公开(公告)号：US20220235388A1

公开(公告)日：2022-07-28

申请号：US17657787

申请日：2022-04-04

Applicant: GLYCOM A/S

Inventor： Margit Pedersen ,  Manos Papadakis ,  Peter Becker ,  Eric Samain ,  Pauline Peltier-Pain ,  Katrine Bych ,  Ted Johanson ,  Elise Champion ,  Gyula Dekany

IPC: C12P19/18 ,  C07K14/245 ,  C12N15/52 ,  C12P19/12 ,  C12N9/10 ,  C12N9/12 ,  C12N9/24 ,  C12N9/38

Abstract: The invention relates to a genetically modified microorganism for making a oligosaccharide, preferably of 3-8 monosaccharide units, more preferably of 3-5 monosaccharide units, particularly a HMO, which comprises one or more genes encoding a sucrose utilization system, so the microorganism can use sucrose as a carbon and energy source.

公开(公告)号：US10829508B2

公开(公告)日：2020-11-10

申请号：US16063465

申请日：2016-12-19

Applicant: GLYCOM A/S

Inventor： Manos Papadakis ,  Margit Pedersen ,  Katrine Bych

IPC: C07H3/06 ,  C12P19/18 ,  C12N9/10 ,  C07H1/00 ,  C07H3/02 ,  C12N15/70

Abstract: The invention relates to a microbial production of recombinant oligosaccharides, particularly of human milk oligosaccharides (HMOs), using a genetically modified microorganism, particularly E. coli, in antibiotic-free cultivating medium.

公开(公告)号：US11293042B2

公开(公告)日：2022-04-05

申请号：US16927700

申请日：2020-07-13

Applicant: GLYCOM A/S

Inventor： Margit Pedersen ,  Manos Papadakis ,  Peter Becker ,  Eric Samain ,  Pauline Peltier-Pain ,  Katrine Bych ,  Ted Johanson ,  Elise Champion ,  Gyula Dekany

IPC: C12P19/00 ,  C12P19/12

Abstract: The invention relates to a genetically modified microorganism for making a oligosaccharide, preferably of 3-8 monosaccharide units, more preferably of 3-5 monosaccharide units, particularly a HMO, which comprises one or more genes encoding a sucrose utilization system, so the microorganism can use sucrose as a carbon and energy source.

公开(公告)号：US11608504B2

公开(公告)日：2023-03-21

申请号：US16956092

申请日：2018-12-19

Applicant: GLYCOM A/S

Inventor： Margit Pedersen ,  Manos Papadakis

IPC: C12N15/70 ,  C12N15/113 ,  C12N15/11 ,  C12N15/67

Abstract: The present invention relates to the field of recombining production of biological molecules in host cells. The invention provides nucleic acid constructs that allow to modify expression of a desired gene using both in vitro and in vivo gene expression systems. The constructs can advantageously be used to produce a variety of biological molecules recombinantly in industrial scales, e.g. human milk oligosaccharides (HMO).

公开(公告)号：US11926858B2

公开(公告)日：2024-03-12

申请号：US17657787

申请日：2022-04-04

Applicant: GLYCOM A/S

Inventor： Margit Pedersen ,  Manos Papadakis ,  Peter Becker ,  Eric Samain ,  Pauline Peltier-Pain ,  Katrine Bych ,  Ted Johanson ,  Elise Champion ,  Gyula Dekany

IPC: C12P19/18 ,  C07K14/245 ,  C12N9/10 ,  C12N9/12 ,  C12N9/24 ,  C12N9/38 ,  C12N15/52 ,  C12P19/12

CPC classification number: C12P19/18 ,  C07K14/245 ,  C12N9/1029 ,  C12N9/1051 ,  C12N9/1205 ,  C12N9/2402 ,  C12N9/2471 ,  C12N15/52 ,  C12P19/12 ,  C12Y203/01018 ,  C12Y204/01149 ,  C12Y302/01023 ,  C12Y302/01026 ,  C12Y204/01094

Abstract: The invention relates to a genetically modified microorganism for making a oligosaccharide, preferably of 3-8 monosaccharide units, more preferably of 3-5 monosaccharide units, particularly a HMO, which comprises one or more genes encoding a sucrose utilization system, so the microorganism can use sucrose as a carbon and energy source.