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公开(公告)号：US20230047296A1
公开(公告)日：2023-02-16
申请号：US17495115
申请日：2021-10-06
发明人： Jeffrey K. KERNS , James Callahan , Hongxing Yan , Thomas Daniel Heightman , Charlotte Mary Griffiths-Jones , Alison Jo-Anne Woolford , Tindy Li , Ami Lakdawala Shah , Roderick S. Davis , David Norton , Jeffrey Charles Boehm , Paris L. Hamilton , Nicole Cathleen Goodwin , Yun Jin
IPC分类号： C07D403/10 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/10 , C07D403/14 , C07D413/10 , C07D471/04 , C07D487/04 , C07D498/04 , C07D267/14 , C07D249/18 , C07D233/60 , C07D487/08 , C07D451/02 , A61P9/00 , A61P25/00 , A61P11/00 , A61P27/00 , A61P35/00 , A61P37/00 , C07D233/64 , C07D255/04 , C07D273/01 , C07D405/10
摘要： The present invention relates to aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.
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公开(公告)号：US10364256B2
公开(公告)日：2019-07-30
申请号：US15765354
申请日：2016-10-06
发明人： James Callahan , Jeffrey K. Kerns , Peng Li , Tindy Li , Brent W. McCleland , Hong Nie , Joseph E. Pero , Thomas Glanmor Davies , Maria Grazia Carr , Charlotte Mary Griffiths-Jones , Thomas Daniel Heightman , David Norton , Marinus Leendert Verdonk , Alison Jo-Anne Woolford , Hendrika Maria Gerarda Willems
IPC分类号： C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/08 , C07D403/10 , C07D403/14 , C07D405/14 , C07D413/08 , C07D413/14 , C07D417/14 , A61K31/41 , A61K31/4196 , A61K31/445 , A61P11/00 , C07D515/14 , A61K9/00
摘要： The present invention relates to biaryl pyrazole compounds of Formula (I) methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.
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公开(公告)号：US10351530B2
公开(公告)日：2019-07-16
申请号：US15765377
申请日：2016-10-06
发明人： James Callahan , Jeffrey K. Kerns , Tindy Li , Brent W. McCleland , Hong Nie , Joseph E. Pero , Thomas Glanmor Davies , Charlotte Mary Griffiths-Jones , Thomas Daniel Heightman , Steven Howard , David Norton , Marinus Leendert Verdonk , Alison Jo-Anne Woolford
IPC分类号： C07D231/14 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/08 , C07D403/10 , C07D403/14
摘要： The present invention relates to arylcyclohexyl pyrazole compounds of Formula (I) methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.
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公开(公告)号：US11059816B2
公开(公告)日：2021-07-13
申请号：US16468777
申请日：2017-12-11
发明人： Anthony William James Cooper , Nicole Cathleen Goodwin , Charlotte Mary Griffiths-Jones , Thomas Daniel Heightman , Jeffrey K. Kerns , Hendrika Maria Gerarda Willems , Hongxing Yan
IPC分类号： A61K31/553 , A61P9/04 , A61P11/00 , C07D498/04 , C07D419/12 , C07D249/04 , C07D401/12 , C07D419/14 , C07D513/04
摘要： The present invention relates to ether-linked triazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the invention relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof:
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公开(公告)号：US20220089590A1
公开(公告)日：2022-03-24
申请号：US17350183
申请日：2021-06-17
发明人： Anthony William James Cooper , Nicole Cathleen Goodwin , Charlotte Mary Griffiths-Jones , Thomas Daniel Heightman , Jeffrey K. Kerns , Hendrika Maria Gerarda Willems , Hongxing Yan
IPC分类号： C07D419/12 , C07D249/04 , C07D401/12 , C07D419/14 , C07D498/04 , C07D513/04
摘要： The present invention relates to ether-linked triazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the invention relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof:
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公开(公告)号：US20200079759A1
公开(公告)日：2020-03-12
申请号：US16675634
申请日：2019-11-06
发明人： Jeffrey K. KERNS , James Callahan , Hongxing Yan , Thomas Daniel Heightman , Charlotte Mary Griffiths-Jones , Alison Jo-Anne Woolford , Tindy Li , Ami Lakdawala Shah , Roderick S. Davis , David Norton , Jeffrey Charles Boehm , Paris L. Hamilton , Nicole Cathleen Goodwin , Yun Jin
IPC分类号： C07D403/10 , C07D267/14 , C07D249/18 , C07D233/60 , C07D487/08 , C07D451/02 , A61P9/00 , A61P25/00 , A61P11/00 , A61P27/00 , A61P35/00 , A61P37/00 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/10 , C07D403/14 , C07D413/10 , C07D471/04 , C07D487/04 , C07D498/04 , C07D233/64 , C07D255/04 , C07D273/01 , C07D405/10
摘要： The present invention relates to aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.
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公开(公告)号：US20160318917A1
公开(公告)日：2016-11-03
申请号：US15105306
申请日：2014-12-17
发明人： Jeffrey Charles Boehm , Thomas Glanmor Davies , Alison Jo-anne Woolford , Charlotte Mary Griffiths-Jones , Hendrika Maria Gerarda Willems , David Norton , Gordon Saxity , Thomas Daniel Heightman , Tindy Li , Jeffrey K. Kerns , Roderick S. Davis , Hongxing Yan
IPC分类号： C07D417/10 , C07D515/04 , C07D401/12 , C07D513/04 , C07D249/18 , C07D291/08 , C07D471/04 , C07D417/14 , C07D403/12 , C07D419/14 , C07D281/02 , C07D419/10 , C07D405/12
CPC分类号： C07D417/10 , C07D249/18 , C07D281/02 , C07D291/08 , C07D401/12 , C07D403/12 , C07D405/12 , C07D417/14 , C07D419/10 , C07D419/14 , C07D471/04 , C07D513/04 , C07D515/04
摘要： The present invention relates to bis aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators.
摘要翻译： 本发明涉及双芳基类似物，含有它们的药物组合物及其作为Nrf2调节剂的用途。
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公开(公告)号：US11866428B2
公开(公告)日：2024-01-09
申请号：US17034926
申请日：2020-09-28
发明人： Alison Jo-Anne Woolford , Steven Howard , Ildiko Maria Buck , Gianni Chessari , Christopher Norbert Johnson , Emiliano Tamanini , James Edward Harvey Day , Elisabetta Chiarparin , Thomas Daniel Heightman , Martyn Frederickson , Charlotte Mary Griffiths-Jones
IPC分类号： C07D471/04 , C07D401/06 , C07D471/10 , C07D403/06 , C07D487/10 , C07D403/14 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/5377 , C07D413/14 , C07D487/04 , C07D519/00
CPC分类号： C07D471/04 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5025 , A61K31/5377 , C07D401/06 , C07D403/06 , C07D403/14 , C07D413/14 , C07D471/10 , C07D487/04 , C07D487/10 , C07D519/00
摘要： The invention relates to bicyclic heterocycle compounds of formula (I):
or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.-
公开(公告)号：US11603367B2
公开(公告)日：2023-03-14
申请号：US16498207
申请日：2018-03-28
发明人： Steven Howard , Jeffrey David St. Denis , Charlotte Mary Griffiths-Jones , Steven Douglas Hiscock , Alan Richard Burns , David Cousin , Kim Louise Hirst , James Daniel Osborne , Jonas Calleja Priede , Aaron Michael Dumas , Brian Christopher Bishop , David Parry-Jones , Jeremy Peter Scott , Meenakshi Sundaram Shanmugham , Peter Richard Mullens , Darren James Dixon , Matthew James Gaunt
IPC分类号： C07D405/06
摘要： The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.
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公开(公告)号：US11643410B2
公开(公告)日：2023-05-09
申请号：US17643083
申请日：2021-12-07
发明人： Gianni Chessari , Christopher Norbert Johnson , Steven Howard , James Edward Harvey Day , Ildiko Maria Buck , Charlotte Mary Griffiths-Jones , Gordon Saxty , Emiliano Tamanini , Nicola Elizabeth Wilsher
IPC分类号： C07D471/04 , A61K31/5377
CPC分类号： C07D471/04 , A61K31/5377
摘要： The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.
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