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Patent Agency Ranking
公开(公告)号：US20220112174A1
公开(公告)日：2022-04-14
申请号：US17492978
申请日：2021-10-04
Inventor： Edward BRNARDIC , Michael BURY , Rodolfo CADILLA , Jon COLLINS , Yu GUO , Anthony HANDLON , Huijie LI , Yue LI , Daniel PAONE , Christie SCHULTE , Barry SHEARER , Guosen YE , Maben YING , Huichang ZHANG
IPC: C07D401/14
Abstract: This invention relates to novel compounds according to Formula (I) which are antagonists of MrgX2, to pharmaceutical compositions containing them, and to their use in therapy for the treatment of MrgX2-mediated diseases and disorders.
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公开(公告)号：US20210238172A1
公开(公告)日：2021-08-05
申请号：US16652780
申请日：2018-10-04
Inventor： Adam Kenneth CHARNLEY , Michael Gerard DARCY , Jason W. DODSON , Xiaoyang DONG , David FAVRE , Terry Vincent HUGHES , Jianxing KANG , Lara Kathryn LEISTER , Yuehu LI , Yiqian LIAN , John F. MEHLMANN , Neysa NEVINS , Joshi M. RAMANJULU , Joseph J. ROMANO , Gren Z. WANG , Guosen YE , Daohua ZHANG
IPC: C07D413/14
Abstract: The invention relates to combinations comprising a compound of the formula: or a salt thereof; and one or more additional pharmaceutically agents active against HIV, and methods of using the same.
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公开(公告)号：US20230071675A1
公开(公告)日：2023-03-09
申请号：US17663749
申请日：2022-05-17
Inventor： Adam Kenneth CHARNLEY , Michael G DARCY , Jason W. DODSON , Xiaoyang DONG , Terry V. HUGHES , Jianxing KANG , Lara LEISTER , Yiqian LIAN , Yue LI , John F. MEHLMANN , Neysa NEVINS , Joshi M. RAMANJULU , Joseph J. ROMANO , Gren Z. WANG , Guosen YE , Daohua ZHANG
IPC: C07D403/14 , C07D405/14 , C07D413/14 , C07D487/22 , C07D493/10 , C07D498/18 , C07F9/6558
Abstract: Disclosed are compounds having the formula: wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.
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公开(公告)号：US20250136722A1
公开(公告)日：2025-05-01
申请号：US18682193
申请日：2022-08-12
Inventor： Peiling CHEN , Michael Gerard DARCY , Jason W. DODSON , Beth A. KNAPP-REED , Craig LEACH , Yuehu LI , Andrew Peter MARCUS , Joseph Paul MARINO , Jeffrey Alan OPLINGER , James P. PHELAN , Matthew Robert SENDER , Brandon TURUNEN , Guosen YE , Cunyu ZHANG , Jae U. JEONG
Abstract: The present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an exogenous antibody protein. The present disclosure also relates to agents capable of binding to a receptor on a surface of a pathogenic cell and inducing the depletion of the pathogenic cell in a subject for use in the treatment of cancer, inflammatory diseases, autoimmune diseases, viral infection, or bacterial infection.
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公开(公告)号：US20240325392A1
公开(公告)日：2024-10-03
申请号：US18437813
申请日：2024-02-09
Inventor： Peiling CHEN , Jason W. DODSON , Beth A. KNAPP-REED , Craig LEACH , Yuehu LI , Joseph Paul MARINO, JR. , Matthew Robert SENDER , Brandon TURUNEN , Guosen YE , Cunyu ZHANG
IPC: A61K31/517 , A61K39/00 , A61P35/00 , C07D401/14 , C07K16/16
CPC classification number: A61K31/517 , A61P35/00 , C07D401/14 , C07K16/16 , A61K2039/505 , C07K2317/565
Abstract: The present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an exogenous antibody protein. The present disclosure also relates to agents capable of binding to a receptor on a surface of a pathogenic cell and inducing the depletion of the pathogenic cell in a subject for use in the treatment of cancer, inflammatory diseases, autoimmune diseases, viral infection, or bacterial infection.
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