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公开(公告)号：US20110268698A1
公开(公告)日：2011-11-03
申请号：US13158692
申请日：2011-06-13
Applicant: Gary M. KARP , Peter Seongwoo HWANG , James J. TAKASUGI , Hongyu REN , Richard Gerald WILDE , Anthony A. TURPOFF , Alexander AREFOLOV , Guangming CHEN , Jeffrey Allen CAMPBELL , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
Inventor： Gary M. KARP , Peter Seongwoo HWANG , James J. TAKASUGI , Hongyu REN , Richard Gerald WILDE , Anthony A. TURPOFF , Alexander AREFOLOV , Guangming CHEN , Jeffrey Allen CAMPBELL , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
IPC: A61K38/21
CPC classification number: C07D209/30 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14
Abstract: The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IBES activity.
Abstract translation: 本发明提供化合物，药物组合物和使用这些化合物或组合物治疗病毒感染或影响病毒IBES活性的方法。
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公开(公告)号：US20080096928A9
公开(公告)日：2008-04-24
申请号：US11180961
申请日：2005-07-14
Applicant: Gary Karp , Peter Hwang , James Takasugi , Hongyu Ren , Richard Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Campbell
Inventor： Gary Karp , Peter Hwang , James Takasugi , Hongyu Ren , Richard Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Campbell
IPC: A61K31/4439 , A61K31/405
CPC classification number: A61K31/404 , A61K31/405 , A61K31/4439 , Y02A50/465
Abstract: In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the treatment or prevention of a viral infection are provided. In another aspect of the invention, compounds useful in the treatment or prevention of HCV infection are provided.
Abstract translation: 根据本发明，已经鉴定了抑制病毒复制的化合物，优选丙型肝炎病毒（HCV）复制，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于治疗或预防病毒感染的化合物。 在本发明的另一方面，提供了可用于治疗或预防HCV感染的化合物。
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公开(公告)号：US20060223863A1
公开(公告)日：2006-10-05
申请号：US11180961
申请日：2005-07-14
Applicant: Gary Karp , Peter Hwang , James Takasugi , Hongyu Ren , Richard Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Campbell
Inventor： Gary Karp , Peter Hwang , James Takasugi , Hongyu Ren , Richard Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Campbell
IPC: A61K31/4439 , A61K31/405
CPC classification number: A61K31/404 , A61K31/405 , A61K31/4439 , Y02A50/465
Abstract: In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the treatment or prevention of a viral infection are provided. In another aspect of the invention, compounds useful in the treatment or prevention of HCV infection are provided.
Abstract translation: 根据本发明，已经鉴定了抑制病毒复制的化合物，优选丙型肝炎病毒（HCV）复制，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于治疗或预防病毒感染的化合物。 在本发明的另一方面，提供了可用于治疗或预防HCV感染的化合物。
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公开(公告)号：US09193989B2
公开(公告)日：2015-11-24
申请号：US13163192
申请日：2011-06-17
Applicant: Eun Sun Park , Henry E. Pelish , Astrid S. Clarke , Grace L. Williams , Maria Paola Castaldi , Alexander Arefolov , Jennifer E. Ring , Matthew D. Shair , Randall W. King
Inventor： Eun Sun Park , Henry E. Pelish , Astrid S. Clarke , Grace L. Williams , Maria Paola Castaldi , Alexander Arefolov , Jennifer E. Ring , Matthew D. Shair , Randall W. King
IPC: C12Q1/48
CPC classification number: C12Q1/485 , G01N2500/02
Abstract: The present invention provides methods of identifying an agent that modulates PRPK, TPRKB, OSGEP, LAGE3 and its homologs, PRPK/TPRKB complex, and/or KEOPS complex. The present invention also provides compositions of such agents and methods of treating a disease, disorder, or condition associated with PRPK, TPRKB, OSGEP, LAGE3 and its homologs family (CT antigens), PRPK/TPRKB complex, and/or KEOPS complex using such an agent or composition.
Abstract translation: 本发明提供鉴定调节PRPK，TPRKB，OSGEP，LAGE3及其同源物，PRPK / TPRKB复合物和/或KEOPS复合物的试剂的方法。 本发明还提供了这样的药剂组合物和治疗与PRPK，TPRKB，OSGEP，LAGE3及其同系物家族（CT抗原），PRPK / TPRKB复合物和/或KEOPS复合物相关的疾病，病症或病症的方法 代理或组合。
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公开(公告)号：US08013006B2
公开(公告)日：2011-09-06
申请号：US11180961
申请日：2005-07-14
Applicant: Gary Mitchell Karp , Peter Seongwoo Hwang , James Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Christine Espiritu , Concetta Freund , Zhengxian Gu , Takashi Komatsu
Inventor： Gary Mitchell Karp , Peter Seongwoo Hwang , James Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Christine Espiritu , Concetta Freund , Zhengxian Gu , Takashi Komatsu
IPC: A01N43/38 , A61K31/405 , C07D209/04
CPC classification number: A61K31/404 , A61K31/405 , A61K31/4439 , Y02A50/465
Abstract: In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the treatment or prevention of a viral infection are provided. In another aspect of the invention, compounds useful in the treatment or prevention of HCV infection are provided.
Abstract translation: 根据本发明，已经鉴定了抑制病毒复制的化合物，优选丙型肝炎病毒（HCV）复制，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于治疗或预防病毒感染的化合物。 在本发明的另一方面，提供了可用于治疗或预防HCV感染的化合物。
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Patent Agency Ranking
公开(公告)号：US07781478B2
公开(公告)日：2010-08-24
申请号：US11653450
申请日：2007-01-16
Applicant: Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Jin Zhu , Xiaoyan Zhang
Inventor： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Jin Zhu , Xiaoyan Zhang
IPC: C07D209/10 , A61K31/404
CPC classification number: C07D209/30 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14
Abstract: The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
Abstract translation: 本发明提供化合物，药物组合物和使用这些化合物或组合物治疗病毒感染或影响病毒IRES活性的方法。
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公开(公告)号：US20070299069A1
公开(公告)日：2007-12-27
申请号：US11653450
申请日：2007-01-16
Applicant: Gary Karp , Peter Hwang , James Takasugi , Hongyu Ren , Richard Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Campbell
Inventor： Gary Karp , Peter Hwang , James Takasugi , Hongyu Ren , Richard Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Campbell
IPC: A61K31/404 , A61K31/4178 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/5377 , A61P31/12 , C07D209/10 , C07D271/06 , C07D401/10 , C07D403/10 , C07D403/12 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/10
CPC classification number: C07D209/30 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14
Abstract: The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
Abstract translation: 本发明提供化合物，药物组合物和使用这些化合物或组合物治疗病毒感染或影响病毒IRES活性的方法。
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公开(公告)号：US20120009142A1
公开(公告)日：2012-01-12
申请号：US13158653
申请日：2011-06-13
Applicant: Gary Mitchell Karp , Peter Seongwoo Hwang , James Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Christine Espiritu , Concetta Freund , Zhengxian Gu , Takashi Komatsu
Inventor： Gary Mitchell Karp , Peter Seongwoo Hwang , James Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Christine Espiritu , Concetta Freund , Zhengxian Gu , Takashi Komatsu
IPC: A61K38/20 , C07D401/10 , C07D409/06 , C07D403/10 , A61P31/14 , A61K31/454 , A61K31/4178 , A61K38/21 , A61K31/7056 , C07D209/40 , A61K31/404
CPC classification number: A61K31/404 , A61K31/405 , A61K31/4439 , Y02A50/465
Abstract: In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the treatment or prevention of a viral infection are provided. In another aspect of the invention, compounds useful in the treatment or prevention of HCV infection are provided.
Abstract translation: 根据本发明，已经鉴定了抑制病毒复制的化合物，优选丙型肝炎病毒（HCV）复制，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于治疗或预防病毒感染的化合物。 在本发明的另一方面，提供了可用于治疗或预防HCV感染的化合物。
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公开(公告)号：US07973069B2
公开(公告)日：2011-07-05
申请号：US12814755
申请日：2010-06-14
Applicant: Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Jin Zhu , Xiaoyan Zhang
Inventor： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Jin Zhu , Xiaoyan Zhang
IPC: C07D209/10 , A61K31/404
CPC classification number: C07D209/30 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14
Abstract: The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
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公开(公告)号：US20100305100A1
公开(公告)日：2010-12-02
申请号：US12828597
申请日：2010-07-01
Applicant: Gary Mitchell Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
Inventor： Gary Mitchell Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
IPC: A61K31/55 , C07D209/04 , C07D417/06 , C07D405/12 , C07D271/10 , C07D403/04 , C07D263/30 , C07D401/12 , C07D239/10 , C07D215/00 , C07D223/16 , A61K31/405 , A61K31/40 , A61K31/4155 , A61K31/4245 , A61K31/427 , A61K31/42 , A61K31/4439 , A61K31/497 , A61K31/4725 , A61P31/14 , A61P31/12
CPC classification number: C07D209/30 , C07D209/14 , C07D209/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14
Abstract: The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
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