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公开(公告)号：US20120009142A1
公开(公告)日：2012-01-12
申请号：US13158653
申请日：2011-06-13
申请人： Gary Mitchell Karp , Peter Seongwoo Hwang , James Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Christine Espiritu , Concetta Freund , Zhengxian Gu , Takashi Komatsu
发明人： Gary Mitchell Karp , Peter Seongwoo Hwang , James Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Christine Espiritu , Concetta Freund , Zhengxian Gu , Takashi Komatsu
IPC分类号： A61K38/20 , C07D401/10 , C07D409/06 , C07D403/10 , A61P31/14 , A61K31/454 , A61K31/4178 , A61K38/21 , A61K31/7056 , C07D209/40 , A61K31/404
CPC分类号： A61K31/404 , A61K31/405 , A61K31/4439 , Y02A50/465
摘要： In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the treatment or prevention of a viral infection are provided. In another aspect of the invention, compounds useful in the treatment or prevention of HCV infection are provided.
摘要翻译： 根据本发明，已经鉴定了抑制病毒复制的化合物，优选丙型肝炎病毒（HCV）复制，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于治疗或预防病毒感染的化合物。 在本发明的另一方面，提供了可用于治疗或预防HCV感染的化合物。
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公开(公告)号：US08013006B2
公开(公告)日：2011-09-06
申请号：US11180961
申请日：2005-07-14
申请人： Gary Mitchell Karp , Peter Seongwoo Hwang , James Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Christine Espiritu , Concetta Freund , Zhengxian Gu , Takashi Komatsu
发明人： Gary Mitchell Karp , Peter Seongwoo Hwang , James Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Christine Espiritu , Concetta Freund , Zhengxian Gu , Takashi Komatsu
IPC分类号： A01N43/38 , A61K31/405 , C07D209/04
CPC分类号： A61K31/404 , A61K31/405 , A61K31/4439 , Y02A50/465
摘要： In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the treatment or prevention of a viral infection are provided. In another aspect of the invention, compounds useful in the treatment or prevention of HCV infection are provided.
摘要翻译： 根据本发明，已经鉴定了抑制病毒复制的化合物，优选丙型肝炎病毒（HCV）复制，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于治疗或预防病毒感染的化合物。 在本发明的另一方面，提供了可用于治疗或预防HCV感染的化合物。
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公开(公告)号：US20080096928A9
公开(公告)日：2008-04-24
申请号：US11180961
申请日：2005-07-14
申请人： Gary Karp , Peter Hwang , James Takasugi , Hongyu Ren , Richard Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Campbell
发明人： Gary Karp , Peter Hwang , James Takasugi , Hongyu Ren , Richard Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Campbell
IPC分类号： A61K31/4439 , A61K31/405
CPC分类号： A61K31/404 , A61K31/405 , A61K31/4439 , Y02A50/465
摘要： In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the treatment or prevention of a viral infection are provided. In another aspect of the invention, compounds useful in the treatment or prevention of HCV infection are provided.
摘要翻译： 根据本发明，已经鉴定了抑制病毒复制的化合物，优选丙型肝炎病毒（HCV）复制，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于治疗或预防病毒感染的化合物。 在本发明的另一方面，提供了可用于治疗或预防HCV感染的化合物。
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公开(公告)号：US20060223863A1
公开(公告)日：2006-10-05
申请号：US11180961
申请日：2005-07-14
申请人： Gary Karp , Peter Hwang , James Takasugi , Hongyu Ren , Richard Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Campbell
发明人： Gary Karp , Peter Hwang , James Takasugi , Hongyu Ren , Richard Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Campbell
IPC分类号： A61K31/4439 , A61K31/405
CPC分类号： A61K31/404 , A61K31/405 , A61K31/4439 , Y02A50/465
摘要： In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the treatment or prevention of a viral infection are provided. In another aspect of the invention, compounds useful in the treatment or prevention of HCV infection are provided.
摘要翻译： 根据本发明，已经鉴定了抑制病毒复制的化合物，优选丙型肝炎病毒（HCV）复制，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于治疗或预防病毒感染的化合物。 在本发明的另一方面，提供了可用于治疗或预防HCV感染的化合物。
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公开(公告)号：US20070299068A1
公开(公告)日：2007-12-27
申请号：US11653448
申请日：2007-01-16
申请人： Gary Karp , Peter Hwang , James Takasugi , Hongyu Ren , Richard Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Campbell
发明人： Gary Karp , Peter Hwang , James Takasugi , Hongyu Ren , Richard Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Campbell
IPC分类号： A61K31/404 , A61K31/4178 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/5377 , A61P31/12 , C07D209/10 , C07D271/06 , C07D401/10 , C07D403/10 , C07D403/12 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/10
CPC分类号： C07D209/30 , C07D209/14 , C07D209/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
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公开(公告)号：US20060189606A1
公开(公告)日：2006-08-24
申请号：US11331180
申请日：2006-01-13
申请人： Gary Karp , Peter Hwang , James Takasugi , Hongyu Ren , Richard Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Campbell
发明人： Gary Karp , Peter Hwang , James Takasugi , Hongyu Ren , Richard Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Campbell
IPC分类号： A61K31/538 , A61K31/496 , A61K31/404 , C07D413/02 , C07D403/02
CPC分类号： C07D403/12 , C07D209/14 , C07D209/42 , C07D401/12 , C07D403/10 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
摘要翻译： 本发明提供化合物，药物组合物和使用这些化合物或组合物治疗病毒感染或影响病毒IRES活性的方法。
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公开(公告)号：US20070299069A1
公开(公告)日：2007-12-27
申请号：US11653450
申请日：2007-01-16
申请人： Gary Karp , Peter Hwang , James Takasugi , Hongyu Ren , Richard Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Campbell
发明人： Gary Karp , Peter Hwang , James Takasugi , Hongyu Ren , Richard Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Campbell
IPC分类号： A61K31/404 , A61K31/4178 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/5377 , A61P31/12 , C07D209/10 , C07D271/06 , C07D401/10 , C07D403/10 , C07D403/12 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/10
CPC分类号： C07D209/30 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
摘要翻译： 本发明提供化合物，药物组合物和使用这些化合物或组合物治疗病毒感染或影响病毒IRES活性的方法。
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公开(公告)号：US08735414B2
公开(公告)日：2014-05-27
申请号：US13259717
申请日：2010-04-05
申请人： Malcolm MacCoss , F. George Njoroge , Amin Nomeir , Guangming Chen , Song Xiao Huang , Ramesh Kakarla , Gary Mitchell Karp , William Joseph Lennox , Chunshi Li , Ronggang Liu , Yalei Liu , Christie Morrill , Steven D. Paget , Sean W Smith , James Takasugi , Anthony A. Turpoff , Hongyu Ren , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
发明人： Malcolm MacCoss , F. George Njoroge , Amin Nomeir , Guangming Chen , Song Xiao Huang , Ramesh Kakarla , Gary Mitchell Karp , William Joseph Lennox , Chunshi Li , Ronggang Liu , Yalei Liu , Christie Morrill , Steven D. Paget , Sean W Smith , James Takasugi , Anthony A. Turpoff , Hongyu Ren , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
IPC分类号： A61K31/506 , C07D401/02 , C07D405/02 , C07D209/04
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention is directed to compounds and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.
摘要翻译： 本发明涉及用于治疗病毒感染或通过调节病毒复制影响病毒活性的化合物及其形式和药物组合物。
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公开(公告)号：US20120184574A1
公开(公告)日：2012-07-19
申请号：US13259717
申请日：2010-04-05
申请人： Malcolm Maccoss , F. George Njoroge , Amin Nomeir , Guangming Chen , Song Xiao Huang , Ramesh Kakarla , Gary Mitchell Karp , William Joseph Lennox , Chunshi Li , Ronggang Liu , Yalei Liu , Christie Morrill , Steven D. Paget , Sean W. Smith , James Takasugi , Anthony A. Turpoff , Hongyu Ren , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
发明人： Malcolm Maccoss , F. George Njoroge , Amin Nomeir , Guangming Chen , Song Xiao Huang , Ramesh Kakarla , Gary Mitchell Karp , William Joseph Lennox , Chunshi Li , Ronggang Liu , Yalei Liu , Christie Morrill , Steven D. Paget , Sean W. Smith , James Takasugi , Anthony A. Turpoff , Hongyu Ren , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
IPC分类号： A61K31/4439 , C07D401/14 , A61K31/444 , A61P31/20 , A61P31/12 , A61P31/22 , A61P31/18 , A61P31/14 , C07D401/04 , A61K31/506
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention is directed to compounds and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.
摘要翻译： 本发明涉及用于治疗病毒感染或通过调节病毒复制影响病毒活性的化合物及其形式和药物组合物。
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10.发明申请Ureido substituted benzoic acid compounds and their use for nonsense suppression and the treatment of disease 有权脲基取代的苯甲酸化合物及其用于无意义抑制和治疗疾病的用途公开(公告)号：US20060167065A1
公开(公告)日：2006-07-27
申请号：US11048656
申请日：2005-01-21
申请人： Richard Wilde , James Takasugi , Seongwoo Hwang , Ellen Welch , Guangming Chen
发明人： Richard Wilde , James Takasugi , Seongwoo Hwang , Ellen Welch , Guangming Chen
IPC分类号： A61K31/426 , A61K31/421 , A61K31/4196 , A61K31/4172
CPC分类号： C07D285/16 , A61K31/17 , A61K31/4166 , A61K31/4172 , A61K31/4196 , A61K31/421 , A61K31/426 , C07C275/42 , C07D233/32 , C07D233/42 , C07D233/72 , C07D401/04 , C07D401/10 , C07D405/04 , C07D405/06 , C07D409/04
摘要： The invention encompasses ureido substituted benzoic acid compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these compounds or compositions.
摘要翻译： 本发明包括脲基取代的苯甲酸化合物，包含该化合物的组合物和通过施用这些化合物或组合物来治疗或预防与无义突变mRNA相关的疾病的方法。
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