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1.发明授权Synthesis of P-chiral bisphospholane ligands and their transition metal complexes for use as asymmetric hydrogenation catalysts 失效用作不对称氢化催化剂的P-手性双磷酸配体及其过渡金属络合物的合成公开(公告)号：US06750171B2
公开(公告)日：2004-06-15
申请号：US10418684
申请日：2003-04-18
IPC分类号： B01J3124
CPC分类号： C07F15/0073 , B01J31/1875 , B01J31/2404 , B01J31/2414 , B01J2231/643 , B01J2231/645 , B01J2531/822 , C07B53/00 , C07B2200/07 , C07F9/6568 , C07F9/65683 , C07F9/65685 , C07F15/00
摘要： P-chiral bisphospholane ligands and methods for their preparation are described. Use of metal/P-chiral bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.
摘要翻译： 描述了P型手性双硫醇配体及其制备方法。 还描述了使用金属/ P-手性双磷脂络合物来催化不对称转化反应以提供形成的化合物的高对映体过量。
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2.发明授权Non-C2-symmetric bisphosphine ligands as catalysts for asymmetric hydrogenation 失效非C2对称双膦配体作为不对称氢化的催化剂公开(公告)号：US07414156B2
公开(公告)日：2008-08-19
申请号：US11039611
申请日：2005-01-20
IPC分类号： C07F9/50
CPC分类号： B01J31/2295 , B01J31/24 , B01J31/2409 , B01J31/2414 , B01J31/2433 , B01J31/2452 , B01J31/2457 , B01J31/2476 , B01J31/248 , B01J2231/641 , B01J2231/645 , B01J2531/0266 , B01J2531/822 , C07B53/00 , C07F9/5027 , C07F9/5045 , C07F9/653 , C07F9/65683 , C07F15/0073
摘要： Non-C2-symmetric bisphospholane ligands and methods for their preparation are described. Use of metal/non-C2-symmetric bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.
摘要翻译： 描述了非-C 2对称双硫醇配体及其制备方法。 还描述了使用金属/非C 2 - 对称双磷脂复合物来催化不对称转化反应以提供形成的化合物的高对映异构体过量。
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3.发明授权Synthesis of P-chiral bisphospholane ligands and their transition metal complexes for use as asymmetric hydrogenation catalysts 失效用作不对称氢化催化剂的P-手性双磷酸配体及其过渡金属络合物的合成公开(公告)号：US07230135B2
公开(公告)日：2007-06-12
申请号：US10843031
申请日：2004-05-10
CPC分类号： C07F15/0073 , B01J31/1875 , B01J31/2404 , B01J31/2414 , B01J2231/643 , B01J2231/645 , B01J2531/822 , C07B53/00 , C07B2200/07 , C07F9/6568 , C07F9/65683 , C07F9/65685 , C07F15/00
摘要： P-chiral bisphospholane ligands and methods for their preparation are described. Use of metal/P-chiral bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.
摘要翻译： 描述了P型手性双硫醇配体及其制备方法。 还描述了使用金属/ P-手性双磷脂络合物来催化不对称转化反应以提供形成的化合物的高对映体过量。
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公开(公告)号：US06605745B2
公开(公告)日：2003-08-12
申请号：US10021610
申请日：2001-12-12
IPC分类号： C07F9535
CPC分类号： C07F15/0073 , B01J31/1875 , B01J31/2404 , B01J31/2414 , B01J2231/643 , B01J2231/645 , B01J2531/822 , C07B53/00 , C07B2200/07 , C07F9/6568 , C07F9/65683 , C07F9/65685 , C07F15/00
摘要： P-chiral bisphospholane ligands and methods for their preparation are described. Use of metal/P-chiral bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.
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5.发明授权Non-C2-symmetric bisphosphine ligands as catalysts for asymmetric hydrogenation 失效非C2对称双膦配体作为不对称氢化的催化剂公开(公告)号：US06855849B2
公开(公告)日：2005-02-15
申请号：US10245941
申请日：2002-09-18
IPC分类号： B01J31/24 , C07B51/00 , C07B53/00 , C07B61/00 , C07C253/30 , C07C255/23 , C07F5/02 , C07F9/50 , C07F9/653 , C07F9/6568 , C07F9/90 , C07F15/00 , C07F19/00 , C07E9/02 , C07E9/28
CPC分类号： B01J31/2295 , B01J31/24 , B01J31/2409 , B01J31/2414 , B01J31/2433 , B01J31/2452 , B01J31/2457 , B01J31/2476 , B01J31/248 , B01J2231/641 , B01J2231/645 , B01J2531/0266 , B01J2531/822 , C07B53/00 , C07F9/5027 , C07F9/5045 , C07F9/653 , C07F9/65683 , C07F15/0073
摘要： Non-C2-symmetric bisphospholane ligands and methods for their preparation are described. Use of metal/non-C2-symmetric bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.
摘要翻译： 描述了非C2对称双硫醇配体及其制备方法。 还描述了使用金属/非C2对称双磷脂络合物来催化不对称转化反应以提供形成的化合物的高对映异构体过量。
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6.发明授权Synthesis of non-C2-symmetric bisphosphine ligands as catalysts for asymmetric hydrogenation 失效非C2对称双膦配体作为不对称氢化催化剂的合成公开(公告)号：US06689915B2
公开(公告)日：2004-02-10
申请号：US10083923
申请日：2002-02-27
IPC分类号： C07F950
CPC分类号： B01J31/2295 , B01J31/24 , B01J31/2409 , B01J31/2414 , B01J31/2433 , B01J31/2452 , B01J31/2457 , B01J31/2476 , B01J31/248 , B01J2231/641 , B01J2231/645 , B01J2531/0266 , B01J2531/822 , C07B53/00 , C07F9/5027 , C07F9/5045 , C07F9/653 , C07F9/65683 , C07F15/0073
摘要： Non-C2-symmetric bisphospholane ligands and methods for their preparation are described. Use of metal/non-C2-symmetric bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.
摘要翻译： 描述了非C2对称双硫醇配体及其制备方法。 还描述了使用金属/非C2对称双磷脂络合物来催化不对称转化反应以提供形成的化合物的高对映异构体过量。
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公开(公告)号：US06891059B2
公开(公告)日：2005-05-10
申请号：US10182656
申请日：2001-01-11
申请人： Mark Joseph Burk , Om Prakash Goel , Marvin Simon Hoekstra , Thomas Frederick Mich , Thomas Mulhern , James A. Ramsden
发明人： Mark Joseph Burk , Om Prakash Goel , Marvin Simon Hoekstra , Thomas Frederick Mich , Thomas Mulhern , James A. Ramsden
IPC分类号： C07B53/00 , C07B61/00 , C07C227/04 , C07C227/10 , C07C229/08 , C07C253/30 , C07C255/19 , C07C255/23 , C07C255/03
CPC分类号： C07C255/23 , C07C253/30 , C07C255/19
摘要： This invention provides a method of making (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid (pregabalin) or a salt thereof via an asymmetric hydrogenation synthesis. Pregabalin is useful for the treatment and prevention of seizure disorders, pain, and psychotic disorders. The invention also provides intermediates useful in the production of pregabalin.
摘要翻译： 本发明提供了通过不对称氢化合成制备（S） - （+） - 3-（氨基甲基）-5-甲基己酸（普瑞巴林）或其盐的方法。 普瑞巴林可用于治疗和预防癫痫发作，疼痛和精神障碍。 本发明还提供了可用于生产普瑞巴林的中间体。
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公开(公告)号：US06258800B1
公开(公告)日：2001-07-10
申请号：US09601570
申请日：2000-08-03
IPC分类号： A61K31675
CPC分类号： C07D405/12 , C07F9/5728 , C07F9/65586
摘要： The instant invention provides aqueous soluble prodrugs of formula (I) or a pharmaceutically acceptable salt thereof wherein R is —CH2OZ, —C(═O)OCH2OZ or Z, wherein Z is formula (a), —P(═O)(OH)2 or —C(═O)Q: n is an integer of from 0 to 3; m is an integer of from 0 to 1, of certain tachykinin antagonists (NK1 antagonists) useful in the treatment of emesis.
摘要翻译： 本发明提供式（I）的水溶性前药或其药学上可接受的盐，其中R是-CH 2 OZ，-C（= O）OCH 2 OZ或Z，其中Z是式（a），-P（= O） ）2或-C（= O）Q：n为0〜3的整数; m是0至1的整数，可用于治疗呕吐的某些速激肽拮抗剂（NK1拮抗剂）。
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