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公开(公告)号：US20240083896A1
公开(公告)日：2024-03-14
申请号：US18256982
申请日：2021-12-16
Inventor： Xiaoyang DONG , Mark Andrew ELBAN , Jie GUANG , Ming-Hsun HO , Tram H. HOANG , Joseph J. ROMANO , David Glenn WASHBURN
IPC: C07D471/04 , C07D487/04
CPC classification number: C07D471/04 , C07D487/04
Abstract: Compounds of formula (I) are described, wherein each of the variable groups is as defined in the specification. Also described are pharmaceutical compositions containing a compound of formula (I), and uses of the compounds and pharmaceutical compositions for inhibiting Nav1.8 voltage-gated sodium channels and treating Nav1.8 mediated diseases, disorders, and conditions, such as pain and pain-associated diseases, disorders, and conditions and cardiovascular diseases, disorders, and conditions, such as atrial fibrillation.
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公开(公告)号：US20180085365A1
公开(公告)日：2018-03-29
申请号：US15811712
申请日：2017-11-14
Inventor： Michael Jonathan BURY , Linda N. CASILLAS , Adam Kenneth CHARNLEY , Pamela A. HAILE , Robert W. MARQUIS, JR. , John F. MEHLMANN , Joseph J. ROMANO , Robert R. SINGHAUS, JR. , Gren Z. WANG
IPC: A61K31/4709 , A61K31/4706
CPC classification number: A61K31/4709 , A61K31/4706 , C07D215/44 , C07D401/12 , C07D405/12 , C07D405/14 , C07D417/12 , C07D417/14 , C07D471/04
Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3 and Z are as defined herein, and methods of making and using the same.
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公开(公告)号：US20230071675A1
公开(公告)日：2023-03-09
申请号：US17663749
申请日：2022-05-17
Inventor： Adam Kenneth CHARNLEY , Michael G DARCY , Jason W. DODSON , Xiaoyang DONG , Terry V. HUGHES , Jianxing KANG , Lara LEISTER , Yiqian LIAN , Yue LI , John F. MEHLMANN , Neysa NEVINS , Joshi M. RAMANJULU , Joseph J. ROMANO , Gren Z. WANG , Guosen YE , Daohua ZHANG
IPC: C07D403/14 , C07D405/14 , C07D413/14 , C07D487/22 , C07D493/10 , C07D498/18 , C07F9/6558
Abstract: Disclosed are compounds having the formula: wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.
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Patent Agency Ranking
公开(公告)号：US20180105514A1
公开(公告)日：2018-04-19
申请号：US15730664
申请日：2018-01-03
Inventor： John F. MEHLMANN , Joseph J. ROMANO
IPC: C07D403/14
CPC classification number: C07D403/14 , C07D405/14 , C07D413/14 , C07D487/22 , C07D493/10 , C07D498/18 , C07F9/65583
Abstract: Disclosed are compounds having the formula: wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.
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公开(公告)号：US20210238172A1
公开(公告)日：2021-08-05
申请号：US16652780
申请日：2018-10-04
Inventor： Adam Kenneth CHARNLEY , Michael Gerard DARCY , Jason W. DODSON , Xiaoyang DONG , David FAVRE , Terry Vincent HUGHES , Jianxing KANG , Lara Kathryn LEISTER , Yuehu LI , Yiqian LIAN , John F. MEHLMANN , Neysa NEVINS , Joshi M. RAMANJULU , Joseph J. ROMANO , Gren Z. WANG , Guosen YE , Daohua ZHANG
IPC: C07D413/14
Abstract: The invention relates to combinations comprising a compound of the formula: or a salt thereof; and one or more additional pharmaceutically agents active against HIV, and methods of using the same.
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公开(公告)号：US20170128437A1
公开(公告)日：2017-05-11
申请号：US15413792
申请日：2017-01-24
Inventor： Michael Jonathan BURY , Linda N. CASILLAS , Adam Kenneth CHARNLEY , Pamela A. HAILE , Robert W. MARQUIS, JR. , John F. MEHLMANN , Joseph J. ROMANO , Robert R. SINGHAUS, JR. , Gren Z. WANG
IPC: A61K31/4709 , A61K31/4706
CPC classification number: A61K31/4709 , A61K31/4706 , C07D215/44 , C07D401/12 , C07D405/12 , C07D405/14 , C07D417/12 , C07D417/14 , C07D471/04
Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3 and Z are as defined herein, and methods of making and using the same.
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公开(公告)号：US20170152233A1
公开(公告)日：2017-06-01
申请号：US15431942
申请日：2017-02-14
Inventor： Michael Jonathan BURY , Linda N. CASILLAS , Adam K. CHARNLEY , Michael P. DEMARTINO , Xiaoyang DONG , Patrick M. EIDAM , Pamela A. HAILE , Robert W. MARQUIS, JR. , Joshi M. RAMANJULU , Joseph J. ROMANO , Ami Lakdawala SHAH , Robert R. SINGHAUS, JR. , Gren WANG
IPC: C07D239/94 , C07D403/12 , C07D417/14 , C07D417/12
CPC classification number: C07D239/94 , C07D403/12 , C07D417/12 , C07D417/14 , C07D471/04
Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3, and Z are as defined herein, and methods of making and using the same.
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公开(公告)号：US20160060222A1
公开(公告)日：2016-03-03
申请号：US14934395
申请日：2015-11-06
Inventor： Michael Jonathan BURY , Linda N. CASILLAS , Adam Kenneth CHARNLEY , Michael P. DeMARTINO , Xiaoyang DONG , Patrick EIDAM , Pamela A. HAILE , Philip Anthony HARRIS , Ami Lakdawala SHAH , Bryan W. KING , Robert W. MARQUIS, JR. , John F. MEHLMANN , Joseph J. ROMANO , Clark A. SEHON
IPC: C07D215/42 , C07D215/44 , C07D401/12 , C07D405/12 , C07D411/12 , C07D215/48 , C07D471/04 , C07D417/14 , C07D513/04 , C07D405/14 , C07D401/14 , C07D417/12 , C07D413/12
CPC classification number: C07D215/42 , A61K31/47 , C07D215/44 , C07D215/48 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D411/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
Abstract: Disclosed are quinoline compounds having the formula: wherein R1, R2 and A are as defined herein, and methods of making and using the same.
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