专利检索 ap:("GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED") AND inv:"Stephen John Atkinson" 第 1 页

1.

发明授权
2,3-disubstituted 1-acyl-4-amino-1,2,3,4-tetrahydroquinoline derivatives and their use as bromodomain inhibitors 有权

公开(公告)号：US11478478B2

公开(公告)日：2022-10-25

申请号：US16735956

申请日：2020-01-07

申请人： GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

发明人： Dominique Amans , Stephen John Atkinson , Lee Andrew Harrison , David Jonathan Hirst , Robert Peter Law , Matthew Lindon , Alexander Preston , Jonathan Thomas Seal , Christopher Roland Wellaway

IPC分类号： A61K31/506 , C07D401/14 , C07D405/14 , C07D413/14 , C07D215/227 , C07D215/46 , C07D215/48 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/08 , C07D487/08 , C07D498/04 , A61P29/00 , A61P37/00 , A61P31/12 , A61P35/00 , C07D215/44 , A61K31/4375 , A61K31/4706 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/5386 , C07D498/08

摘要： The present invention relates to novel compounds, pharmaceutical compositions containing such compounds and to their use in therapy.

2.

发明授权
Pyridyl derivatives as bromodomain inhibitors 有权

公开(公告)号：US10849897B2

公开(公告)日：2020-12-01

申请号：US16489876

申请日：2018-02-27

申请人： GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

发明人： Stephen John Atkinson , Emmanuel Hubert Demont , Lee Andrew Harrison , Etienne Levernier , Alexander G. Preston , Jonathan Thomas Seal , Ian David Wall , Robert J. Watson , James Michael Woolven

IPC分类号： A61K31/506 , A61K31/44 , A61K31/4439 , A61K31/444 , A61K31/501 , C07D213/81 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/12

摘要： The present invention is directed to pyridyl derivatives which are bromodomain inhibitors, pharmaceutical compositions comprising the compounds and the use of the compounds or the compositions in the treatment of various diseases or conditions.

3.

发明申请
2,3-DISUBSTITUTED 1-ACYL-4-AMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS BROMODOMAIN INHIBITORS 有权

公开(公告)号：US20210046073A1

公开(公告)日：2021-02-18

申请号：US16735956

申请日：2020-01-07

申请人： GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

发明人： Dominique Amans , Stephen John Atkinson , Lee Andrew Harrison , David Jonathan Hirst , Robert Peter Law , Matthew Lindon , Alexander Preston , Jonathan Thomas Seal , Christopher Roland Wellaway

IPC分类号： A61K31/506 , A61P35/00 , A61P31/12 , A61P37/00 , A61P29/00 , C07D498/08 , A61K31/5386 , A61K31/5377 , A61K31/497 , A61K31/496 , A61K31/4709 , A61K31/4706 , A61K31/4375 , C07D215/44 , C07D498/04 , C07D487/08 , C07D471/08 , C07D471/04 , C07D417/14 , C07D417/12 , C07D413/12 , C07D413/04 , C07D409/14 , C07D409/12 , C07D405/04 , C07D401/12 , C07D401/04 , C07D215/48 , C07D215/46 , C07D215/227 , C07D413/14 , C07D405/14 , C07D401/14

摘要： The present invention relates to novel compounds, pharmaceutical compositions containing such compounds and to their use in therapy.

4.

发明授权
2-OXO-1,2-dihydropyridine-3,5-dicarboxamide compounds as bromodomain inhibitors 有权

公开(公告)号：US10471050B2

公开(公告)日：2019-11-12

申请号：US15766222

申请日：2016-10-03

申请人： GlaxoSmithKline Intellectual Property (No. 2) Limited

发明人： Stephen John Atkinson , Emmanuel Hubert Demont , Lee Andrew Harrison , Thomas George Christopher Hayhow , Matthew J. Lindon , Alexander G. Preston , Jonathan Thomas Seal , Ian David Wall , Robert J. Watson , James Michael Woolven

IPC分类号： C07D401/14 , A61K31/4412 , C07D213/82 , C07D401/12 , A61P37/06 , A61K31/4439

摘要： The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.

5.

发明申请
2,3-DISUBSTITUTED 1-ACYL-4-AMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS BROMODOMAIN INHIBITORS 有权

公开(公告)号：US20230040299A1

公开(公告)日：2023-02-09

申请号：US17895273

申请日：2022-08-25

申请人： GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

发明人： Dominique Amans , Stephen John Atkinson , Lee Andrew Harrison , David Jonathan Hirst , Robert Peter Law , Matthew Lindon , Alexander Preston , Jonathan Thomas Seal , Christopher Roland Wellaway

IPC分类号： A61K31/506 , C07D401/14 , C07D405/14 , C07D413/14 , C07D215/227 , C07D215/46 , C07D215/48 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/08 , C07D487/08 , C07D498/04 , A61P29/00 , A61P37/00 , A61P31/12 , A61P35/00 , C07D215/44 , A61K31/4375 , A61K31/4706 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/5386 , C07D498/08

摘要： The present invention relates to novel compounds, pharmaceutical compositions containing such compounds and to their use in therapy.

6.

发明授权
Benzofuran derivatives and their use as bromodomain inhibitors 有权

公开(公告)号：US11273146B2

公开(公告)日：2022-03-15

申请号：US16753544

申请日：2018-10-04

申请人： GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED

发明人： Stephen John Atkinson , Emmanuel Hubert Demont , Lee Andrew Harrison , Simon Christopher Cranko Lucas , Alexander G. Preston , Jonathan Thomas Seal , Ian David Wall , Robert J. Watson , James Michael Woolven

IPC分类号： A61K31/4025 , A61K31/343 , A61K31/351 , A61K31/397 , A61K31/4155 , A61K31/4192 , A61K31/4196 , A61K31/443 , A61K31/4525 , A61K31/501 , A61K31/506 , A61K45/06 , C07D307/79 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/12 , C07D407/14 , C07D413/12 , C07D471/04

摘要： The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.

7.

发明授权
Pyrazole derivatives as bromodomain inhibitors 有权

公开(公告)号：US10966961B2

公开(公告)日：2021-04-06

申请号：US16489859

申请日：2018-02-27

申请人： GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

发明人： Stephen John Atkinson , Emmanuel Hubert Demont , Lee Andrew Harrison , Gemma Michele Liwicki , Simon Christopher Cranko Lucas , Alexander G. Preston , Jonathan Thomas Seal , Ian David Wall , Robert J. Watson

IPC分类号： A61K31/4155 , C07D405/12 , A61K31/415 , C07D231/14 , C07D403/12 , C07D471/04 , A61K31/437 , A61K31/4439 , C07D401/12 , A61K31/422 , C07D413/12 , A61K31/5377 , C07D405/14 , C07D417/12 , A61K31/4192 , A61K31/4184 , A61K31/4245 , A61K31/433

摘要： The present invention is directed to pyrazole derivatives, pharmaceutical compositions comprising the compounds and the use of the compounds or the compositions in the treatment of various diseases.

8.

发明授权
Tetrahydroquinoline derivatives as bromodomain inhibitors 有权

公开(公告)号：US10059699B2

公开(公告)日：2018-08-28

申请号：US15509894

申请日：2015-09-09

申请人： GlaxoSmithKline Intellectual Property (No.2) Limited

发明人： Stephen John Atkinson , David Jonathan Hirst , Philip G. Humphreys , Matthew J. Lindon , Alexander G. Preston , Jonathan Thomas Seal , Christopher Roland Wellaway

IPC分类号： C07D405/14 , C07D401/12

摘要： The present invention relates to specific novel compounds, pharmaceutical compositions containing such compounds and to their use in therapy as bromodomain inhibitors.

9.

发明授权
2,3-disubstituted 1-acyl-4-amino-1,2,3,4-tetrahydroquinoline derivatives and their use as bromodomain inhibitors 有权

公开(公告)号：US10583139B2

公开(公告)日：2020-03-10

申请号：US16016955

申请日：2018-06-25

申请人： GlaxoSmithKline Intellectual Property (No.2) Limited

发明人： Dominique Amans , Stephen John Atkinson , Lee Andrew Harrison , David Jonathan Hirst , Robert Peter Law , Matthew Lindon , Alexander Preston , Jonathan Thomas Seal , Christopher Roland Wellaway

IPC分类号： A61K31/506 , A61K31/497 , C07D401/14 , A61K31/4709 , A61K31/496 , C07D498/08 , A61K31/5377 , A61K31/5386 , A61K31/4375 , A61K31/4706 , C07D498/04 , C07D487/08 , C07D471/08 , C07D471/04 , C07D471/14 , C07D471/12 , C07D413/12 , C07D405/14 , C07D413/14 , C07D215/227 , C07D215/46 , C07D215/48 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D417/12 , C07D417/14 , C07D215/44

摘要： The present invention relates to novel compounds, pharmaceutical compositions containing such compounds and to their use in therapy.

10.

发明授权
Pyridinone dicarboxamide for use as bromodomain inhibitors 有权

公开(公告)号：US10370356B2

公开(公告)日：2019-08-06

申请号：US15762229

申请日：2016-09-20

申请人： GlaxoSmithKline Intellectual Property (No. 2) Limited

发明人： Stephen John Atkinson , Emmanuel Hubert Demont , Lee Andrew Harrison , Thomas George Christopher Hayhow , David House , Matthew J. Lindon , Alexander G. Preston , Jonathan Thomas Seal , Ian David Wall , Robert J. Watson , James Michael Woolven

IPC分类号： C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541

摘要： The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy