公开(公告)号：US20210324431A1

公开(公告)日：2021-10-21

申请号：US17169845

申请日：2021-02-08

Applicant: Genomatica, Inc.

Inventor： Grace J. LEE ,  John HALIBURTON ,  Zhihao HU ,  Andreas W. SCHIRMER ,  Kevin HOLDEN

IPC: C12P7/64 ,  C12N9/10 ,  C12N9/16 ,  C12N9/04 ,  C12N9/18 ,  C12N9/12 ,  C12N9/90 ,  C12N9/88 ,  C07C53/126 ,  C07C57/03

Abstract: Recombinant microbial cells are provided which have been engineered to produce fatty acid derivatives having linear chains containing an odd number of carbon atoms by the fatty acid biosynthetic pathway. Also provided are methods of making odd chain fatty acid derivatives using the recombinant microbial cells, and compositions comprising odd chain fatty acid derivatives produced by such methods.

公开(公告)号：US20210309979A1

公开(公告)日：2021-10-07

申请号：US17116817

申请日：2020-12-09

Applicant: Genomatica, Inc.

Inventor： Andrew M. SHUMAKER ,  Bernardo M. DA COSTA ,  Kevin HOLDEN ,  Louis G. HOM ,  Tarah S. BARON ,  Noah HELMAN

IPC: C12N9/18 ,  C12N9/10 ,  C12P7/64

Abstract: The disclosure relates to enzyme variants with improved ester synthase properties for the production of fatty acid esters. Further contemplated are recombinant host cells that express such variants, cell cultures comprising the recombinant host cells and fatty acid ester compositions produced by such recombinant host cells.

公开(公告)号：US20250101392A1

公开(公告)日：2025-03-27

申请号：US18662446

申请日：2024-05-13

Applicant: Genomatica, Inc.

Inventor： Andrew M. SHUMAKER ,  Bernardo M.T. DA COSTA ,  Kevin HOLDEN ,  Louis G. HOM ,  Tarah S. BARON ,  Noah HELMAN

IPC: C12N9/18 ,  C12N9/10 ,  C12P7/6436

Abstract: The disclosure relates to enzyme variants with improved ester synthase properties for the production of fatty acid esters. Further contemplated are recombinant host cells that express such variants, cell cultures comprising the recombinant host cells and fatty acid ester compositions produced by such recombinant host cells.

公开(公告)号：US20210348173A1

公开(公告)日：2021-11-11

申请号：US17335812

申请日：2021-06-01

Applicant: Genomatica, Inc.

Inventor： Derek L. GREENFIELD ,  Andreas W. SCHIRMER ,  Elizabeth J. CLARKE ,  Eli S. GROBAN ,  Bernardo M. DA COSTA ,  Zhihao HU ,  Kevin HOLDEN ,  Noah HELMAN

IPC: C12N15/70 ,  C12N9/04 ,  C12N9/02 ,  C12N9/10 ,  C12N9/12 ,  C12N9/88 ,  C12N9/90 ,  C12N9/00 ,  C12P7/04 ,  C12P7/64

Abstract: The disclosure relates to recombinant host cells including strain modifications effective to improve titer, yield and/or productivity of fatty acid derivatives. The disclosure further relates to cell cultures including the recombinant host cells for the fermentative production of fatty acid derivatives and compositions thereof.