公开(公告)号：US20230071675A1

公开(公告)日：2023-03-09

申请号：US17663749

申请日：2022-05-17

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Adam Kenneth CHARNLEY ,  Michael G DARCY ,  Jason W. DODSON ,  Xiaoyang DONG ,  Terry V. HUGHES ,  Jianxing KANG ,  Lara LEISTER ,  Yiqian LIAN ,  Yue LI ,  John F. MEHLMANN ,  Neysa NEVINS ,  Joshi M. RAMANJULU ,  Joseph J. ROMANO ,  Gren Z. WANG ,  Guosen YE ,  Daohua ZHANG

IPC: C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/22 ,  C07D493/10 ,  C07D498/18 ,  C07F9/6558

Abstract: Disclosed are compounds having the formula: wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.

公开(公告)号：US20210238172A1

公开(公告)日：2021-08-05

申请号：US16652780

申请日：2018-10-04

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Adam Kenneth CHARNLEY ,  Michael Gerard DARCY ,  Jason W. DODSON ,  Xiaoyang DONG ,  David FAVRE ,  Terry Vincent HUGHES ,  Jianxing KANG ,  Lara Kathryn LEISTER ,  Yuehu LI ,  Yiqian LIAN ,  John F. MEHLMANN ,  Neysa NEVINS ,  Joshi M. RAMANJULU ,  Joseph J. ROMANO ,  Gren Z. WANG ,  Guosen YE ,  Daohua ZHANG

IPC: C07D413/14

Abstract: The invention relates to combinations comprising a compound of the formula: or a salt thereof; and one or more additional pharmaceutically agents active against HIV, and methods of using the same.

公开(公告)号：US20250136722A1

公开(公告)日：2025-05-01

申请号：US18682193

申请日：2022-08-12

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Peiling CHEN ,  Michael Gerard DARCY ,  Jason W. DODSON ,  Beth A. KNAPP-REED ,  Craig LEACH ,  Yuehu LI ,  Andrew Peter MARCUS ,  Joseph Paul MARINO ,  Jeffrey Alan OPLINGER ,  James P. PHELAN ,  Matthew Robert SENDER ,  Brandon TURUNEN ,  Guosen YE ,  Cunyu ZHANG ,  Jae U. JEONG

IPC: C07K16/44 ,  A61K39/00 ,  A61K47/55 ,  A61P35/00

Abstract: The present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an exogenous antibody protein. The present disclosure also relates to agents capable of binding to a receptor on a surface of a pathogenic cell and inducing the depletion of the pathogenic cell in a subject for use in the treatment of cancer, inflammatory diseases, autoimmune diseases, viral infection, or bacterial infection.

公开(公告)号：US20240325392A1

公开(公告)日：2024-10-03

申请号：US18437813

申请日：2024-02-09

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Peiling CHEN ,  Jason W. DODSON ,  Beth A. KNAPP-REED ,  Craig LEACH ,  Yuehu LI ,  Joseph Paul MARINO, JR. ,  Matthew Robert SENDER ,  Brandon TURUNEN ,  Guosen YE ,  Cunyu ZHANG

IPC: A61K31/517 ,  A61K39/00 ,  A61P35/00 ,  C07D401/14 ,  C07K16/16

CPC classification number: A61K31/517 ,  A61P35/00 ,  C07D401/14 ,  C07K16/16 ,  A61K2039/505 ,  C07K2317/565

Abstract: The present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an exogenous antibody protein. The present disclosure also relates to agents capable of binding to a receptor on a surface of a pathogenic cell and inducing the depletion of the pathogenic cell in a subject for use in the treatment of cancer, inflammatory diseases, autoimmune diseases, viral infection, or bacterial infection.