公开(公告)号：US20070054990A1

公开(公告)日：2007-03-08

申请号：US11462813

申请日：2006-08-07

申请人： Jeffrey RUBERTI ,  Gavin BRAITHWAITE

发明人： Jeffrey RUBERTI ,  Gavin BRAITHWAITE

IPC分类号： A61F2/44

CPC分类号： A61F2/442 ,  A61F2002/444 ,  A61L27/16 ,  A61L27/52 ,  A61L2430/38 ,  C08J3/09 ,  C08J2329/04 ,  C08L29/04 ,  Y10S516/902 ,  Y10S524/916 ,  C08L2666/26

摘要： In preferred embodiments, the present invention provides methods of controllably making a vinyl polymer hydrogel having desired physical properties without chemical cross links or radiation. The gelation process is modulated by controlling, for example, the temperature of a resultant vinyl polymer mixture having a gellant or using active ingredients provided in an inactive gellant complex. In accordance with a preferred embodiment, the method of manufacturing a vinyl polymer hydrogel includes the steps of providing a vinyl polymer solution comprising a vinyl polymer dissolved in a first solvent; heating the vinyl polymer solution to a temperature elevated above the melting point of the physical associations of the vinyl polymer, mixing the vinyl polymer solution with a gellant, wherein the resulting mixture has a higher Flory interaction parameter than the vinyl polymer solution; inducing gelation of the mixture of vinyl polymer solution and gellant; and controlling the gelation rate to form a viscoelastic solution, wherein workability is maintained for a predetermined period, thereby making a vinyl polymer hydrogel having the desired physical property. In further preferred embodiments, the present invention provides physically crosslinked hydrogels produced by controlled gelation of viscoelastic solution wherein workability is maintained for a predetermined period. In another aspect, the present invention provides kits for use in repairing intervertebral disks or articulated joints including components that form the vinyl polymer hydrogel and a dispenser.

摘要翻译： 在优选的实施方案中，本发明提供了可控地制备具有所需物理性质而没有化学交联或辐射的乙烯基聚合物水凝胶的方法。 通过控制例如具有胶凝剂的所得乙烯基聚合物混合物的温度或使用在非活性胶凝剂络合物中提供的活性成分来调节凝胶化过程。 根据优选实施方案，制备乙烯基聚合物水凝胶的方法包括以下步骤：提供包含溶解在第一溶剂中的乙烯基聚合物的乙烯基聚合物溶液; 将乙烯基聚合物溶液加热到高于乙烯基聚合物的物理缔合的熔点的温度，将乙烯基聚合物溶液与胶凝剂混合，其中所得混合物具有比乙烯基聚合物溶液更高的Flory相互作用参数; 引起乙烯基聚合物溶液和胶凝剂混合物的凝胶化; 并控制凝胶化速率以形成粘弹性溶液，其中可加工性保持预定时间，从而制备具有所需物理性能的乙烯基聚合物水凝胶。 在进一步优选的实施方案中，本发明提供通过粘弹性溶液的受控凝胶化产生的物理交联水凝胶，其中可操作性保持预定时间。 另一方面，本发明提供了用于修复椎间盘或关节连接的试剂盒，其包括形成乙烯基聚合物水凝胶的组分和分配器。

公开(公告)号：US20060228401A1

公开(公告)日：2006-10-12

申请号：US11419918

申请日：2006-05-23

申请人： Gavin BRAITHWAITE ,  Jeffrey Ruberti

发明人： Gavin BRAITHWAITE ,  Jeffrey Ruberti

IPC分类号： A61K9/70 ,  A61K38/39

CPC分类号： A61L27/24 ,  A61L27/38 ,  A61L27/50 ,  A61L2400/18 ,  B29C41/045 ,  B29C41/22 ,  B29C41/36 ,  B29C41/52 ,  B29C48/022 ,  B29C48/08 ,  B29C67/0003 ,  B29C67/24 ,  B29C2037/90 ,  B29K2089/00 ,  B29K2995/005 ,  C08L89/06 ,  D01D5/18 ,  D01D5/38 ,  D01F4/00

摘要： This invention includes a method of producing a thin, oriented layer of polymer material. The material is preferably produced by the method of introducing a shearing flow to a free surface in a predominantly monomeric solution of the self-assembling polymer sub-units, and inducing polymerization or growth of the monomer while in this shearing flow. The system for forming the oriented layer of material provides relative movement between a delivery system and the substrate on or over which the material is deposited. The rate of flow of the material from the delivery system and the relative velocity between the deposition surface and the material as it is developed to the surface are controlled to properly orient the material and desired thickness. These rates can be adjusted to vary the properties of the film in a controlled manner. Preferred embodiments include either angular or linear relative movement between the delivery system and the substrate.

摘要翻译： 本发明包括一种制备薄的取向层的聚合物材料的方法。 该材料优选通过将剪切流引入自组装聚合物子单元的主要单体溶液中的自由表面并在该剪切流中引发单体的聚合或生长的方法来制备。 用于形成材料的定向层的系统提供在材料沉积物上或其上的输送系统和基底之间的相对运动。 控制来自输送系统的材料的流动速率以及沉积表面和材料在其被发展到表面时的相对速度，以适当地定向材料和期望的厚度。 可以调整这些速率以便以受控的方式改变胶片的性质。 优选实施例包括在输送系统和基底之间的角度或线性的相对运动。