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1.发明授权Non-C2-symmetric bisphosphine ligands as catalysts for asymmetric hydrogenation 失效非C2对称双膦配体作为不对称氢化的催化剂公开(公告)号：US07414156B2
公开(公告)日：2008-08-19
申请号：US11039611
申请日：2005-01-20
IPC分类号： C07F9/50
CPC分类号： B01J31/2295 , B01J31/24 , B01J31/2409 , B01J31/2414 , B01J31/2433 , B01J31/2452 , B01J31/2457 , B01J31/2476 , B01J31/248 , B01J2231/641 , B01J2231/645 , B01J2531/0266 , B01J2531/822 , C07B53/00 , C07F9/5027 , C07F9/5045 , C07F9/653 , C07F9/65683 , C07F15/0073
摘要： Non-C2-symmetric bisphospholane ligands and methods for their preparation are described. Use of metal/non-C2-symmetric bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.
摘要翻译： 描述了非-C 2对称双硫醇配体及其制备方法。 还描述了使用金属/非C 2 - 对称双磷脂复合物来催化不对称转化反应以提供形成的化合物的高对映异构体过量。
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2.发明授权Synthesis of P-chiral bisphospholane ligands and their transition metal complexes for use as asymmetric hydrogenation catalysts 失效用作不对称氢化催化剂的P-手性双磷酸配体及其过渡金属络合物的合成公开(公告)号：US07230135B2
公开(公告)日：2007-06-12
申请号：US10843031
申请日：2004-05-10
CPC分类号： C07F15/0073 , B01J31/1875 , B01J31/2404 , B01J31/2414 , B01J2231/643 , B01J2231/645 , B01J2531/822 , C07B53/00 , C07B2200/07 , C07F9/6568 , C07F9/65683 , C07F9/65685 , C07F15/00
摘要： P-chiral bisphospholane ligands and methods for their preparation are described. Use of metal/P-chiral bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.
摘要翻译： 描述了P型手性双硫醇配体及其制备方法。 还描述了使用金属/ P-手性双磷脂络合物来催化不对称转化反应以提供形成的化合物的高对映体过量。
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公开(公告)号：US06605745B2
公开(公告)日：2003-08-12
申请号：US10021610
申请日：2001-12-12
IPC分类号： C07F9535
CPC分类号： C07F15/0073 , B01J31/1875 , B01J31/2404 , B01J31/2414 , B01J2231/643 , B01J2231/645 , B01J2531/822 , C07B53/00 , C07B2200/07 , C07F9/6568 , C07F9/65683 , C07F9/65685 , C07F15/00
摘要： P-chiral bisphospholane ligands and methods for their preparation are described. Use of metal/P-chiral bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.
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4.发明授权Synthesis of P-chiral bisphospholane ligands and their transition metal complexes for use as asymmetric hydrogenation catalysts 失效用作不对称氢化催化剂的P-手性双磷酸配体及其过渡金属络合物的合成公开(公告)号：US06750171B2
公开(公告)日：2004-06-15
申请号：US10418684
申请日：2003-04-18
IPC分类号： B01J3124
CPC分类号： C07F15/0073 , B01J31/1875 , B01J31/2404 , B01J31/2414 , B01J2231/643 , B01J2231/645 , B01J2531/822 , C07B53/00 , C07B2200/07 , C07F9/6568 , C07F9/65683 , C07F9/65685 , C07F15/00
摘要： P-chiral bisphospholane ligands and methods for their preparation are described. Use of metal/P-chiral bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.
摘要翻译： 描述了P型手性双硫醇配体及其制备方法。 还描述了使用金属/ P-手性双磷脂络合物来催化不对称转化反应以提供形成的化合物的高对映体过量。
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5.发明授权Non-C2-symmetric bisphosphine ligands as catalysts for asymmetric hydrogenation 失效非C2对称双膦配体作为不对称氢化的催化剂公开(公告)号：US06855849B2
公开(公告)日：2005-02-15
申请号：US10245941
申请日：2002-09-18
IPC分类号： B01J31/24 , C07B51/00 , C07B53/00 , C07B61/00 , C07C253/30 , C07C255/23 , C07F5/02 , C07F9/50 , C07F9/653 , C07F9/6568 , C07F9/90 , C07F15/00 , C07F19/00 , C07E9/02 , C07E9/28
CPC分类号： B01J31/2295 , B01J31/24 , B01J31/2409 , B01J31/2414 , B01J31/2433 , B01J31/2452 , B01J31/2457 , B01J31/2476 , B01J31/248 , B01J2231/641 , B01J2231/645 , B01J2531/0266 , B01J2531/822 , C07B53/00 , C07F9/5027 , C07F9/5045 , C07F9/653 , C07F9/65683 , C07F15/0073
摘要： Non-C2-symmetric bisphospholane ligands and methods for their preparation are described. Use of metal/non-C2-symmetric bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.
摘要翻译： 描述了非C2对称双硫醇配体及其制备方法。 还描述了使用金属/非C2对称双磷脂络合物来催化不对称转化反应以提供形成的化合物的高对映异构体过量。
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6.发明授权Synthesis of non-C2-symmetric bisphosphine ligands as catalysts for asymmetric hydrogenation 失效非C2对称双膦配体作为不对称氢化催化剂的合成公开(公告)号：US06689915B2
公开(公告)日：2004-02-10
申请号：US10083923
申请日：2002-02-27
IPC分类号： C07F950
CPC分类号： B01J31/2295 , B01J31/24 , B01J31/2409 , B01J31/2414 , B01J31/2433 , B01J31/2452 , B01J31/2457 , B01J31/2476 , B01J31/248 , B01J2231/641 , B01J2231/645 , B01J2531/0266 , B01J2531/822 , C07B53/00 , C07F9/5027 , C07F9/5045 , C07F9/653 , C07F9/65683 , C07F15/0073
摘要： Non-C2-symmetric bisphospholane ligands and methods for their preparation are described. Use of metal/non-C2-symmetric bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.
摘要翻译： 描述了非C2对称双硫醇配体及其制备方法。 还描述了使用金属/非C2对称双磷脂络合物来催化不对称转化反应以提供形成的化合物的高对映异构体过量。
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7.发明授权Preparation of P-chirogenic phospholanes and their use in asymmetric synthesis 失效P-氢化磷脂的制备及其在不对称合成中的应用公开(公告)号：US07390931B2
公开(公告)日：2008-06-24
申请号：US11095044
申请日：2005-03-31
IPC分类号： C07F9/02
CPC分类号： C07F9/65685 , C07D327/10 , C07F9/65683 , C07F15/0046
摘要： Materials and methods for preparing P-chirogenic monophospholanes and bisphospholanes are disclosed. The methods employ stereoselective cyclization to generate the phospholane rings followed by pyramidal inversion to access a variety of P-chirogenic phospholanes. When bound to transition metals such as rhodium, the disclosed P-chirogenic phospholanes may be used as catalysts in asymmetric synthesis of valuable pharmaceutical chemical entities, including pregabalin.
摘要翻译： 公开了制备P型氢化单磷脂和二磷脂的材料和方法。 该方法采用立体选择性环化法生成磷脂环，随后进行金字塔反转以获得多种P型氢化磷脂。 当结合到过渡金属如铑时，所公开的P-致动磷脂可用作不对称合成有价值的药物化学实体（包括普瑞巴林）的催化剂。
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