公开(公告)号：US20170008878A1

公开(公告)日：2017-01-12

申请号：US15271581

申请日：2016-09-21

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Deepak BANDYOPADHYAY ,  Patrick M. EIDAM ,  Peter J. GOUGH ,  Philip Anthony HARRIS ,  Jae U. JEONG ,  Jianxing KANG ,  Bryan Wayne KING ,  Ami LAKDAWALA SHAH ,  Lara Kathryn LEISTER ,  Robert W. MARQUIS, JR. ,  Attiq RAHMAN ,  Joshi M. RAMANJULU ,  Clark A. SEHON ,  Robert SINGHAUS, JR. ,  Daohua ZHANG

IPC: C07D403/12

CPC classification number: A61K31/553 ,  A61K31/55 ,  C07D223/08 ,  C07D267/14 ,  C07D281/10 ,  C07D403/12 ,  C07D403/14 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D487/04 ,  C07D498/04

Abstract: Disclosed are compounds having the formula: wherein X, Y, Z1, Z2, Z3, Z4, R5, RA, m, A. L, and B are as defined herein, and methods of making and using the same.

Abstract translation: 其中X，Y，Z 1，Z 2，Z 3，Z 4，R 5，RA，m，A L和B如本文所定义，以及制备和使用它们的方法。

公开(公告)号：US20150353533A1

公开(公告)日：2015-12-10

申请号：US14763183

申请日：2014-02-14

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Deepak BANDYOPADHYAY ,  Patrick M. EIDAM ,  Peter J. GOUGH ,  Philip Anthony HARRIS ,  Jae U. JEONG ,  Jianxing KANG ,  Bryan Wayne KING ,  Ami LAKDAWALA SHAH ,  Lara Kathryn LEISTER ,  Robert W. MARQUIS, JR. ,  Attiq RAHMAN ,  Joshi M. RAMANJULU ,  Clark A. SEHON ,  Robert SINGHAUS, JR. ,  Daohua ZHANG

IPC: C07D413/12 ,  C07D403/12

CPC classification number: A61K31/553 ,  A61K31/55 ,  C07D223/08 ,  C07D267/14 ,  C07D281/10 ,  C07D403/12 ,  C07D403/14 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D487/04 ,  C07D498/04

Abstract: Disclosed are compounds having the formula: wherein X, Y, Z1, Z2, Z3, Z4, R5, RA, m, A, L, and B are as defined herein, and methods of making and using the same.

Abstract translation: 公开了具有下式的化合物：其中X，Y，Z1，Z2，Z3，Z4，R5，RA，m，A，L和B如本文所定义，以及制备和使用它们的方法。

公开(公告)号：US20210238172A1

公开(公告)日：2021-08-05

申请号：US16652780

申请日：2018-10-04

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Adam Kenneth CHARNLEY ,  Michael Gerard DARCY ,  Jason W. DODSON ,  Xiaoyang DONG ,  David FAVRE ,  Terry Vincent HUGHES ,  Jianxing KANG ,  Lara Kathryn LEISTER ,  Yuehu LI ,  Yiqian LIAN ,  John F. MEHLMANN ,  Neysa NEVINS ,  Joshi M. RAMANJULU ,  Joseph J. ROMANO ,  Gren Z. WANG ,  Guosen YE ,  Daohua ZHANG

IPC: C07D413/14

Abstract: The invention relates to combinations comprising a compound of the formula: or a salt thereof; and one or more additional pharmaceutically agents active against HIV, and methods of using the same.

公开(公告)号：US20180022737A1

公开(公告)日：2018-01-25

申请号：US15548500

申请日：2016-02-12

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Ann Marie DIEDERICH ,  Philip Anthony HARRIS ,  Robert HERRMANN ,  John KENNA ,  Lara Kathryn LEISTER

IPC: C07D413/12 ,  A61K31/553 ,  C07C223/04 ,  C07D267/14 ,  C07D249/10

CPC classification number: C07D413/12 ,  A61K31/553 ,  A61K2300/00 ,  C07C223/04 ,  C07D249/10 ,  C07D267/14

Abstract: Disclosed are novel crystalline forms of (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide, and solvates thereof and pharmaceutical compositions containing the same. Also disclosed are processes for the preparation thereof and methods for use thereof.