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公开(公告)号：US20230047296A1
公开(公告)日：2023-02-16
申请号：US17495115
申请日：2021-10-06
发明人： Jeffrey K. KERNS , James Callahan , Hongxing Yan , Thomas Daniel Heightman , Charlotte Mary Griffiths-Jones , Alison Jo-Anne Woolford , Tindy Li , Ami Lakdawala Shah , Roderick S. Davis , David Norton , Jeffrey Charles Boehm , Paris L. Hamilton , Nicole Cathleen Goodwin , Yun Jin
IPC分类号： C07D403/10 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/10 , C07D403/14 , C07D413/10 , C07D471/04 , C07D487/04 , C07D498/04 , C07D267/14 , C07D249/18 , C07D233/60 , C07D487/08 , C07D451/02 , A61P9/00 , A61P25/00 , A61P11/00 , A61P27/00 , A61P35/00 , A61P37/00 , C07D233/64 , C07D255/04 , C07D273/01 , C07D405/10
摘要： The present invention relates to aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.
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公开(公告)号：US10604509B2
公开(公告)日：2020-03-31
申请号：US15736075
申请日：2016-06-15
发明人： Jeffrey K. Kerns , James Callahan , Thomas Daniel Heightman , Alison Jo-Anne Woolford , Ami Lakdawala Shah , Roderick S. Davis , David Norton , Jeffrey Charles Boehm , Nicole Cathleen Goodwin
IPC分类号： C07D417/10 , C07D403/10 , C07D249/04 , C07D249/18 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/10 , C07D403/14 , C07D413/10 , C07D471/04 , C07D487/04 , C07D498/04 , C07D267/14 , C07D233/60 , C07D487/08 , C07D451/02 , A61P9/00 , A61P25/00 , A61P11/00 , A61P27/00 , A61P35/00 , A61P37/00 , C07D233/64 , C07D255/04 , C07D273/01 , C07D405/10
摘要： Provided are aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.
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公开(公告)号：US20200079759A1
公开(公告)日：2020-03-12
申请号：US16675634
申请日：2019-11-06
发明人： Jeffrey K. KERNS , James Callahan , Hongxing Yan , Thomas Daniel Heightman , Charlotte Mary Griffiths-Jones , Alison Jo-Anne Woolford , Tindy Li , Ami Lakdawala Shah , Roderick S. Davis , David Norton , Jeffrey Charles Boehm , Paris L. Hamilton , Nicole Cathleen Goodwin , Yun Jin
IPC分类号： C07D403/10 , C07D267/14 , C07D249/18 , C07D233/60 , C07D487/08 , C07D451/02 , A61P9/00 , A61P25/00 , A61P11/00 , A61P27/00 , A61P35/00 , A61P37/00 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/10 , C07D403/14 , C07D413/10 , C07D471/04 , C07D487/04 , C07D498/04 , C07D233/64 , C07D255/04 , C07D273/01 , C07D405/10
摘要： The present invention relates to aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.
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公开(公告)号：US11117905B2
公开(公告)日：2021-09-14
申请号：US16467193
申请日：2017-12-11
IPC分类号： A61K8/00 , A61K9/00 , C07D243/08 , C07D281/02 , C07D291/08 , C07D513/04 , C07D515/04 , C07D285/36 , C07D409/14
摘要： The present invention relates to bisaryl heterocycle compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the invention relates to bisaryl heterocycles of Formula (I),
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公开(公告)号：US20160318917A1
公开(公告)日：2016-11-03
申请号：US15105306
申请日：2014-12-17
发明人： Jeffrey Charles Boehm , Thomas Glanmor Davies , Alison Jo-anne Woolford , Charlotte Mary Griffiths-Jones , Hendrika Maria Gerarda Willems , David Norton , Gordon Saxity , Thomas Daniel Heightman , Tindy Li , Jeffrey K. Kerns , Roderick S. Davis , Hongxing Yan
IPC分类号： C07D417/10 , C07D515/04 , C07D401/12 , C07D513/04 , C07D249/18 , C07D291/08 , C07D471/04 , C07D417/14 , C07D403/12 , C07D419/14 , C07D281/02 , C07D419/10 , C07D405/12
CPC分类号： C07D417/10 , C07D249/18 , C07D281/02 , C07D291/08 , C07D401/12 , C07D403/12 , C07D405/12 , C07D417/14 , C07D419/10 , C07D419/14 , C07D471/04 , C07D513/04 , C07D515/04
摘要： The present invention relates to bis aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators.
摘要翻译： 本发明涉及双芳基类似物，含有它们的药物组合物及其作为Nrf2调节剂的用途。
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