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公开(公告)号:US09937224B2
公开(公告)日:2018-04-10
申请号:US14822711
申请日:2015-08-10
Applicant: Genentech, Inc.
Inventor: Ryan J. Watts , Mark Chen , Joseph Wesley Lewcock , Christine Pozniak , Arundhati Sengupta-Ghosh
IPC: A61K39/395 , A61K33/14 , A61K31/40 , A61K38/12 , A61K31/7088 , A61K31/711 , C12N15/113 , A61K31/7105 , A61K31/277 , A61K31/35 , A61K31/4015 , A61K31/416 , A61K31/4439 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K38/05 , A61K38/18 , C07K16/22 , G01N33/50 , A61K31/12 , A61K31/165 , A61K31/352 , A61K31/4184 , A61K31/426 , A61K31/433 , A61K31/45 , A61K31/496 , A61K31/505 , A61K31/517 , A61K31/519 , A61K31/713 , C07K16/40
CPC classification number: A61K38/12 , A61K31/12 , A61K31/165 , A61K31/277 , A61K31/35 , A61K31/352 , A61K31/40 , A61K31/4015 , A61K31/416 , A61K31/4184 , A61K31/426 , A61K31/433 , A61K31/4439 , A61K31/45 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/7088 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K33/14 , A61K38/05 , A61K38/185 , C07K16/22 , C07K16/40 , C07K2317/76 , C12N15/113 , C12N15/1137 , C12N2310/14 , C12N2320/30 , G01N33/5058
Abstract: The invention relates generally to treatment of neurological disorders and nervous system injuries. The invention specifically provides methods of using modulators of particular target proteins to modulate degeneration of neurons or portions thereof, such as axons.