公开(公告)号：US20230270788A1

公开(公告)日：2023-08-31

申请号：US17767453

申请日：2020-10-08

申请人： GENECHEM INC. ,  UNIVERSITY INDUSTRY FOUNDATION, YONSEI UNIVERSITY WONJU CAMPUS ,  INDUSTRY-ACADEMIC COOPERATION FOUNDATION,YONSEI UNIVERSITY

发明人： Sung Hoon KIM ,  Ah Reum BAEK ,  Sung Rae CHO ,  Jin Suk WOO ,  Li La KIM ,  Dae Hee KIM

IPC分类号： A61K35/28 ,  A61K35/545 ,  C12N5/0775

CPC分类号： A61K35/28 ,  A61K35/545 ,  C12N5/0662 ,  C12N2500/34 ,  C12N2500/38 ,  C12N2501/11 ,  C12N2501/155 ,  C12N2501/12 ,  C12N2501/237

摘要： The present application pertains to a sialyloligosaccharide for augmenting the stemness of stem cells and a use thereof and provides a composition for augmenting stemness of stem cells, a method of culturing stem cells in a medium containing a sialyloligosaccharide, a method of augmenting stemness of stem cells, a stem cell with augmented stemness, obtained by the method, and a cell therapy composition including the stem cells as an active ingredient. The composition or the method according to one or more embodiments may suppress the aging of stem cells and may maintain and augment stemness.

公开(公告)号：US20220089631A1

公开(公告)日：2022-03-24

申请号：US17270184

申请日：2019-08-22

申请人： Genechem Inc.

发明人： Jin Suk WOO ,  Dae Hee KIM ,  Sang Mi LEE ,  Sang Eun YOO ,  Won Min SEO ,  Ji Young YANG ,  Li La KIM

IPC分类号： C07H17/04 ,  C07H15/18 ,  A61K9/00 ,  A61K9/48 ,  A61K9/20 ,  A61P31/16

摘要： The present invention relates to a use of a compound comprising a multivalent sialyloligosaccharide residue, an optical isomer thereof or a pharmaceutically acceptable salt thereof, and a composition comprising the same as an active ingredient for preventing or treating viral infectious diseases. The present invention shows high hemagglutination inhibitory activity and virus neutralizing activity so as to have excellent antiviral activity, thereby being effectively usable as a composition for preventing or treating viral infectious diseases.