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1.Mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ACE 失效
标题翻译: 巯基乙酰胺二硫化物衍生物可用作脑啡肽酶和ACE的抑制剂公开(公告)号:US5750521A
公开(公告)日:1998-05-12
申请号:US669521
申请日:1996-11-04
申请人: Gary A. Flynn , Douglas W. Beight , Shujaath Mehdi , Alan M. Warshawsky , John F. French , John H. Kehne
发明人: Gary A. Flynn , Douglas W. Beight , Shujaath Mehdi , Alan M. Warshawsky , John F. French , John H. Kehne
IPC分类号: C07D487/04 , A61K31/55 , A61K38/00 , A61P1/00 , A61P1/12 , A61P5/38 , A61P9/00 , A61P9/12 , A61P13/02 , A61P15/00 , A61P25/04 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/06 , A61P39/02 , A61P43/00 , C07D471/04 , C07D491/052 , C07D498/04 , C07D513/04 , C07K5/078
CPC分类号: C07D471/04 , A61K31/55 , C07K5/06139 , A61K38/00
摘要: The present invention relates to certain mercaptoacetylamide disulfide derivatives of Formula (I) ##STR1## useful as inhibitors of enkephalinase and ACE.
摘要翻译: PCT No.PCT / US94 / 14235 Sec。 371日期:1996年11月4日 102(e)日期1996年11月4日PCT 1994年12月13日PCT PCT。 公开号WO95 / 21839 日期:1995年8月17日本发明涉及可用作脑啡肽酶和ACE抑制剂的式(I)的式(I)的某些巯基乙酰胺二硫化物衍生物。
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2.Mercaptoacetylamino 1,3,4,5-tetrahydro-benzo(C)azepin-2-one disulfide derivatives useful as inhibitors of enkephalinase and ACE 失效
标题翻译: 巯基乙酰氨基1,3,4,5-四氢 - 苯并(C)氮杂-2-酮二硫化物衍生物,可用作脑啡肽酶和ACE的抑制剂公开(公告)号:US5880119A
公开(公告)日:1999-03-09
申请号:US910053
申请日:1997-08-12
申请人: Gary A. Flynn , Douglas W. Beight , Alan M. Warshawsky , Shujaath Mehdi , John F. French , John H. Kehne
发明人: Gary A. Flynn , Douglas W. Beight , Alan M. Warshawsky , Shujaath Mehdi , John F. French , John H. Kehne
IPC分类号: C12N9/99 , A61K38/00 , A61K38/55 , A61P1/04 , A61P7/10 , A61P9/00 , A61P9/12 , A61P25/00 , A61P25/04 , A61P43/00 , C07K1/06 , C07K5/06 , C07K5/078 , A61K31/55 , A01N43/46 , C07D498/04
CPC分类号: C07K5/06139 , A61K38/00
摘要: The present invention relates to certain novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo�c!azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and of ACE.
摘要翻译: 本发明涉及可用作脑啡肽酶和ACE抑制剂的某些新的巯基乙酰氨基1,3,4,5-四氢 - 苯并[c]氮杂-3-酮二硫化物衍生物。
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3.2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ACE 失效
标题翻译: 可用作脑啡肽酶和ACE抑制剂的2-取代的茚满-2-巯基乙酰胺二硫化物衍生物公开(公告)号:US5629309A
公开(公告)日:1997-05-13
申请号:US572326
申请日:1995-12-14
申请人: Gary A. Flynn , Douglas W. Beight , Alan M. Warshawsky , Shujaath Mehdi , John F. French , John H. Kehne
发明人: Gary A. Flynn , Douglas W. Beight , Alan M. Warshawsky , Shujaath Mehdi , John F. French , John H. Kehne
IPC分类号: C12N9/99 , A61K38/00 , A61K38/55 , A61P1/04 , A61P7/10 , A61P9/00 , A61P9/12 , A61P25/00 , A61P25/04 , A61P43/00 , C07K1/06 , C07K5/06 , C07K5/078 , A61K31/33 , C07D223/10
CPC分类号: C07K5/06139 , A61K38/00
摘要: The present invention relates to certain novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and of ACE.
摘要翻译: 本发明涉及可用作脑啡肽酶和ACE抑制剂的某些新型2-取代的茚满-2-巯基乙酰胺二硫化物衍生物。
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4.Mercaptoacetylamido 1,3,4,5-tetrahydro-benzo�c!azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace 失效
标题翻译: 巯基乙酰氨基1,3,4,5-四氢 - 苯并[c]氮杂-3-酮二硫化物衍生物,可用作脑啡肽酶和ace的抑制剂公开(公告)号:US5731306A
公开(公告)日:1998-03-24
申请号:US673250
申请日:1996-06-26
申请人: Gary A. Flynn , Douglas W. Beight , Alan M. Warshawsky , Shujaath Mehdi , John F. French , John H. Kehne
发明人: Gary A. Flynn , Douglas W. Beight , Alan M. Warshawsky , Shujaath Mehdi , John F. French , John H. Kehne
IPC分类号: C12N9/99 , A61K38/00 , A61K38/55 , A61P1/04 , A61P7/10 , A61P9/00 , A61P9/12 , A61P25/00 , A61P25/04 , A61P43/00 , C07K1/06 , C07K5/06 , C07K5/078 , A61K31/55 , C07D498/04
CPC分类号: C07K5/06139 , A61K38/00
摘要: The present invention relates to certain novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo�c!azepin-3-one disulfide derivatives of the formula ##STR1## useful as inhibitors of enkephalinase and of ACE.
摘要翻译: 本发明涉及可用作脑啡肽酶和ACE抑制剂的式“IMAGE”的某些新型巯基乙酰氨基1,3,4,5-四氢 - 苯并[c]氮杂-3-酮二硫化物衍生物。
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5.Indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase 失效
标题翻译: 可用作脑啡肽酶抑制剂的茚满-2-巯基乙酰胺二硫化物衍生物公开(公告)号:US5604221A
公开(公告)日:1997-02-18
申请号:US571022
申请日:1995-12-12
IPC分类号: A61K31/55 , A61P1/00 , A61P5/38 , A61P9/00 , A61P9/12 , A61P13/02 , A61P15/00 , A61P25/04 , A61P25/28 , A61P27/02 , A61P43/00 , C07D471/04 , C07D487/04 , C07D491/052 , C07D498/04 , C07D513/04
CPC分类号: C07D471/04 , C07D487/04 , C07D513/04
摘要: The present invention relates to certain novel indane-2-mercaptoacetylamide disulfide derivatives of the formula ##STR1## useful as inhibitors of enkephalinase.
摘要翻译: 本发明涉及可用作脑啡肽酶抑制剂的式(I)的某些新颖的茚满-2-巯基乙酰胺二硫化物衍生物。
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6.2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ACE 失效
标题翻译: 可用作脑啡肽酶和ACE抑制剂的2-取代的茚满-2-巯基乙酰胺二硫化物衍生物公开(公告)号:US5567814A
公开(公告)日:1996-10-22
申请号:US397304
申请日:1995-03-02
申请人: Gary A. Flynn , Douglas W. Beight , Alan M. Warshawsky , Shujaath Mehdi , John F. French , John H. Kehne
发明人: Gary A. Flynn , Douglas W. Beight , Alan M. Warshawsky , Shujaath Mehdi , John F. French , John H. Kehne
IPC分类号: C12N9/99 , A61K38/00 , A61K38/55 , A61P1/04 , A61P7/10 , A61P9/00 , A61P9/12 , A61P25/00 , A61P25/04 , A61P43/00 , C07K1/06 , C07K5/06 , C07K5/078 , A61K31/33 , C07D223/10
CPC分类号: C07K5/06139 , A61K38/00
摘要: The present invention relates to certain novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and of ACE.
摘要翻译: 本发明涉及可用作脑啡肽酶和ACE抑制剂的某些新型2-取代的茚满-2-巯基乙酰胺二硫化物衍生物。
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7.Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace 失效
标题翻译: 新型巯基乙酰胺衍生物可用作脑啡肽酶抑制剂和ace公开(公告)号:US5430145A
公开(公告)日:1995-07-04
申请号:US149572
申请日:1993-11-09
申请人: Gary A. Flynn , Philippe Bey , Alan M. Warshawsky , Douglas W. Beight , Shujaath Mehdi , Eugene L. Giroux , Timothy P. Burkholder , Edward D. Daugs , John F. French
发明人: Gary A. Flynn , Philippe Bey , Alan M. Warshawsky , Douglas W. Beight , Shujaath Mehdi , Eugene L. Giroux , Timothy P. Burkholder , Edward D. Daugs , John F. French
IPC分类号: A61K38/00 , C07D471/04 , C07D487/04 , C07K5/078 , A61K31/55 , C07D223/16 , C07D498/04 , C07D513/04
CPC分类号: C07D471/04 , C07D487/04 , C07K5/06139 , A61K38/00
摘要: The present invention relates to certain novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and of ACE.
摘要翻译: 本发明涉及可用作脑啡肽酶和ACE抑制剂的某些新型巯基乙酰胺衍生物。
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8.Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace 失效
标题翻译: 巯基乙酰胺衍生物,可用作脑啡肽酶和ace的抑制剂公开(公告)号:US5527795A
公开(公告)日:1996-06-18
申请号:US417179
申请日:1995-04-05
申请人: Gary A. Flynn , Philippe Bey , Alan M. Warshawsky , Douglas W. Beight , Shujaath Mehdi , Eugene L. Giroux , Timothy P. Burkholder , Edward D. Daugs , John F. French
发明人: Gary A. Flynn , Philippe Bey , Alan M. Warshawsky , Douglas W. Beight , Shujaath Mehdi , Eugene L. Giroux , Timothy P. Burkholder , Edward D. Daugs , John F. French
IPC分类号: A61K38/00 , C07D471/04 , C07D487/04 , C07K5/078 , A61K31/55 , C07D457/04
CPC分类号: C07D471/04 , C07D487/04 , C07K5/06139 , A61K38/00
摘要: The present invention relates to certain novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and of ACE.
摘要翻译: 本发明涉及可用作脑啡肽酶和ACE抑制剂的某些新型巯基乙酰胺衍生物。
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9.Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE 失效
标题翻译: 巯基乙酰胺衍生物可用作脑啡肽酶和ACE的抑制剂公开(公告)号:US5491143A
公开(公告)日:1996-02-13
申请号:US417424
申请日:1995-04-05
申请人: Gary A. Flynn , Philippe Bey , Alan M. Warshawsky , Douglas W. Beight , Shujaath Mehdi , Eugene L. Giroux , Timothy P. Burkholder , Edward D. Daugs , John F. French
发明人: Gary A. Flynn , Philippe Bey , Alan M. Warshawsky , Douglas W. Beight , Shujaath Mehdi , Eugene L. Giroux , Timothy P. Burkholder , Edward D. Daugs , John F. French
IPC分类号: A61K38/00 , C07D471/04 , C07D487/04 , C07K5/078 , A61K31/55
CPC分类号: C07D471/04 , C07D487/04 , C07K5/06139 , A61K38/00
摘要: The present invention relates to certain novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and of ACE.
摘要翻译: 本发明涉及可用作脑啡肽酶和ACE抑制剂的某些新型巯基乙酰胺衍生物。
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10.Substituted AZA-indoles as inhibitors of poly(ADP-ribose) polymerase (PARP) 失效
标题翻译: 取代的AZA-吲哚作为聚(ADP-核糖)聚合酶(PARP)的抑制剂,公开(公告)号:US08008491B2
公开(公告)日:2011-08-30
申请号:US12140632
申请日:2008-06-17
申请人: John Ziqi Jiang , Jack Roger Koehl , Shujaath Mehdi , Neil Moorcroft , Kwon Yon Musick , Philip Marvin Weintraub , Paul Robert Eastwood
发明人: John Ziqi Jiang , Jack Roger Koehl , Shujaath Mehdi , Neil Moorcroft , Kwon Yon Musick , Philip Marvin Weintraub , Paul Robert Eastwood
IPC分类号: C07D403/04 , C07D209/04
CPC分类号: C04B35/632 , A61K31/404 , A61K31/454 , A61K31/4745 , A61K31/496 , A61K31/503 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D209/40 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D405/12 , C07D405/14 , C07D409/04 , C07D471/04 , C07D487/08
摘要: The present invention relates to a series of substituted aza-indole derivatives of the formula I: wherein R, R1, R2, R3, R4, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5′-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.
摘要翻译: 本发明涉及一系列式I的取代的氮杂 - 吲哚衍生物:其中R,R 1,R 2,R 3,R 4,X和Y如本文所定义。 本发明还涉及制备这些化合物的方法。 本发明的化合物是聚(腺苷5'-二磷酸核糖)聚合酶(PARP)的抑制剂,因此可用作药剂,特别是用于治疗和/或预防各种疾病,包括与中枢神经相关的疾病 系统和心血管疾病。
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