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    Pharmaceutical sustained release matrix and process
    1.
    发明授权
    Pharmaceutical sustained release matrix and process 失效
    药物持续释放基质和过程

    公开(公告)号：US5200193A

    公开(公告)日：1993-04-06

    申请号：US600279

    申请日：1990-10-22

    申请人： Galen W. Radebaugh ,  Thomas N. Julian ,  Robert Glinecke

    发明人： Galen W. Radebaugh ,  Thomas N. Julian ,  Robert Glinecke

    IPC分类号： A61K9/20 ,  A61K9/22 ,  A61K9/24 ,  A61K31/19

    CPC分类号： A61K9/209 ,  A61K31/19 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2095

    摘要： A pharmaceutical sustained release homogeneous tablet or homogeneous tablet layer is formed by making a wet granulation using povidone (PVP) in alcohol as the granulating fluid which is mixed with a pharmaceutical active, ethylcellulose, a wicking agent, e.g. microcrystalline cellulose, an erosion promoter, e.g. pregelatinized starch, then drying and milling the granulation and blending with a dry powdered erosion promotor, wicking agent, lubricant, e.g. magnesium stearate and glidant, e.g. silicon dioxide, and compressing the resultant granulation, which upon administration results in a long-lasting slow and relatively regular incremental release of the pharmaceutical active, and multi-layered pharmaceutical active tablets comprising immediate release and/or sustained release layers.

    摘要翻译： 通过在醇中使用聚维酮（PVP）作为制粒流体与药物活性物质，乙基纤维素，芯吸剂例如混合物进行湿法制粒，形成药物缓释均匀片剂或均匀片剂层。 微晶纤维素，侵蚀促进剂，例如。 预胶化淀粉，然后干燥和研磨造粒并与干燥的粉末侵蚀促进剂，芯吸剂，润滑剂， 硬脂酸镁和助流剂，例如 二氧化硅，并且压制所得到的造粒物，其在施用时导致药物活性物质的长期缓慢且相对定期的增量释放，以及包含立即释放和/或持续释放层的多层药物活性片剂。

    Pharmaceutical sustained release matrix
    2.
    发明授权
    Pharmaceutical sustained release matrix 失效
    药物持续释放基质

    公开(公告)号：US5462747A

    公开(公告)日：1995-10-31

    申请号：US373914

    申请日：1995-01-17

    申请人： Galen W. Radebaugh ,  Thomas N. Julian ,  Robert Glinecke

    发明人： Galen W. Radebaugh ,  Thomas N. Julian ,  Robert Glinecke

    IPC分类号： A61K9/20 ,  A61K9/22 ,  A61K9/24 ,  A61K31/19 ,  A61K9/26

    CPC分类号： A61K9/209 ,  A61K31/19 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2095

    摘要： A pharmaceutical sustained release homogeneous tablet or homogeneous tablet layer is formed by making a wet granulation using povidone (PVP) in alcohol as the granulating fluid which is mixed with a pharmaceutical active, ethylcellulose, a wicking agent, e.g. microcrystalline cellulose, an erosion promoter, e.g. pregelatinized starch, then drying and milling the granulation and blending with a dry powdered erosion promotor, wicking agent, lubricant, e.g. magnesium stearate and glidant, e.g. silicon dioxide, and compressing the resultant granulation, which upon administration results in a long-lasting slow and relatively regular incremental release of the pharmaceutical active, and multi-layered pharmaceutical active tablets comprising immediate release and/or sustained release layers.

    摘要翻译： 通过在醇中使用聚维酮（PVP）作为制粒流体与药物活性物质，乙基纤维素，芯吸剂例如混合物进行湿法制粒，形成药物缓释均匀片剂或均匀片剂层。 微晶纤维素，侵蚀促进剂，例如。 预胶化淀粉，然后干燥和研磨造粒并与干燥的粉末侵蚀促进剂，芯吸剂，润滑剂， 硬脂酸镁和助流剂，例如 二氧化硅，并且压制所得到的造粒物，其在施用时导致药物活性物质的长期缓慢且相对定期的增量释放，以及包含立即释放和/或持续释放层的多层药物活性片剂。

    Oral sustained release pharmaceutical formulation and process
    5.
    发明授权
    Oral sustained release pharmaceutical formulation and process 失效
    口服持续释放药物制剂和方法

    公开(公告)号：US5004613A

    公开(公告)日：1991-04-02

    申请号：US392748

    申请日：1989-08-11

    申请人： Galen W. Radebaugh ,  John L. Murtha ,  Robert Glinecke

    发明人： Galen W. Radebaugh ,  John L. Murtha ,  Robert Glinecke

    IPC分类号： A61K9/20 ,  A61K9/22 ,  A61K9/24 ,  A61K31/165

    CPC分类号： A61K31/165 ,  A61K9/2054 ,  A61K9/209 ,  A61K9/2095

    摘要： A pharmaceutical sustained release tablet or tablet layer is formed by making a wet granulation, using povidone (PVP) in water or alcohol-water as the granulating fluid which is mixed with a pharmaceutical active, hydroxyethyl cellulose, a wicking agent e.g. microcrystalline cellulose, then drying and milling the granulation and blending with dry powdered erosion promotor, e.g. pregelantinized starch, additional wicking agent, lubricant e.g. magnesium stearate and glidant e.g. silicon dioxide, and compressing the resultant granulation, which upon administration results in a slow release of the pharmaceutical active.

    摘要翻译： 通过在水或醇 - 水中使用聚维酮（PVP）作为制粒流体，与药物活性羟乙基纤维素，芯吸剂例如聚乙烯吡咯烷酮混合，制成药物缓释片剂或片剂层。 微晶纤维素，然后干燥和研磨造粒并与干粉状侵蚀促进剂共混，例如 预凝胶化淀粉，额外的芯吸剂，润滑剂例如 硬脂酸镁和助流剂 二氧化硅，并压缩所得颗粒，其在施用时导致药物活性物质的缓慢释放。

    Oral sustained release acetaminophen formulation and process
    6.
    发明授权
    Oral sustained release acetaminophen formulation and process 失效
    口服持续释放对乙酰氨基酚的制剂和方法

    公开(公告)号：US4968509A

    公开(公告)日：1990-11-06

    申请号：US299117

    申请日：1989-01-19

    申请人： Galen W. Radebaugh ,  John L. Murtha ,  Robert Glinecke

    发明人： Galen W. Radebaugh ,  John L. Murtha ,  Robert Glinecke

    IPC分类号： A61K9/20 ,  A61K9/24 ,  A61K31/165

    CPC分类号： A61K9/2095 ,  A61K31/165 ,  A61K9/2054 ,  A61K9/209

    摘要： An acetaminophen-sustained release tablet or tablet layer is formed by making a wet granulation, using Povidone (PVP) in water or alcohol-water as the granulating fluid which is mixed with acetaminophen, hydroxyethyl cellulose, a wicking agent e.g. microcrystalline cellulose, then drying and milling the granulation and blending with dry powdered erosion promoter, e.g. pregelatinized starch, wicking agent, lubricant e.g. magnesium stearate and glidant e.g. silicon dioxide, and compressing the resultant granulation, which upon administration results in a slow release of the acetaminophen.

    摘要翻译： 通过使用聚乙烯吡咯烷酮（PVP）在水或醇 - 水中作为造粒流体，与对乙酰氨基酚，羟乙基纤维素，芯吸剂例如混合物进行湿法制粒，形成对乙酰氨基酚缓释片剂或片剂层。 微晶纤维素，然后干燥和研磨造粒并与干粉状侵蚀促进剂共混，例如 预胶化淀粉，芯吸剂，润滑剂例如 硬脂酸镁和助流剂 二氧化硅，并压缩所得颗粒，其在施用时导致对乙酰氨基酚的缓慢释放。

    Oral sustained release pharmaceutical formulation and process
    7.
    发明授权
    Oral sustained release pharmaceutical formulation and process 失效
    口服持续释放药物制剂和工艺

    公开(公告)号：US5073380A

    公开(公告)日：1991-12-17

    申请号：US549860

    申请日：1990-07-09

    申请人： Suresh R. Babu ,  Robert Glinecke ,  John L. Murtha ,  Galen W. Radebaugh

    发明人： Suresh R. Babu ,  Robert Glinecke ,  John L. Murtha ,  Galen W. Radebaugh

    IPC分类号： A61K9/20 ,  A61K9/24 ,  A61K9/26 ,  A61K31/165

    CPC分类号： A61K9/209 ,  A61K31/165 ,  A61K9/2054 ,  A61K9/2095

    摘要： A pharmaceutical sustained release tablet or tablet layer is formed by making a wet granulation, using povidone (PVP) in water or alcohol-water as the granulating fluid which is mixed with a pharmaceutical active, hydroxyethyl cellulose, a wicking agent e.g. microcrystalline cellulose, then drying and milling the granulation and blending with dry powdered smoothness enhancer, e.g. povidone, erosion promoter, e.g. pregelatinized starch, additional wicking agent, lubricant e.g. magnesium stearate and glidant e.g. silicon dioxide, and compressing the resultant granulation into a tablet with a smooth outer surface, which tablet provides, upon administration, a slow release of the pharmaceutical active.

    摘要翻译： 通过在水或醇 - 水中使用聚维酮（PVP）作为制粒流体，与药物活性羟乙基纤维素，芯吸剂例如聚乙烯吡咯烷酮混合，制成药物缓释片剂或片剂层。 微晶纤维素，然后干燥和研磨造粒并与干粉状平滑增强剂混合，例如 聚维酮，侵蚀促进剂，例如 预胶化淀粉，额外的芯吸剂，润滑剂例如 硬脂酸镁和助流剂 二氧化硅，并将所得颗粒压制成具有光滑外表面的片剂，该片剂在施用时提供药物活性物质的缓慢释放。