公开(公告)号：US20230071675A1

公开(公告)日：2023-03-09

申请号：US17663749

申请日：2022-05-17

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Adam Kenneth CHARNLEY ,  Michael G DARCY ,  Jason W. DODSON ,  Xiaoyang DONG ,  Terry V. HUGHES ,  Jianxing KANG ,  Lara LEISTER ,  Yiqian LIAN ,  Yue LI ,  John F. MEHLMANN ,  Neysa NEVINS ,  Joshi M. RAMANJULU ,  Joseph J. ROMANO ,  Gren Z. WANG ,  Guosen YE ,  Daohua ZHANG

IPC: C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/22 ,  C07D493/10 ,  C07D498/18 ,  C07F9/6558

Abstract: Disclosed are compounds having the formula: wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.

公开(公告)号：US20170158724A1

公开(公告)日：2017-06-08

申请号：US15368921

申请日：2016-12-05

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Jerry ADAMS ,  Kevin J. DUFFY ,  Yiqian LIAN

IPC: C07F9/6574 ,  A61K39/39

CPC classification number: C07H21/04 ,  A61K31/7084 ,  A61K39/39 ,  A61K2039/55511 ,  C07F9/65746 ,  C07H21/00 ,  C07H21/02

Abstract: A compound of Formula (I) wherein Y1, Y2, X1, X2, R1, R2, R3, R4, R5, R6, R8, and R9 are as defined herein; and pharmaceutically acceptable salts and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer, pre-cancerous syndromes and as vaccine adjuvants.

公开(公告)号：US20180258132A1

公开(公告)日：2018-09-13

申请号：US15979729

申请日：2018-05-15

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Jerry ADAMS ,  Yiqian LIAN

IPC: C07H21/04 ,  C07H21/02 ,  C07F9/6574 ,  A61K31/7084 ,  A61K39/39 ,  A61K39/00

CPC classification number: C07H21/04 ,  A61K31/7084 ,  A61K39/39 ,  A61K2039/55511 ,  C07F9/65746 ,  C07H21/00 ,  C07H21/02

Abstract: A compound of Formula (I) wherein Y1, Y2, X1, X2, R1, R2, R3, R4, R5, R6, R8, and R9 are as defined herein; and pharmaceutically acceptable salts and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer, pre-cancerous syndromes and as vaccine adjuvants.

公开(公告)号：US20210238172A1

公开(公告)日：2021-08-05

申请号：US16652780

申请日：2018-10-04

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Adam Kenneth CHARNLEY ,  Michael Gerard DARCY ,  Jason W. DODSON ,  Xiaoyang DONG ,  David FAVRE ,  Terry Vincent HUGHES ,  Jianxing KANG ,  Lara Kathryn LEISTER ,  Yuehu LI ,  Yiqian LIAN ,  John F. MEHLMANN ,  Neysa NEVINS ,  Joshi M. RAMANJULU ,  Joseph J. ROMANO ,  Gren Z. WANG ,  Guosen YE ,  Daohua ZHANG

IPC: C07D413/14

Abstract: The invention relates to combinations comprising a compound of the formula: or a salt thereof; and one or more additional pharmaceutically agents active against HIV, and methods of using the same.