公开(公告)号：US11034937B2

公开(公告)日：2021-06-15

申请号：US16414550

申请日：2019-05-16

Applicant: Genomatica, Inc.

Inventor： Derek L. Greenfield ,  Elizabeth J. Clarke ,  Eli S. Groban ,  Vikranth Arlagadda ,  Sungwon Lee ,  Xuezhi Li ,  Zhihao Hu ,  Baolong Zhu

IPC: C12P7/04 ,  C12N9/02 ,  C12P7/64

Abstract: The disclosure relates to variant carboxylic acid reductase (CAR) enzymes for the improved production of fatty alcohols in recombinant host cells.

公开(公告)号：US11021695B2

公开(公告)日：2021-06-01

申请号：US15958229

申请日：2018-04-20

Applicant: GENOMATICA, INC.

Inventor： Louis Hom ,  Na Trinh ,  Murtaza Alibhai ,  Zhihao Hu ,  Eli Groban ,  Vikranth Arlagadda ,  Elizabeth Clarke

IPC: C12N9/16 ,  C12N15/00 ,  C12N9/18 ,  C12N15/63 ,  C10L1/02 ,  C07H21/04 ,  C12P21/06

Abstract: The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of thioesterase enzymes. In particular, the present invention provides mutant thioesterase enzymes that have altered properties, for example, altered substrate specificity, altered activity, altered selectivity, and/or altered proportional yields in the product mixtures. The present invention also provides polynucleotides encoding such mutant thioesterase enzymes, and vectors and host cells comprising such polynucleotides. The invention further provides for novel uses of thioesterases in the production of various fatty acid derivatives, which are useful as, or as components of, industrial chemicals and fuels.

公开(公告)号：US11359216B2

公开(公告)日：2022-06-14

申请号：US16889211

申请日：2020-06-01

Applicant: Genomatica, Inc.

Inventor： Andreas W. Schirmer ,  Noah Helman ,  Haibo Wang ,  Zhihao Hu ,  Vikranth Arlagadda ,  Alma Itzel Ramos-Solis ,  Elizabeth Clarke

IPC: C12P7/18 ,  C12N9/00 ,  C12N9/16 ,  C12N15/52

Abstract: The disclosure relates to fatty diols and recombinant microorganisms for producing them. More particularly, the disclosure relates to recombinant microorganisms engineered to produce fatty diols via fermentation. Further encompassed is a process that uses the microorganisms to produce fatty diols from a simple carbon source.

公开(公告)号：US10961553B2

公开(公告)日：2021-03-30

申请号：US15888222

申请日：2018-02-05

Applicant: GENOMATICA, INC.

Inventor： Zhihao Hu ,  Vikranth Arlagadda

IPC: C12P7/64 ,  C12N1/20 ,  C12N9/02 ,  B21D51/26 ,  C12P7/04 ,  A61K38/00 ,  A61K31/045 ,  C12R1/01

Abstract: Methods and compositions, including nucleotide sequences, amino acid sequences, and host cells, for producing fatty alcohols are described.

公开(公告)号：US20210071207A1

公开(公告)日：2021-03-11

申请号：US16889211

申请日：2020-06-01

Applicant: Genomatica, Inc.

Inventor： Andreas W. Schirmer ,  Noah HELMAN ,  Haibo Wang ,  Zhihao Hu ,  Vikranth Arlagadda ,  Alma Itzel RAMOS-SOLIS ,  Elizabeth Clarke

IPC: C12P7/18 ,  C12N9/00 ,  C12N9/16 ,  C12N15/52

Abstract: The disclosure relates to fatty diols and recombinant microorganisms for producing them. More particularly, the disclosure relates to recombinant microorganisms engineered to produce fatty diols via fermentation. Further encompassed is a process that uses the microorganisms to produce fatty diols from a simple carbon source.