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公开(公告)号：US20180016325A1
公开(公告)日：2018-01-18
申请号：US15718876
申请日：2017-09-28
申请人： Genentech, Inc.
发明人： Eric J. Brown , Martine Darwish , John Flygare , Wouter Hazenbos , Byoung Chul Lee , Sophie M. Lehar , Sanjeev Mariathasan , John Hiroshi Morisaki , Thomas H. Pillow , Leanna Staben , Richard Vandlen , Klaus Koefoed , Magnus Strandh , Peter S. Andersen
IPC分类号： C07K16/12 , A61K45/06 , A61K39/40 , A61K31/4025 , A61K31/5386
CPC分类号： C07K16/1271 , A61K31/4025 , A61K31/5386 , A61K39/40 , A61K45/06 , A61K47/6809 , A61K47/6835 , C07K2317/21 , C07K2317/522 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/624 , C07K2317/92
摘要： The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same.
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公开(公告)号：US20160074529A1
公开(公告)日：2016-03-17
申请号：US14945716
申请日：2015-11-19
申请人： GENENTECH, INC.
发明人： Eric J. Brown , John Flygare , Wouter Hazenbos , Sophie M. Lehar , Sanjeev Mariathasan , John Hiroshi Morisaki , Thomas H. Pillow , Leanna Staben , Richard Vandlen , Klaus Koefoed , Magnus Strandh , Peter S. Andersen
IPC分类号： A61K47/48 , A61K31/7048 , A61K31/4709 , A61K38/12 , A61K31/4375 , A61K31/4436 , A61K31/7056 , A61K31/439
CPC分类号： A61K47/6849 , A61K31/395 , A61K31/4375 , A61K31/439 , A61K31/4436 , A61K31/4709 , A61K31/7048 , A61K31/7056 , A61K38/12 , A61K47/6801 , A61K47/6803 , A61K47/6809 , A61K47/6835 , A61K47/6851 , C07K16/1271 , C07K2317/21 , C07K2317/522 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/624 , C07K2317/92
摘要： The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same.
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公开(公告)号：US20180125995A1
公开(公告)日：2018-05-10
申请号：US15612193
申请日：2017-06-02
申请人： Genentech, Inc.
发明人： Eric Brown , Wouter Hazenbos , Isidro Hotzel , Kimberly Kajihara , Sophie M. Lehar , Sanjeev Mariathasan , Thomas Pillow , Leanna Staben , Vishal Verma , Binqing Wei , Yi Xia , Min Xu
IPC分类号： A61K47/68 , C07K16/12 , A61K31/5383 , A61K45/06 , A61P31/04
CPC分类号： A61K47/6803 , A61K31/5383 , A61K45/06 , A61K47/6835 , A61K47/6889 , A61P31/04 , C07K16/1271 , C07K2317/21
摘要： The invention provides rF1 antibody antibiotic conjugates and methods of using same.
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公开(公告)号：US09920123B2
公开(公告)日：2018-03-20
申请号：US15335278
申请日：2016-10-26
申请人： Genentech, Inc.
发明人： Bryan Irving , Henry Chiu , Heather Maecker , Sanjeev Mariathasan , Sophie M. Lehar , Yan Wu , Jeanne Cheung
IPC分类号： A61K39/00 , C07K16/28 , C07K16/30 , A61K31/7068 , A61K39/395 , A61K45/06 , C07K16/10 , C07K16/22
CPC分类号： C07K16/2827 , A61K31/7068 , A61K39/00 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/1063 , C07K16/22 , C07K16/28 , C07K16/30 , C07K16/3046 , C07K2317/14 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2317/92 , Y02A50/41 , Y02A50/412 , Y02A50/423 , Y02A50/492 , A61K2300/00
摘要： The present application relates to anti-PD-L1 antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection (e.g., acute and chronic) and tumor immunity.
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公开(公告)号：US09884126B2
公开(公告)日：2018-02-06
申请号：US14284619
申请日：2014-05-22
申请人： Genentech, Inc.
发明人： Eric J. Brown , John Flygare , Wouter Hazenbos , Sophie M. Lehar , Sanjeev Mariathasan , John Hiroshi Morisaki , Thomas H. Pillow , Leanna Staben , Richard Vandlen , Klaus Koefoed , Magnus Strandh , Peter S. Andersen
IPC分类号： A61K47/48 , C07K16/12 , A61K31/395 , A61K31/4375 , A61K31/439 , A61K31/4436 , A61K31/4709 , A61K31/7048 , A61K31/7056 , A61K38/12
CPC分类号： A61K47/6849 , A61K31/395 , A61K31/4375 , A61K31/439 , A61K31/4436 , A61K31/4709 , A61K31/7048 , A61K31/7056 , A61K38/12 , A61K47/6801 , A61K47/6803 , A61K47/6809 , A61K47/6835 , A61K47/6851 , C07K16/1271 , C07K2317/21 , C07K2317/522 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/624 , C07K2317/92
摘要： The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same.
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公开(公告)号：US20180021450A1
公开(公告)日：2018-01-25
申请号：US15611985
申请日：2017-06-02
申请人： Genentech, Inc.
发明人： Eric Brown , Wouter Hazenbos , Isidro Hotzel , Kimberly Kajihara , Sophie M. Lehar , Sanjeev Mariathasan , Thomas Pillow , Leanna Staben , Vishal Verma , Binqing Wei , Min Xu
IPC分类号： A61K47/68 , A61K31/4468 , A61K39/40 , A61K31/496
CPC分类号： A61K47/6809 , A61K31/4468 , A61K31/496 , A61K39/40 , A61K47/6803 , A61K47/6835 , A61K47/6889
摘要： The invention provides anti-Staphylococcus aureus antibody rifamycin antibiotic conjugates and methods of using same.
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公开(公告)号：US20180085470A1
公开(公告)日：2018-03-29
申请号：US15834740
申请日：2017-12-07
申请人： Genentech, Inc.
发明人： Eric J. Brown , John Flygare , Wouter Hazenbos , Sophie M. Lehar , Sanjeev Mariathasan , John Hiroshi Morisaki , Thomas H. Pillow , Leanna Staben , Richard Vandlen , Klaus Koefoed , Magnus Strandh , Peter S. Andersen
IPC分类号： A61K31/7056 , A61K31/395 , A61K31/4375 , A61K31/439 , A61K31/4436 , C07K16/12 , A61K38/12 , A61K31/7048 , A61K31/4709
CPC分类号： A61K47/6849 , A61K31/395 , A61K31/4375 , A61K31/439 , A61K31/4436 , A61K31/4709 , A61K31/7048 , A61K31/7056 , A61K38/12 , A61K47/6801 , A61K47/6803 , A61K47/6809 , A61K47/6835 , A61K47/6851 , C07K16/1271 , C07K2317/21 , C07K2317/522 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/624 , C07K2317/92
摘要： The invention provides anti-wall teichoic acid antibodies, antibiotic-linker intermediates, and antibody-antibiotic conjugate compound, and methods of making and using the same.
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公开(公告)号：US09895450B2
公开(公告)日：2018-02-20
申请号：US14945716
申请日：2015-11-19
申请人： Genentech, Inc.
发明人： Eric J. Brown , John Flygare , Wouter Hazenbos , Sophie M. Lehar , Sanjeev Mariathasan , John Hiroshi Morisaki , Thomas H. Pillow , Leanna Staben , Richard Vandlen , Klaus Koefoed , Magnus Strandh , Peter S. Andersen
IPC分类号： A61K39/395 , A61K47/48 , C07K16/12 , A61K31/395 , A61K31/4375 , A61K31/439 , A61K31/4436 , A61K31/4709 , A61K31/7048 , A61K31/7056 , A61K38/12
CPC分类号： A61K47/6849 , A61K31/395 , A61K31/4375 , A61K31/439 , A61K31/4436 , A61K31/4709 , A61K31/7048 , A61K31/7056 , A61K38/12 , A61K47/6801 , A61K47/6803 , A61K47/6809 , A61K47/6835 , A61K47/6851 , C07K16/1271 , C07K2317/21 , C07K2317/522 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/624 , C07K2317/92
摘要： The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same.
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公开(公告)号：US09803002B2
公开(公告)日：2017-10-31
申请号：US14292289
申请日：2014-05-30
申请人： Genentech, Inc.
发明人： Eric J. Brown , Martine Darwish , John Flygare , Wouter Hazenbos , Byoung Chul Lee , Sophie M. Lehar , Sanjeev Mariathasan , John Hiroshi Morisaki , Thomas H. Pillow , Leanna Staben , Richard Vandlen , Klaus Koefoed , Magnus Strandh , Peter S. Andersen
IPC分类号： A61K39/40 , C07K16/12 , A61K31/5386 , A61K45/06 , A61K31/4025 , A61K47/68
CPC分类号： C07K16/1271 , A61K31/4025 , A61K31/5386 , A61K39/40 , A61K45/06 , A61K47/6809 , A61K47/6835 , C07K2317/21 , C07K2317/522 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/624 , C07K2317/92
摘要： The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same.
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公开(公告)号：US20140356376A1
公开(公告)日：2014-12-04
申请号：US14292289
申请日：2014-05-30
申请人： Genentech, Inc.
发明人： Eric J. Brown , Martine Darwish , John Flygare , Wouter Hazenbos , Byoung Chul Lee , Sophie M. Lehar , Sanjeev Mariathasan , John Hiroshi Morisaki , Thomas H. Pillow , Leanna Staben , Richard Vandlen , Klaus Koefoed , Magnus Strandh , Peter S. Andersen
IPC分类号： C07K16/12 , A61K31/4025 , A61K47/48 , A61K45/06 , A61K39/40 , A61K31/5386
CPC分类号： C07K16/1271 , A61K31/4025 , A61K31/5386 , A61K39/40 , A61K45/06 , A61K47/6809 , A61K47/6835 , C07K2317/21 , C07K2317/522 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/624 , C07K2317/92
摘要： The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same.
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