公开(公告)号：US10220030B2

公开(公告)日：2019-03-05

申请号：US15811712

申请日：2017-11-14

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Michael Jonathan Bury ,  Linda N. Casillas ,  Adam Kenneth Charnley ,  Pamela A. Haile ,  Robert W. Marquis, Jr. ,  John F. Mehlmann ,  Joseph J. Romano ,  Robert R. Singhaus, Jr. ,  Gren Z. Wang

IPC: A61K31/4709 ,  C07D401/12 ,  C07D405/14 ,  C07D417/12 ,  C07D215/44 ,  C07D405/12 ,  C07D417/14 ,  C07D471/04 ,  A61K31/4706

Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3 and Z are as defined herein, and methods of making and using the same.

公开(公告)号：US09868724B2

公开(公告)日：2018-01-16

申请号：US15314107

申请日：2015-05-26

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Hui Lei ,  Xin Ma ,  Feng Ren ,  Xichen Lin ,  Robert W. Marquis, Jr.

IPC: C07D417/14 ,  C07D405/14 ,  C07D405/06 ,  C07D241/04

CPC classification number: C07D405/06 ,  C07D241/04 ,  C07D405/14 ,  C07D417/14

Abstract: The present invention relates to novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORγ.

公开(公告)号：US09994529B2

公开(公告)日：2018-06-12

申请号：US15431942

申请日：2017-02-14

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Michael Jonathan Bury ,  Linda N. Casillas ,  Adam K. Charnley ,  Michael P. Demartino ,  Xiaoyang Dong ,  Patrick M. Eidam ,  Pamela A. Haile ,  Robert W. Marquis, Jr. ,  Joshi M. Ramanjulu ,  Joseph J. Romano ,  Ami Lakdawala Shah ,  Robert R. Singhaus, Jr. ,  Gren Wang

IPC: C07D239/94 ,  C07D403/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

CPC classification number: C07D239/94 ,  C07D403/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3, and Z are as defined herein, and methods of making and using the same.

公开(公告)号：US09586953B2

公开(公告)日：2017-03-07

申请号：US14397218

申请日：2013-09-13

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Linda N. Casillas ,  Pamela A. Haile ,  Robert W. Marquis, Jr.

IPC: C07D417/12 ,  A61K31/428 ,  A61K31/517 ,  C07F9/6561

CPC classification number: C07D417/12 ,  A61K31/09 ,  A61K31/198 ,  A61K31/381 ,  A61K31/428 ,  A61K31/433 ,  A61K31/517 ,  C07F9/6561

Abstract: Disclosed are compounds having the formula: wherein X is as defined herein, and methods of making and using the same.

Abstract translation: 公开了具有下式的化合物：其中X如本文所定义，及其制备和使用方法。