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公开(公告)号：US10481222B2
公开(公告)日：2019-11-19
申请号：US15658123
申请日：2017-07-24
Applicant: General Electric Company
Inventor： Ernst Wolfgang Stautner , Jan Henrik Ardenkjaer-Larsen , Patrick L. Padgett , Jonathan Alan Murray , Rui Chen , James Richard Trigger , Arnaud Comment , Albert Po-Fu Chen
Abstract: A cooling system is provided. The cooling system is associated with a dynamic nuclear polarization system and configured to cool a sample to a temperature suitable for dynamic nuclear polarization to be carried out on the sample while the sample is in the cooling system. The cooling system includes a cryogenic chamber that includes a cryogenic fluid. The cooling system also includes a removable sample sleeve insertable within a portion of the cryogenic chamber. The removable sample sleeve is configured to define a sample path for the sample within the cryogenic chamber that is isolated from other parts of the cooling system.
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公开(公告)号：US20190025387A1
公开(公告)日：2019-01-24
申请号：US15658123
申请日：2017-07-24
Applicant: General Electric Company
Inventor： Ernst Wolfang Stautner , Jan Henrik Ardenkjaer-Larsen , Patrick L. Padgett , Jonathan Alan Murray , Rui Chen , James Richard Trigger , Arnaud Comment , Albert Po-Fu Chen
CPC classification number: G01R33/31 , F25B19/005 , F25D19/006 , F25D21/002 , F25D29/001 , G01N1/42 , G01R33/282
Abstract: A cooling system is provided. The cooling system is associated with a dynamic nuclear polarization system and configured to cool a sample to a temperature suitable for dynamic nuclear polarization to be carried out on the sample while the sample is in the cooling system. The cooling system includes a cryogenic chamber that includes a cryogenic fluid. The cooling system also includes a removable sample sleeve insertable within a portion of the cryogenic chamber. The removable sample sleeve is configured to define a sample path for the sample within the cryogenic chamber that is isolated from other parts of the cooling system.
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公开(公告)号：US09283317B2
公开(公告)日：2016-03-15
申请号：US13841945
申请日：2013-03-15
Applicant: General Electric Company
Inventor： Angus Zoen Lau , Albert Po-Fu Chen , Charles H. Cunningham
CPC classification number: A61M5/007 , A61B5/055 , G01R33/5601
Abstract: Disclosed embodiments for assessing brown adipose tissue use imaging of metabolic contrast agents. For example, activated brown adipose tissue may be assessed by evaluating a difference in production of the hyperpolarized 13C metabolic contrast agent from a pre-polarized 13C metabolic contrast agent precursor before and after exposure of the subject to an activating event or agent. In one embodiment, the subject is given a dose of norepinephrine, and the production of the hyperpolarized 13C metabolic contrast agent before and after the dose is assessed.
Abstract translation: 用于评估棕色脂肪组织的公开的实施方案使用代谢造影剂的成像。 例如，可以通过在受试者暴露于激活事件或试剂之前和之后评估来自预极化的13C代谢造影剂前体的超极化13C代谢造影剂的产生差异来评估活化的棕色脂肪组织。 在一个实施方案中，给予受试者一定剂量的去甲肾上腺素，并且评估在剂量之前和之后产生超极化13C代谢造影剂。
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公开(公告)号：US20140275969A1
公开(公告)日：2014-09-18
申请号：US13841945
申请日：2013-03-15
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Angus Zoen Lau , Albert Po-Fu Chen , Charles H. Cunningham
CPC classification number: A61M5/007 , A61B5/055 , G01R33/5601
Abstract: Disclosed embodiments for assessing brown adipose tissue use imaging of metabolic contrast agents. For example, activated brown adipose tissue may be assessed by evaluating a difference in production of the hyperpolarized 13C metabolic contrast agent from a pre-polarized 13C metabolic contrast agent precursor before and after exposure of the subject to an activating event or agent. In one embodiment, the subject is given a dose of norepinephrine, and the production of the hyperpolarized 13C metabolic contrast agent before and after the dose is assessed.
Abstract translation: 用于评估棕色脂肪组织的公开的实施方案使用代谢造影剂的成像。 例如，可以通过在受试者暴露于激活事件或试剂之前和之后评估来自预极化的13C代谢造影剂前体的超极化13C代谢造影剂的产生差异来评估活化的棕色脂肪组织。 在一个实施方案中，给予受试者一定剂量的去甲肾上腺素，并且评估在剂量之前和之后产生超极化13C代谢造影剂。
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