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公开(公告)号：US20230047296A1
公开(公告)日：2023-02-16
申请号：US17495115
申请日：2021-10-06
发明人： Jeffrey K. KERNS , James Callahan , Hongxing Yan , Thomas Daniel Heightman , Charlotte Mary Griffiths-Jones , Alison Jo-Anne Woolford , Tindy Li , Ami Lakdawala Shah , Roderick S. Davis , David Norton , Jeffrey Charles Boehm , Paris L. Hamilton , Nicole Cathleen Goodwin , Yun Jin
IPC分类号： C07D403/10 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/10 , C07D403/14 , C07D413/10 , C07D471/04 , C07D487/04 , C07D498/04 , C07D267/14 , C07D249/18 , C07D233/60 , C07D487/08 , C07D451/02 , A61P9/00 , A61P25/00 , A61P11/00 , A61P27/00 , A61P35/00 , A61P37/00 , C07D233/64 , C07D255/04 , C07D273/01 , C07D405/10
摘要： The present invention relates to aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.
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公开(公告)号：US10364256B2
公开(公告)日：2019-07-30
申请号：US15765354
申请日：2016-10-06
发明人： James Callahan , Jeffrey K. Kerns , Peng Li , Tindy Li , Brent W. McCleland , Hong Nie , Joseph E. Pero , Thomas Glanmor Davies , Maria Grazia Carr , Charlotte Mary Griffiths-Jones , Thomas Daniel Heightman , David Norton , Marinus Leendert Verdonk , Alison Jo-Anne Woolford , Hendrika Maria Gerarda Willems
IPC分类号： C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/08 , C07D403/10 , C07D403/14 , C07D405/14 , C07D413/08 , C07D413/14 , C07D417/14 , A61K31/41 , A61K31/4196 , A61K31/445 , A61P11/00 , C07D515/14 , A61K9/00
摘要： The present invention relates to biaryl pyrazole compounds of Formula (I) methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.
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公开(公告)号：US10351530B2
公开(公告)日：2019-07-16
申请号：US15765377
申请日：2016-10-06
发明人： James Callahan , Jeffrey K. Kerns , Tindy Li , Brent W. McCleland , Hong Nie , Joseph E. Pero , Thomas Glanmor Davies , Charlotte Mary Griffiths-Jones , Thomas Daniel Heightman , Steven Howard , David Norton , Marinus Leendert Verdonk , Alison Jo-Anne Woolford
IPC分类号： C07D231/14 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/08 , C07D403/10 , C07D403/14
摘要： The present invention relates to arylcyclohexyl pyrazole compounds of Formula (I) methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.
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公开(公告)号：US20200079759A1
公开(公告)日：2020-03-12
申请号：US16675634
申请日：2019-11-06
发明人： Jeffrey K. KERNS , James Callahan , Hongxing Yan , Thomas Daniel Heightman , Charlotte Mary Griffiths-Jones , Alison Jo-Anne Woolford , Tindy Li , Ami Lakdawala Shah , Roderick S. Davis , David Norton , Jeffrey Charles Boehm , Paris L. Hamilton , Nicole Cathleen Goodwin , Yun Jin
IPC分类号： C07D403/10 , C07D267/14 , C07D249/18 , C07D233/60 , C07D487/08 , C07D451/02 , A61P9/00 , A61P25/00 , A61P11/00 , A61P27/00 , A61P35/00 , A61P37/00 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/10 , C07D403/14 , C07D413/10 , C07D471/04 , C07D487/04 , C07D498/04 , C07D233/64 , C07D255/04 , C07D273/01 , C07D405/10
摘要： The present invention relates to aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.
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公开(公告)号：US20160318917A1
公开(公告)日：2016-11-03
申请号：US15105306
申请日：2014-12-17
发明人： Jeffrey Charles Boehm , Thomas Glanmor Davies , Alison Jo-anne Woolford , Charlotte Mary Griffiths-Jones , Hendrika Maria Gerarda Willems , David Norton , Gordon Saxity , Thomas Daniel Heightman , Tindy Li , Jeffrey K. Kerns , Roderick S. Davis , Hongxing Yan
IPC分类号： C07D417/10 , C07D515/04 , C07D401/12 , C07D513/04 , C07D249/18 , C07D291/08 , C07D471/04 , C07D417/14 , C07D403/12 , C07D419/14 , C07D281/02 , C07D419/10 , C07D405/12
CPC分类号： C07D417/10 , C07D249/18 , C07D281/02 , C07D291/08 , C07D401/12 , C07D403/12 , C07D405/12 , C07D417/14 , C07D419/10 , C07D419/14 , C07D471/04 , C07D513/04 , C07D515/04
摘要： The present invention relates to bis aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators.
摘要翻译： 本发明涉及双芳基类似物，含有它们的药物组合物及其作为Nrf2调节剂的用途。
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