利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

11 条记录 (耗时 0.049 秒)

    Process for the synthesis of CXCR4 antagonist
    7.
    发明申请
    Process for the synthesis of CXCR4 antagonist 有权
    合成CXCR4拮抗剂的方法

    公开(公告)号：US20050209277A1

    公开(公告)日：2005-09-22

    申请号：US11077896

    申请日：2005-03-11

    申请人： Jason Crawford ,  Gang Chen ,  David Gauthier ,  Renato Skerlj ,  Ian Baird ,  Trevor Wilson

    发明人： Jason Crawford ,  Gang Chen ,  David Gauthier ,  Renato Skerlj ,  Ian Baird ,  Trevor Wilson

    IPC分类号： A61K31/4709 ,  C07D215/38 ,  C07D215/40 ,  C07D401/12 ,  C07D401/14 ,  C07D43/02

    CPC分类号： C07D401/14 ,  C07D215/40 ,  C07D401/12 ,  Y02P20/55

    摘要： This invention relates to a process for synthesizing heterocyclic pharmaceutical compound which binds to the CXCR4 chemokine receptor. In one embodiment, the process comprises: a) reacting a 5,6,7,8-tetrahydroquinolinylamine and an alkyl aldehyde bearing a phthalimide or a di-tertiary-butoxycarbonyl (di-BOC) protecting group to form an imine; b) reducing the imine to form a secondary amine; c) reacting the secondary amine with a haloalkyl substituted heterocyclic compound, to form a phthalimido-protected or di-tert-butoxycarbonyl protected tertiary amine; and d) hydrolyzing the protected amine to obtain a compound having Formula I′

    摘要翻译： 本发明涉及一种结合CXCR4趋化因子受体的杂环药物化合物的合成方法。 在一个实施方案中，该方法包括：a）使5,6,7,8-四氢喹啉基胺和带有邻苯二甲酰亚胺或二叔丁氧基羰基（二-BOC）保护基团的烷基醛反应以形成亚胺; b）还原亚胺以形成仲胺; c）使仲胺与卤代烷基取代的杂环化合物反应，形成邻苯二甲酰亚氨基保护或二叔丁氧羰基保护的叔胺; 和d）水解受保护的胺以获得具有式I'

    CAR TELEPHONE SYSTEM
    8.
    发明申请
    CAR TELEPHONE SYSTEM 有权
    汽车电话系统

    公开(公告)号：US20070142095A1

    公开(公告)日：2007-06-21

    申请号：US11425178

    申请日：2006-06-20

    申请人： Eckhard Bollmann ,  Trevor Wilson

    发明人： Eckhard Bollmann ,  Trevor Wilson

    IPC分类号： H04M1/00

    CPC分类号： H04M1/6091

    摘要： A car telephone system having a telephone module (3) which has a telephone transmitting and receiving unit (5), can be connected to a transmitting and receiving antenna (7), can be connected to a central control bus (1) of the vehicle and can be controlled by a central controller (2) via the control bus (1) enables telephone operation, via the telephone module (3), using user-specific data from a mobile telephone (9) by virtue of the fact that the telephone transmitting and receiving unit (5) is provided with a wireless data and signal transmission unit (6) which can be used to transmit user-specific data from a mobile telephone (9) to the telephone transmitting and receiving unit (5), and by virtue of the fact that the telephone transmitting and receiving unit (5) is also connected to a separate card reader (11) for a memory card which contains the user-specific data from the mobile telephone (9).

    摘要翻译： 具有具有电话发送和接收单元（5）的电话模块（3）的汽车电话系统可以连接到发送和接收天线（7），可以连接到车辆的中央控制总线（1） 并且可以经由控制总线（1）由中央控制器（2）控制，使得经由电话模块（3）的电话操作可以利用来自移动电话（9）的用户特定数据，凭借电话 发送和接收单元（5）设置有无线数据和信号传输单元（6），其可以用于将用户特定的数据从移动电话（9）发送到电话发送和接收单元（5），并且通过 凭借电话发送和接收单元（5）也连接到包含来自移动电话（9）的用户特定数据的存储卡的单独读卡器（11）的事实。

    Car telephone system
    9.
    发明授权
    Car telephone system 有权
    汽车电话系统

    公开(公告)号：US07702312B2

    公开(公告)日：2010-04-20

    申请号：US11425178

    申请日：2006-06-20

    申请人： Eckhard Bollmann ,  Trevor Wilson

    发明人： Eckhard Bollmann ,  Trevor Wilson

    IPC分类号： H04M1/00

    CPC分类号： H04M1/6091

    摘要： A car telephone system having a telephone module (3) which has a telephone transmitting and receiving unit (5), can be connected to a transmitting and receiving antenna (7), can be connected to a central control bus (1) of the vehicle and can be controlled by a central controller (2) via the control bus (1) enables telephone operation, via the telephone module (3), using user-specific data from a mobile telephone (9) by virtue of the fact that the telephone transmitting and receiving unit (5) is provided with a wireless data and signal transmission unit (6) which can be used to transmit user-specific data from a mobile telephone (9) to the telephone transmitting and receiving unit (5), and by virtue of the fact that the telephone transmitting and receiving unit (5) is also connected to a separate card reader (11) for a memory card which contains the user-specific data from the mobile telephone (9).

    摘要翻译： 具有具有电话发送和接收单元（5）的电话模块（3）的汽车电话系统可以连接到发送和接收天线（7），可以连接到车辆的中央控制总线（1） 并且可以经由控制总线（1）由中央控制器（2）控制，使得经由电话模块（3）的电话操作可以利用来自移动电话（9）的用户特定数据，凭借电话 发送和接收单元（5）设置有无线数据和信号传输单元（6），其可以用于将用户特定的数据从移动电话（9）发送到电话发送和接收单元（5），并且通过 凭借电话发送和接收单元（5）也连接到包含来自移动电话（9）的用户特定数据的存储卡的单独读卡器（11）的事实。