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公开(公告)号：US10981918B2
公开(公告)日：2021-04-20
申请号：US16517080
申请日：2019-07-19
申请人： Grünenthal GmbH
发明人： Florian Jakob , Jo Alen , Simon Lucas , Tobias Craan , Ingo Konetzki , Achim Kless , Stefan Schunk , Paul Ratcliffe , Sebastian Wachten , Simon Cruwys
IPC分类号： C07D487/04
摘要： The present invention relates to compounds according to general formula (I) which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.
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公开(公告)号：US10100041B2
公开(公告)日：2018-10-16
申请号：US15288009
申请日：2016-10-07
申请人： GRÜNENTHAL GMBH
IPC分类号： C07D405/04 , C07D405/14 , C07D409/14
摘要： The invention relates to pyrazolyl substituted tetrahydropyranylsulfones as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
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公开(公告)号：US10106530B2
公开(公告)日：2018-10-23
申请号：US15287947
申请日：2016-10-07
申请人： GRÜNENTHAL GMBH
IPC分类号： C07D405/04 , C07D405/14
摘要： The invention relates to pyrazolyl substituted tetrahydropyranylsulfones as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
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公开(公告)号：US09896440B2
公开(公告)日：2018-02-20
申请号：US14685742
申请日：2015-04-14
申请人： GRÜNENTHAL GMBH
发明人： Stefan Schunk , Melanie Reich , Florian Jakob , René Michael Koenigs , Nils Damann , Michael Haurand , Marc Rogers , Kathy MacKenzie , Richard Hamlyn
IPC分类号： C07D405/04 , C07D309/02 , C07D413/04 , C07D307/18 , C07D405/12 , C07D309/08 , C07D405/10 , C07D407/04
CPC分类号： C07D413/04 , C07D307/18 , C07D309/08 , C07D405/04 , C07D405/10 , C07D405/12 , C07D407/04
摘要： The invention relates to aryl substituted heterocyclyl sulfones as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
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公开(公告)号：US20170101397A1
公开(公告)日：2017-04-13
申请号：US15287947
申请日：2016-10-07
申请人： GRÜNENTHAL GMBH
IPC分类号： C07D405/04 , C07D405/14
CPC分类号： C07D405/04 , C07D405/14
摘要： The invention relates to pyrazolyl substituted tetrahydropyranylsulfones as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
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公开(公告)号：US09302988B2
公开(公告)日：2016-04-05
申请号：US14013081
申请日：2013-08-29
申请人： GRÜNENTHAL GMBH
发明人： Stefan Schunk , Melanie Reich , Henning Steinhagen , Nils Damann , Michael Haurand , Achim Kless , Philip Skone , Richard Hamlyn , Robert Kirby , Marc Rogers , Kathy Sutton
IPC分类号： C07D207/323 , C07D207/34 , C07D403/12 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/06 , C07D487/04
CPC分类号： C07D207/34 , C07D207/323 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/06 , C07D487/04
摘要： The invention relates to pyrrole carboxamides bearing a fluoromethyl-moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
摘要翻译： 本发明涉及带有氟甲基部分作为电压门控钙通道阻断剂的吡咯甲酰胺，含有这些化合物的药物组合物以及用于治疗和/或预防疼痛和其它疾病和/或障碍的这些化合物。
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7.发明授权Fluoromethyl-substituted pyrrole carboxamides as CaV2.2 calcium channel blockers 有权氟甲基取代的吡咯甲酰胺作为CaV2.2钙通道阻断剂公开(公告)号：US09562036B2
公开(公告)日：2017-02-07
申请号：US15185124
申请日：2016-06-17
申请人： GRÜNENTHAL GMBH
发明人： Melanie Reich , Stefan Schunk , Florian Jakob , Henning Steinhagen , Nils Damann , Michael Haurand , Marc Rogers , Kathy MacKenzie
IPC分类号： C07D403/04 , C07D401/04 , C07D409/04 , C07D413/04 , C07D403/14 , C07D413/14
CPC分类号： C07D403/04 , C07D401/04 , C07D403/14 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/14
摘要： The invention relates to pyrrole carboxamides bearing a fluoromethyl-moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
摘要翻译： 本发明涉及带有氟甲基部分作为电压门控钙通道阻断剂的吡咯甲酰胺，含有这些化合物的药物组合物以及用于治疗和/或预防疼痛和其它疾病和/或障碍的这些化合物。
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公开(公告)号：US09879000B2
公开(公告)日：2018-01-30
申请号：US14685732
申请日：2015-04-14
申请人： GRÜNENTHAL GMBH
发明人： Stefan Schunk , Melanie Reich , Florian Jakob , Nils Damann , Michael Haurand , Achim Kless , Marc Rogers , Kathy MacKenzie
IPC分类号： C07D405/04 , C07D309/02 , C07D413/04 , C07D309/08 , C07D405/12
CPC分类号： C07D413/04 , C07D309/08 , C07D405/04 , C07D405/12
摘要： The invention relates to aryl substituted heterocyclyl sulfones as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
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公开(公告)号：US09802921B2
公开(公告)日：2017-10-31
申请号：US15182054
申请日：2016-06-14
申请人： Grünenthal GmbH
发明人： Melanie Reich , Stefan Schunk , Florian Jakob , Henning Steinhagen , Nils Damann , Michael Haurand , Richard Hamlyn , Marc Rogers , Kathy MacKenzie
IPC分类号： C07D401/06 , C07D403/06 , C07D413/06 , C07D417/06 , C07D413/14 , C07D403/04 , C07D403/14
CPC分类号： C07D403/06 , C07D401/06 , C07D403/04 , C07D403/14 , C07D413/06 , C07D413/14 , C07D417/06
摘要： The invention relates to pyrrole carboxamides bearing a fluoromethyl-moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
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公开(公告)号：US12110293B2
公开(公告)日：2024-10-08
申请号：US17152930
申请日：2021-01-20
申请人： GRÜNENTHAL GMBH
发明人： Florian Jakob , Jo Alen , Simon Lucas , Tobias Craan , Ingo Konetzki , Achim Kless , Stefan Schunk , Paul Ratcliffe , Sebastian Wachten , Simon Cruwys
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to compounds according to general formula (I)
which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.
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