公开(公告)号：US20210071207A1

公开(公告)日：2021-03-11

申请号：US16889211

申请日：2020-06-01

申请人： Genomatica, Inc.

发明人： Andreas W. Schirmer ,  Noah HELMAN ,  Haibo Wang ,  Zhihao Hu ,  Vikranth Arlagadda ,  Alma Itzel RAMOS-SOLIS ,  Elizabeth Clarke

IPC分类号： C12P7/18 ,  C12N9/00 ,  C12N9/16 ,  C12N15/52

摘要： The disclosure relates to fatty diols and recombinant microorganisms for producing them. More particularly, the disclosure relates to recombinant microorganisms engineered to produce fatty diols via fermentation. Further encompassed is a process that uses the microorganisms to produce fatty diols from a simple carbon source.

公开(公告)号：US11359216B2

公开(公告)日：2022-06-14

申请号：US16889211

申请日：2020-06-01

申请人： Genomatica, Inc.

发明人： Andreas W. Schirmer ,  Noah Helman ,  Haibo Wang ,  Zhihao Hu ,  Vikranth Arlagadda ,  Alma Itzel Ramos-Solis ,  Elizabeth Clarke

IPC分类号： C12P7/18 ,  C12N9/00 ,  C12N9/16 ,  C12N15/52

摘要： The disclosure relates to fatty diols and recombinant microorganisms for producing them. More particularly, the disclosure relates to recombinant microorganisms engineered to produce fatty diols via fermentation. Further encompassed is a process that uses the microorganisms to produce fatty diols from a simple carbon source.

公开(公告)号：US11021695B2

公开(公告)日：2021-06-01

申请号：US15958229

申请日：2018-04-20

申请人： GENOMATICA, INC.

发明人： Louis Hom ,  Na Trinh ,  Murtaza Alibhai ,  Zhihao Hu ,  Eli Groban ,  Vikranth Arlagadda ,  Elizabeth Clarke

IPC分类号： C12N9/16 ,  C12N15/00 ,  C12N9/18 ,  C12N15/63 ,  C10L1/02 ,  C07H21/04 ,  C12P21/06

摘要： The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of thioesterase enzymes. In particular, the present invention provides mutant thioesterase enzymes that have altered properties, for example, altered substrate specificity, altered activity, altered selectivity, and/or altered proportional yields in the product mixtures. The present invention also provides polynucleotides encoding such mutant thioesterase enzymes, and vectors and host cells comprising such polynucleotides. The invention further provides for novel uses of thioesterases in the production of various fatty acid derivatives, which are useful as, or as components of, industrial chemicals and fuels.