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公开(公告)号：US20230047296A1
公开(公告)日：2023-02-16
申请号：US17495115
申请日：2021-10-06
发明人： Jeffrey K. KERNS , James Callahan , Hongxing Yan , Thomas Daniel Heightman , Charlotte Mary Griffiths-Jones , Alison Jo-Anne Woolford , Tindy Li , Ami Lakdawala Shah , Roderick S. Davis , David Norton , Jeffrey Charles Boehm , Paris L. Hamilton , Nicole Cathleen Goodwin , Yun Jin
IPC分类号： C07D403/10 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/10 , C07D403/14 , C07D413/10 , C07D471/04 , C07D487/04 , C07D498/04 , C07D267/14 , C07D249/18 , C07D233/60 , C07D487/08 , C07D451/02 , A61P9/00 , A61P25/00 , A61P11/00 , A61P27/00 , A61P35/00 , A61P37/00 , C07D233/64 , C07D255/04 , C07D273/01 , C07D405/10
摘要： The present invention relates to aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.
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公开(公告)号：US10604509B2
公开(公告)日：2020-03-31
申请号：US15736075
申请日：2016-06-15
发明人： Jeffrey K. Kerns , James Callahan , Thomas Daniel Heightman , Alison Jo-Anne Woolford , Ami Lakdawala Shah , Roderick S. Davis , David Norton , Jeffrey Charles Boehm , Nicole Cathleen Goodwin
IPC分类号： C07D417/10 , C07D403/10 , C07D249/04 , C07D249/18 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/10 , C07D403/14 , C07D413/10 , C07D471/04 , C07D487/04 , C07D498/04 , C07D267/14 , C07D233/60 , C07D487/08 , C07D451/02 , A61P9/00 , A61P25/00 , A61P11/00 , A61P27/00 , A61P35/00 , A61P37/00 , C07D233/64 , C07D255/04 , C07D273/01 , C07D405/10
摘要： Provided are aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.
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公开(公告)号：US20200079759A1
公开(公告)日：2020-03-12
申请号：US16675634
申请日：2019-11-06
发明人： Jeffrey K. KERNS , James Callahan , Hongxing Yan , Thomas Daniel Heightman , Charlotte Mary Griffiths-Jones , Alison Jo-Anne Woolford , Tindy Li , Ami Lakdawala Shah , Roderick S. Davis , David Norton , Jeffrey Charles Boehm , Paris L. Hamilton , Nicole Cathleen Goodwin , Yun Jin
IPC分类号： C07D403/10 , C07D267/14 , C07D249/18 , C07D233/60 , C07D487/08 , C07D451/02 , A61P9/00 , A61P25/00 , A61P11/00 , A61P27/00 , A61P35/00 , A61P37/00 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/10 , C07D403/14 , C07D413/10 , C07D471/04 , C07D487/04 , C07D498/04 , C07D233/64 , C07D255/04 , C07D273/01 , C07D405/10
摘要： The present invention relates to aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.
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公开(公告)号：US20190262356A1
公开(公告)日：2019-08-29
申请号：US16408718
申请日：2019-05-10
发明人： Jae U. JEONG , Deepak Bandyopadhyay , Patrick M. Eidam , Philip Anthony Harris , Jianxing Kang , Bryan Wayne King , Ami Lakdawala Shah , Lara Kathryn Leister , Attiq Rahman , Joshi M. Ramanjulu , Clark A. Sehon , Robert Singhaus, JR. , Daohua Zhang
IPC分类号： A61K31/553 , C07D413/14 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/12 , A61K31/55 , C07D267/14 , C07D498/04 , C07D281/10 , C07D223/08 , C07D403/12 , C07D487/04
摘要： Disclosed are compounds having the formula: wherein X, Y, Z1, Z2, Z3, Z4, R5, RA, m, A. L, and B are as defined herein, and methods of making and using the same.
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公开(公告)号：US09994529B2
公开(公告)日：2018-06-12
申请号：US15431942
申请日：2017-02-14
发明人： Michael Jonathan Bury , Linda N. Casillas , Adam K. Charnley , Michael P. Demartino , Xiaoyang Dong , Patrick M. Eidam , Pamela A. Haile , Robert W. Marquis, Jr. , Joshi M. Ramanjulu , Joseph J. Romano , Ami Lakdawala Shah , Robert R. Singhaus, Jr. , Gren Wang
IPC分类号： C07D239/94 , C07D403/12 , C07D417/12 , C07D417/14 , C07D471/04
CPC分类号： C07D239/94 , C07D403/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Disclosed are compounds having the formula: wherein R1, R2, R3, and Z are as defined herein, and methods of making and using the same.
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公开(公告)号：US10292987B2
公开(公告)日：2019-05-21
申请号：US15459141
申请日：2017-03-15
发明人： Jae U. Jeong , Deepak Bandyopadhyay , Patrick M. Eidam , Philip Anthony Harris , Jianxing Kang , Bryan Wayne King , Ami Lakdawala Shah , Lara Kathryn Leister , Attiq Rahman , Joshi M. Ramanjulu , Clark A. Sehon , Robert Singhaus, Jr. , Daohua Zhang
IPC分类号： A61K31/553 , C07D267/14 , C07D403/12 , C07D413/14 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D487/04 , C07D498/04 , C07D281/10 , A61K31/55 , C07D223/08
摘要： Disclosed are compounds having the formula: wherein X, Y, Z1, Z2, Z3, Z4, R5, RA, m, A. L, and B are as defined herein, and methods of making and using the same.
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公开(公告)号：US20190201413A1
公开(公告)日：2019-07-04
申请号：US16299254
申请日：2019-03-12
发明人： Jae U. JEONG , Deepak Bandyopadhyay , Patrick M. Eidam , Philip Anthony Harris , Jianxing Kang , Bryan Wayne King , Ami Lakdawala Shah , Lara Kathryn Leister , Attiq Rahman , Joshi M. Ramanjulu , Clark A. Sehon , Robert Singhaus, JR. , Daohua Zhang
IPC分类号： A61K31/553 , A61K31/55 , C07D403/12 , C07D223/08 , C07D281/10 , C07D498/04 , C07D413/14 , C07D487/04 , C07D417/12 , C07D413/12 , C07D409/12 , C07D403/14 , C07D267/14
CPC分类号： A61K31/553 , A61K31/55 , C07D223/08 , C07D267/14 , C07D281/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D487/04 , C07D498/04
摘要： Disclosed are compounds having the formula: wherein X, Y, Z1, Z2, Z3, Z4, R5, RA, m, A. L, and B are as defined herein, and methods of making and using the same.
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公开(公告)号：US10940154B2
公开(公告)日：2021-03-09
申请号：US16408718
申请日：2019-05-10
发明人： Jae U. Jeong , Deepak Bandyopadhyay , Patrick M. Eidam , Philip Anthony Harris , Jianxing Kang , Bryan Wayne King , Ami Lakdawala Shah , Lara Kathryn Leister , Attiq Rahman , Joshi M. Ramanjulu , Clark A. Sehon , Robert Singhaus, Jr. , Daohua Zhang
IPC分类号： A61K31/553 , A61K31/55 , C07D413/14 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D487/04 , C07D267/14 , C07D498/04 , C07D281/10 , A61K31/551 , C07D403/12 , C07D223/08
摘要： Disclosed are compounds having the formula: wherein X, Y, Z1, Z2, Z3, Z4, R5, RA, m, A. L, and B are as defined herein, and methods of making and using the same.
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公开(公告)号：US10933070B2
公开(公告)日：2021-03-02
申请号：US16299254
申请日：2019-03-12
发明人： Jae U. Jeong , Deepak Bandyopadhyay , Patrick M. Eidam , Philip Anthony Harris , Jianxing Kang , Bryan Wayne King , Ami Lakdawala Shah , Lara Kathryn Leister , Attiq Rahman , Joshi M. Ramanjulu , Clark A. Sehon , Robert Singhaus, Jr. , Daohua Zhang
IPC分类号： A61K31/55 , A61K31/551 , A61K31/553 , C07D413/14 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D487/04 , C07D267/14 , C07D498/04 , C07D281/10 , C07D403/12 , C07D223/08
摘要： Disclosed are compounds having the formula: wherein X, Y, Z1, Z2, Z3, Z4, R5, RA, m, A. L, and B are as defined herein, and methods of making and using the same.
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