公开(公告)号：US20230416401A1

公开(公告)日：2023-12-28

申请号：US18166994

申请日：2023-02-09

Applicant: Genentech, Inc.

Inventor： Reed J. HARRIS ,  Paul MOTCHNIK

IPC: C07K16/32 ,  C07K16/06 ,  C07K1/18 ,  C07K16/28

CPC classification number: C07K16/32 ,  C07K16/065 ,  C07K1/18 ,  G01N27/447 ,  C07K16/2863 ,  C07K2317/41 ,  C07K16/2896

Abstract: A composition comprising a main species HER2 antibody that binds to domain II of HER2 and acidic variants thereof is described. Pharmaceutical formulations comprising the composition, and therapeutic uses for the composition are also disclosed.

公开(公告)号：US20240262932A1

公开(公告)日：2024-08-08

申请号：US18640824

申请日：2024-04-19

Applicant: Genentech, Inc.

Inventor： Reed J. HARRIS ,  Paul A. MOTCHNIK

IPC: C07K16/32 ,  A61K39/00 ,  C07K1/18 ,  C07K16/06 ,  C07K16/28 ,  G01N27/447 ,  G01N30/02

CPC classification number: C07K16/32 ,  C07K1/18 ,  C07K16/065 ,  C07K16/2863 ,  C07K16/2896 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/76 ,  G01N27/447 ,  G01N30/02 ,  G01N2030/027

Abstract: A composition comprising a main species HER2 antibody that binds to domain II of HER2 and acidic variants thereof is described. Pharmaceutical formulations comprising the composition, and therapeutic uses for the composition are also disclosed.

公开(公告)号：US20220363780A1

公开(公告)日：2022-11-17

申请号：US17815535

申请日：2022-07-27

Applicant: Genentech, Inc.

Inventor： Reed J. HARRIS ,  Paul A. MOTCHNICK

IPC: C07K16/32 ,  C07K16/06 ,  C07K1/18 ,  C07K16/28

Abstract: A composition comprising a main species HER2 antibody that binds to domain II of HER2 and acidic variants thereof is described. Pharmaceutical formulations comprising the composition, and therapeutic uses for the composition are also disclosed.