Lucas , Alexander G. Preston , Jonathan Thomas Seal , Ian David Wall , Robert J. Watson
IPC分类号： A61K31/4155 , C07D405/12 , A61K31/415 , C07D231/14 , C07D403/12 , C07D471/04 , A61K31/437 , A61K31/4439 , C07D401/12 , A61K31/422 , C07D413/12 , A61K31/5377 , C07D405/14 , C07D417/12 , A61K31/4192 , A61K31/4184 , A61K31/4245 , A61K31/433
摘要： The present invention is directed to pyrazole derivatives, pharmaceutical compositions comprising the compounds and the use of the compounds or the compositions in the treatment of various diseases.
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公开(公告)号：US11319307B2
公开(公告)日：2022-05-03
申请号：US16753543
申请日：2018-10-04
发明人： Stephen John Atkinson , Emmanuel Hubert Demont , Lee Andrew Harrison , Simon Christopher Cranko Lucas , Alexander G. Preston , Jonathan Thomas Seal , Ian David Wall , Robert J. Watson , James Michael Woolven
IPC分类号： C07D413/12 , C07D307/80 , C07D405/12 , C07D407/12 , A61K45/06
摘要： The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.
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公开(公告)号：US10934272B2
公开(公告)日：2021-03-02
申请号：US16091567
申请日：2017-04-05
发明人： Stephen John Atkinson , Emmanuel Hubert Demont , Lee Andrew Harrison , Etienne Levernier , Alexander G. Preston , Jonathan Thomas Seal , Ian David Wall , Robert J. Watson , James Michael Woolven
IPC分类号： C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12 , C07D471/04 , C07D413/14 , A61K45/06 , A61K31/4427 , A61K31/443 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , C07D213/81 , C07D405/14
摘要： The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.
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公开(公告)号：US10927080B2
公开(公告)日：2021-02-23
申请号：US16535139
申请日：2019-08-08
发明人： Stephen John Atkinson , Helen Elizabeth Aylott , Anthony William James Cooper , Emmanuel Hubert Demont , Lee Andrew Harrison , Thomas George Christopher Hayhow , Matthew J. Lindon , Alexander G. Preston , Jonathan Thomas Seal , Ian David Wall , Robert J. Watson , James Michael Woolven
IPC分类号： C07D213/82 , A61K31/44 , C07D401/06 , C07D405/06 , C07D413/06 , C07D471/04
摘要： The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy
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![Benzo[b]furans as bromodomain inhibitors](/abs-image/US/2020/03/10/US10583112B2/abs.jpg.150x150.jpg)
公开(公告)号：US10583112B2
公开(公告)日：2020-03-10
申请号：US16091577
申请日：2017-04-05
发明人： Stephen John Atkinson , Emmanuel Hubert Demont , Lee Andrew Harrison , Alexander G. Preston , Jonathan Thomas Seal , Ian David Wall , Robert J. Watson , James Michael Woolven
摘要： The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.
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公开(公告)号：US10428026B2
公开(公告)日：2019-10-01
申请号：US15757199
申请日：2016-08-31
发明人： Stephen John Atkinson , Helen Elizabeth Aylott , Anthony William James Cooper , Emmanuel Hubert Demont , Lee Andrew Harrison , Thomas George Christopher Hayhow , Matthew J. Lindon , Alexander G. Preston , Jonathan Thomas Seal , Ian David Wall , Robert J. Watson , James Michael Woolven
IPC分类号： C07D213/82 , C07D401/06 , C07D405/06 , C07D413/06 , C07D471/04
摘要： The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy
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