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公开(公告)号：US10144731B2
公开(公告)日：2018-12-04
申请号：US15105306
申请日：2014-12-17
发明人： Thomas Glanmor Davies , Alison Jo-anne Woolford , Hendrika Maria Gerarda Willems , David Norton , Thomas Daniel Heightman , Jeffrey K. Kerns
IPC分类号： C07D249/18 , C07D417/10 , C07D281/02 , C07D291/08 , C07D401/12 , C07D403/12 , C07D405/12 , C07D417/14 , C07D419/10 , C07D419/14 , C07D471/04 , C07D513/04 , C07D515/04
摘要： The present invention relates to bis aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators.
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公开(公告)号：US20160318917A1
公开(公告)日：2016-11-03
申请号：US15105306
申请日：2014-12-17
发明人： Jeffrey Charles Boehm , Thomas Glanmor Davies , Alison Jo-anne Woolford , Charlotte Mary Griffiths-Jones , Hendrika Maria Gerarda Willems , David Norton , Gordon Saxity , Thomas Daniel Heightman , Tindy Li , Jeffrey K. Kerns , Roderick S. Davis , Hongxing Yan
IPC分类号： C07D417/10 , C07D515/04 , C07D401/12 , C07D513/04 , C07D249/18 , C07D291/08 , C07D471/04 , C07D417/14 , C07D403/12 , C07D419/14 , C07D281/02 , C07D419/10 , C07D405/12
CPC分类号： C07D417/10 , C07D249/18 , C07D281/02 , C07D291/08 , C07D401/12 , C07D403/12 , C07D405/12 , C07D417/14 , C07D419/10 , C07D419/14 , C07D471/04 , C07D513/04 , C07D515/04
摘要： The present invention relates to bis aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators.
摘要翻译： 本发明涉及双芳基类似物，含有它们的药物组合物及其作为Nrf2调节剂的用途。
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公开(公告)号：US11643407B2
公开(公告)日：2023-05-09
申请号：US17056495
申请日：2019-05-16
发明人： Jeffrey K. Kerns
IPC分类号： C07D417/10 , C07D249/04 , A61K9/00
CPC分类号： C07D417/10 , C07D249/04 , A61K9/0019 , A61K9/0053
摘要： The present invention relates to indane compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the invention relates to compounds of Formula (I) or Formula (II), and pharmaceutically acceptable salts thereof:
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公开(公告)号：US11117905B2
公开(公告)日：2021-09-14
申请号：US16467193
申请日：2017-12-11
IPC分类号： A61K8/00 , A61K9/00 , C07D243/08 , C07D281/02 , C07D291/08 , C07D513/04 , C07D515/04 , C07D285/36 , C07D409/14
摘要： The present invention relates to bisaryl heterocycle compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the invention relates to bisaryl heterocycles of Formula (I),
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公开(公告)号：US11078216B2
公开(公告)日：2021-08-03
申请号：US16467538
申请日：2017-12-11
发明人： James Francis Callahan , Vincent J. Colandrea , Anthony William James Cooper , Nicole Cathleen Goodwin , Chelsea Ariane Huff , Joel Karpiak , Jeffrey K. Kerns , Hong Nie
IPC分类号： A61K31/554 , A61K31/553 , A61P1/16 , A61P9/00 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/06 , A61P35/00 , C07D281/02 , C07D417/06 , C07D417/12 , C07D417/14 , C07D419/06 , C07D419/12 , C07D419/14 , C07D513/04 , C07D515/04 , C07D401/14
摘要： The present invention relates to bisaryl amide analogs, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the invention relates to bisaryl heterocycles of Formula (I),
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公开(公告)号：US20190224212A1
公开(公告)日：2019-07-25
申请号：US16375047
申请日：2019-04-04
发明人： Jeffrey K. Kerns , James Francis Callahan , Hongxing Yan , Thomas Daniel Heightman , Jeffrey Charles Boehm , Alison Jo-Anne Woolford
IPC分类号： A61K31/5513 , A61K31/421 , A61K31/403 , A61P11/00 , C07D519/00 , C07D403/06 , C07D267/14 , C07D413/10 , C07D413/06 , C07D498/04
摘要： The present invention relates to aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.
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公开(公告)号：US10351530B2
公开(公告)日：2019-07-16
申请号：US15765377
申请日：2016-10-06
发明人： James Callahan , Jeffrey K. Kerns , Tindy Li , Brent W. McCleland , Hong Nie , Joseph E. Pero , Thomas Glanmor Davies , Charlotte Mary Griffiths-Jones , Thomas Daniel Heightman , Steven Howard , David Norton , Marinus Leendert Verdonk , Alison Jo-Anne Woolford
IPC分类号： C07D231/14 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/08 , C07D403/10 , C07D403/14
摘要： The present invention relates to arylcyclohexyl pyrazole compounds of Formula (I) methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.
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公开(公告)号：US20220089590A1
公开(公告)日：2022-03-24
申请号：US17350183
申请日：2021-06-17
发明人： Anthony William James Cooper , Nicole Cathleen Goodwin , Charlotte Mary Griffiths-Jones , Thomas Daniel Heightman , Jeffrey K. Kerns , Hendrika Maria Gerarda Willems , Hongxing Yan
IPC分类号： C07D419/12 , C07D249/04 , C07D401/12 , C07D419/14 , C07D498/04 , C07D513/04
摘要： The present invention relates to ether-linked triazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the invention relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof:
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公开(公告)号：US10604509B2
公开(公告)日：2020-03-31
申请号：US15736075
申请日：2016-06-15
发明人： Jeffrey K. Kerns , James Callahan , Thomas Daniel Heightman , Alison Jo-Anne Woolford , Ami Lakdawala Shah , Roderick S. Davis , David Norton , Jeffrey Charles Boehm , Nicole Cathleen Goodwin
IPC分类号： C07D417/10 , C07D403/10 , C07D249/04 , C07D249/18 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/10 , C07D403/14 , C07D413/10 , C07D471/04 , C07D487/04 , C07D498/04 , C07D267/14 , C07D233/60 , C07D487/08 , C07D451/02 , A61P9/00 , A61P25/00 , A61P11/00 , A61P27/00 , A61P35/00 , A61P37/00 , C07D233/64 , C07D255/04 , C07D273/01 , C07D405/10
摘要： Provided are aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.
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公开(公告)号：US10364256B2
公开(公告)日：2019-07-30
申请号：US15765354
申请日：2016-10-06
发明人： James Callahan , Jeffrey K. Kerns , Peng Li , Tindy Li , Brent W. McCleland , Hong Nie , Joseph E. Pero , Thomas Glanmor Davies , Maria Grazia Carr , Charlotte Mary Griffiths-Jones , Thomas Daniel Heightman , David Norton , Marinus Leendert Verdonk , Alison Jo-Anne Woolford , Hendrika Maria Gerarda Willems
IPC分类号： C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/08 , C07D403/10 , C07D403/14 , C07D405/14 , C07D413/08 , C07D413/14 , C07D417/14 , A61K31/41 , A61K31/4196 , A61K31/445 , A61P11/00 , C07D515/14 , A61K9/00
摘要： The present invention relates to biaryl pyrazole compounds of Formula (I) methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.
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