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    NUCLEIC ACID COMPLEXITY REDUCTION
    1.
    发明申请
    NUCLEIC ACID COMPLEXITY REDUCTION 审中-公开
    核酸复合物减少

    公开(公告)号：US20140243232A1

    公开(公告)日：2014-08-28

    申请号：US14232572

    申请日：2012-07-13

    申请人： Gavin Meredith ,  Christopher Clouser ,  Tanya Sokolsky ,  Kimberly Mather ,  Kevin McKernan ,  Marie Callahan ,  Gary Bee

    发明人： Gavin Meredith ,  Christopher Clouser ,  Tanya Sokolsky ,  Kimberly Mather ,  Kevin McKernan ,  Marie Callahan ,  Gary Bee

    IPC分类号： C12Q1/68 ,  C07H21/00

    CPC分类号： C12Q1/6874 ,  C12Q1/6832 ,  C12Q2525/191 ,  C12Q2537/159 ,  C12Q2537/163 ,  C12Q2563/131

    摘要： In some embodiments, the present teachings provide compositions, systems, methods and kits for reducing the complexity of nucleotide sequences in a nucleic acid sample comprising the steps: hybridizing a plurality of polynucleotide constructs to at least one blocker oligonucleotide and to at least one capture oligonucleotide, wherein the plurality of polynucleotide constructs include a plurality of polynucleotides each joined to at least one nucleic acid adaptor, wherein the at least one nucleic acid adaptor can hybridize to the at least one blocker oligonucleotide, and wherein the at least one capture oligonucleotide can hybridize to at least a portion of target polynucleotides that are a sub-population of the plurality of polynucleotides, so as to produce a capture duplex.

    摘要翻译： 在一些实施方案中，本教导提供了用于降低核酸样品中核苷酸序列的复杂性的组合物，系统，方法和试剂盒，其包括以下步骤：将多个多核苷酸构建体与至少一个阻断寡核苷酸和至少一个捕获寡核苷酸杂交 其中所述多个多核苷酸构建体包括多个多核苷酸，其各自与至少一个核酸衔接子连接，其中所述至少一个核酸衔接子可以与所述至少一个阻断寡核苷酸杂交，并且其中所述至少一个捕获寡核苷酸可以杂交 至少一部分作为多个多核苷酸的亚群的靶多核苷酸，以产生捕获双链体。

    Hybridization assay probes and methods for detecting the presence of neisseria meningitiidis subtypes A, C and L in a sample
    2.
    发明授权
    Hybridization assay probes and methods for detecting the presence of neisseria meningitiidis subtypes A, C and L in a sample 有权
    杂交测定探针和用于检测样本中脑膜炎奈瑟菌亚型A，C和L的存在的方法

    公开(公告)号：US06541201B1

    公开(公告)日：2003-04-01

    申请号：US09394175

    申请日：1999-09-13

    申请人： Yeasing Yang ,  Gary Bee ,  Sherrol McDonough

    发明人： Yeasing Yang ,  Gary Bee ,  Sherrol McDonough

    IPC分类号： C12Q168

    CPC分类号： C12Q1/689

    摘要： The present invention discloses hybridization assay probes, amplification primers, nucleic acid compositions and methods useful for detecting Neisseria nucleic acids. Hybridization assay probes and amplification primers that selectively detect Neisseria meningitidis and distinguish those Neisseria meningitidis from Neisseria gonorrohoeae are disclosed. Other hybridization probes selectively detect Neisseria gonorrohoeae and not Neisseria meningitidis are also described.

    摘要翻译： 本发明公开了杂交测定探针，扩增引物，核酸组合物和用于检测奈瑟氏球菌核酸的方法。 公开了选择性检测脑膜炎奈瑟菌并将脑膜炎奈瑟氏球菌与奈瑟氏球菌分离的杂交测定探针和扩增引物。 还描述了其他杂交探针选择性检测淋病奈瑟菌，而不是脑膜炎奈瑟氏球菌。

    Nucleic acid probes and amplification oligonucleotides for Neisseria species
    4.
    发明授权
    Nucleic acid probes and amplification oligonucleotides for Neisseria species 失效
    核酸探针和奈瑟菌属种的扩增寡核苷酸

    公开(公告)号：US6100027A

    公开(公告)日：2000-08-08

    申请号：US962369

    申请日：1997-10-31

    申请人： Yeasing Yang ,  Gary Bee ,  Sherrol McDonough

    发明人： Yeasing Yang ,  Gary Bee ,  Sherrol McDonough

    IPC分类号： C12Q1/68 ,  C07H21/02 ,  C07H21/04 ,  C12P19/34

    CPC分类号： C12Q1/689

    摘要： The present invention discloses hybridization assay probes, amplification primers, nucleic acid compositions and methods useful for detecting Neisseria nucleic acids. Hybridization assay probes and amplification primers that selectively detect Neisseria meningitidis and distinguish those Neisseria meningitidis from Neisseria gonorrohoeae are disclosed. Other hybridization probes selectively detect Neisseria gonorrohoeae and not Neisseria meningitidis are also described.

    摘要翻译： 本发明公开了杂交测定探针，扩增引物，核酸组合物和用于检测奈瑟氏球菌核酸的方法。 公开了选择性检测脑膜炎奈瑟菌并将脑膜炎奈瑟氏球菌与奈瑟氏球菌分离的杂交测定探针和扩增引物。 还描述了其他杂交探针选择性检测淋病奈瑟菌，而不是脑膜炎奈瑟氏球菌。