公开(公告)号：US20250101392A1

公开(公告)日：2025-03-27

申请号：US18662446

申请日：2024-05-13

Applicant: Genomatica, Inc.

Inventor： Andrew M. SHUMAKER ,  Bernardo M.T. DA COSTA ,  Kevin HOLDEN ,  Louis G. HOM ,  Tarah S. BARON ,  Noah HELMAN

IPC: C12N9/18 ,  C12N9/10 ,  C12P7/6436

Abstract: The disclosure relates to enzyme variants with improved ester synthase properties for the production of fatty acid esters. Further contemplated are recombinant host cells that express such variants, cell cultures comprising the recombinant host cells and fatty acid ester compositions produced by such recombinant host cells.

公开(公告)号：US20210348173A1

公开(公告)日：2021-11-11

申请号：US17335812

申请日：2021-06-01

Applicant: Genomatica, Inc.

Inventor： Derek L. GREENFIELD ,  Andreas W. SCHIRMER ,  Elizabeth J. CLARKE ,  Eli S. GROBAN ,  Bernardo M. DA COSTA ,  Zhihao HU ,  Kevin HOLDEN ,  Noah HELMAN

IPC: C12N15/70 ,  C12N9/04 ,  C12N9/02 ,  C12N9/10 ,  C12N9/12 ,  C12N9/88 ,  C12N9/90 ,  C12N9/00 ,  C12P7/04 ,  C12P7/64

Abstract: The disclosure relates to recombinant host cells including strain modifications effective to improve titer, yield and/or productivity of fatty acid derivatives. The disclosure further relates to cell cultures including the recombinant host cells for the fermentative production of fatty acid derivatives and compositions thereof.

公开(公告)号：US20250101471A1

公开(公告)日：2025-03-27

申请号：US18800482

申请日：2024-08-12

Applicant: Genomatica, Inc.

Inventor： Andreas W. SCHIRMER ,  Noah HELMAN ,  Haibo WANG ,  Zhihao HU ,  Vikranth ARLAGADDA ,  Alma Itzel RAMOS-SOLIS ,  Elizabeth J. CLARKE

IPC: C12P7/18 ,  C12N9/00 ,  C12N9/16 ,  C12N15/52

Abstract: The disclosure relates to fatty diols and recombinant microorganisms for producing them. More particularly, the disclosure relates to recombinant microorganisms engineered to produce fatty diols via fermentation. Further encompassed is a process that uses the microorganisms to produce fatty diols from a simple carbon source.

公开(公告)号：US20220267813A1

公开(公告)日：2022-08-25

申请号：US17732799

申请日：2022-04-29

Applicant: Genomatica, Inc.

Inventor： Andreas W. SCHIRMER ,  Noah HELMAN ,  Haibo WANG ,  Zhihao HU ,  Vikranth ARLAGADDA ,  Alma Itzel RAMOS-SOLIS ,  Elizabeth CLARKE

IPC: C12P7/18 ,  C12N9/00 ,  C12N9/16 ,  C12N15/52

Abstract: The disclosure relates to fatty diols and recombinant microorganisms for producing them. More particularly, the disclosure relates to recombinant microorganisms engineered to produce fatty diols via fermentation. Further encompassed is a process that uses the microorganisms to produce fatty diols from a simple carbon source.

公开(公告)号：US20210309979A1

公开(公告)日：2021-10-07

申请号：US17116817

申请日：2020-12-09

Applicant: Genomatica, Inc.

Inventor： Andrew M. SHUMAKER ,  Bernardo M. DA COSTA ,  Kevin HOLDEN ,  Louis G. HOM ,  Tarah S. BARON ,  Noah HELMAN

IPC: C12N9/18 ,  C12N9/10 ,  C12P7/64

Abstract: The disclosure relates to enzyme variants with improved ester synthase properties for the production of fatty acid esters. Further contemplated are recombinant host cells that express such variants, cell cultures comprising the recombinant host cells and fatty acid ester compositions produced by such recombinant host cells.

公开(公告)号：US20210071207A1

公开(公告)日：2021-03-11

申请号：US16889211

申请日：2020-06-01

Applicant: Genomatica, Inc.

Inventor： Andreas W. Schirmer ,  Noah HELMAN ,  Haibo Wang ,  Zhihao Hu ,  Vikranth Arlagadda ,  Alma Itzel RAMOS-SOLIS ,  Elizabeth Clarke

IPC: C12P7/18 ,  C12N9/00 ,  C12N9/16 ,  C12N15/52

Abstract: The disclosure relates to fatty diols and recombinant microorganisms for producing them. More particularly, the disclosure relates to recombinant microorganisms engineered to produce fatty diols via fermentation. Further encompassed is a process that uses the microorganisms to produce fatty diols from a simple carbon source.