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16 条记录 (耗时 0.021 秒)

    Atraumatic Occlusion Balloons and Skirts, and Methods of Use Thereof
    7.
    发明申请
    Atraumatic Occlusion Balloons and Skirts, and Methods of Use Thereof 审中-公开
    无创性闭塞气球和裙子及其使用方法

    公开(公告)号：US20130289605A1

    公开(公告)日：2013-10-31

    申请号：US13926619

    申请日：2013-06-25

    申请人： Genzyme Corporation

    发明人： Jean-Marie Vogel ,  William E. Cohn

    IPC分类号： A61B17/12 ,  A61M29/02

    CPC分类号： A61B17/12195 ,  A61B17/08 ,  A61B17/12031 ,  A61B17/1204 ,  A61B17/12045 ,  A61B17/12109 ,  A61B17/12131 ,  A61B17/12136 ,  A61B17/12186 ,  A61B2017/1205 ,  A61M29/02 ,  A61M2025/1052

    摘要： One aspect of the present invention relates to catheters that can be placed in or around bodily conduits to occlude or widen a biological lumen without imparting significant trauma to the lumen. In certain embodiments, the invention particularly relates to the use of a polymer composition which can be made to gel upon insertion into said balloon or skirt. In certain embodiments, the inflating viscous polymer composition is a liquid at room temperature and a gel at mammalian physiological temperature. In certain embodiments, the inflating viscous polymer composition comprises an optionally purified inverse thermosensitive polymer.

    摘要翻译： 本发明的一个方面涉及可以放置在身体管道中或周围的导管，以封闭或加宽生物腔，而不会对内腔产生显着的创伤。 在某些实施方案中，本发明特别涉及聚合物组合物的用途，所述聚合物组合物可以在插入所述气囊或裙部时使其凝胶化。 在某些实施方案中，充气粘性聚合物组合物在室温下为液体，在哺乳动物生理温度下为凝胶。 在某些实施方案中，充气粘性聚合物组合物包含任选纯化的反相热敏聚合物。

    METHODS FOR PREVENTING RETROPULSION OF CONCRETIONS AND FRAGMENTS DURING LITHOTRIPSY
    8.
    发明申请
    METHODS FOR PREVENTING RETROPULSION OF CONCRETIONS AND FRAGMENTS DURING LITHOTRIPSY 有权

    公开(公告)号：US20210353301A1

    公开(公告)日：2021-11-18

    申请号：US17187409

    申请日：2021-02-26

    申请人： Genzyme Corporation

    发明人： Jean-Marie Vogel ,  James A. Wilkie

    IPC分类号： A61B17/12 ,  A61B17/22 ,  A61B18/26 ,  A61M5/00

    摘要： One aspect of the present invention provides a method for the treatment of lithiasis, which mitigates the risk of damage to surrounding body tissue when removing a calculi (e.g., biological concretions, such as urinary, biliary, and pancreatic stones) that obstructs or may otherwise be present within a body's anatomical lumen. In one embodiment, the instant invention provides a method of using a polymer plug to occlude a lumen distal to a calculi, whereby calculi fragments resulting from lithotripsy are prevented from traveling up the lumen. In certain embodiments, a dual lumen catheter is utilized to inject two solutions proximal to the calculi, the mixing of said solutions causing a polymer plug to form.

    Perfusive Organ Hemostasis
    9.
    发明申请
    Perfusive Organ Hemostasis 审中-公开
    呕吐器官止血

    公开(公告)号：US20170043050A1

    公开(公告)日：2017-02-16

    申请号：US15074432

    申请日：2016-03-18

    申请人： Genzyme Corporation ,  Lahey Clinic, Inc.

    发明人： Jean-Marie Vogel ,  James A. Wilkie ,  Peter N. Madras

    IPC分类号： A61L24/04 ,  A61K31/765 ,  A61K45/06 ,  A61L24/00

    CPC分类号： A61L24/046 ,  A61B17/00491 ,  A61B17/11 ,  A61B17/12022 ,  A61B17/12186 ,  A61B17/12195 ,  A61B2017/00252 ,  A61B2017/1107 ,  A61B2017/1135 ,  A61B2017/12004 ,  A61K31/722 ,  A61K31/728 ,  A61K31/765 ,  A61K45/06 ,  A61K51/06 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/06 ,  A61L2300/406 ,  A61L2400/04 ,  C08L71/02

    摘要： Disclosed are compositions, methods and kits to control bleeding through the use of an internal occluder based on polymeric solutions, including use of reverse thermosensitive polymers in nephron-sparing surgeries, which produces a completely bloodless surgical field, allowing speedy resection. In certain embodiments, after a certain amount of time, the flow gradually resumes, with no apparent adverse consequences to the kidney. In certain embodiments, return of blood flow may be accelerated by cooling the kidney. The compositions, methods and kits for perfusive organ hemostasis can also be used to simplify or to enable other organ surgeries or interventional procedures, including liver surgery, prostate surgery, brain surgery, surgery of the uterus, spleen surgery and any surgery on any highly vascularized organs.

    摘要翻译： 公开了通过使用基于聚合物溶液的内部封堵器来控制出血的组合物，方法和试剂盒，包括在肾单位保护手术中使用反向热敏聚合物，其产生完全无血的手术领域，允许快速切除。 在某些实施方案中，在一定量的时间之后，流程逐渐恢复，对肾没有明显的不利后果。 在某些实施方案中，可以通过冷却肾来加速血流量的返回。 用于灌注器官止血的组合物，方法和试剂盒也可用于简化或实现其他器官手术或介入手术，包括肝手术，前列腺手术，脑外科手术，子宫手术，脾脏手术和任何高度血管化的手术 器官。

    Perfusive Organ Hemostasis
    10.
    发明申请
    Perfusive Organ Hemostasis 审中-公开
    呕吐器官止血

    公开(公告)号：US20140205542A1

    公开(公告)日：2014-07-24

    申请号：US14225299

    申请日：2014-03-25

    申请人： Lahey Clinic, Inc. ,  Genzyme Corporation

    发明人： Jean-Marie Vogel ,  James A. Wilkie ,  Peter N. Madras

    IPC分类号： A61K31/765 ,  A61K31/722 ,  A61K31/728 ,  A61K45/06 ,  A61K51/06

    CPC分类号： A61L24/046 ,  A61B17/00491 ,  A61B17/11 ,  A61B17/12022 ,  A61B17/12186 ,  A61B17/12195 ,  A61B2017/00252 ,  A61B2017/1107 ,  A61B2017/1135 ,  A61B2017/12004 ,  A61K31/722 ,  A61K31/728 ,  A61K31/765 ,  A61K45/06 ,  A61K51/06 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/06 ,  A61L2300/406 ,  A61L2400/04 ,  C08L71/02

    摘要： Disclosed are compositions, methods and kits to control bleeding through the use of an internal occluder based on polymeric solutions, including use of reverse thermosensitive polymers in nephron-sparing surgeries, which produces a completely bloodless surgical field, allowing speedy resection. In certain embodiments, after a certain amount of time, the flow gradually resumes, with no apparent adverse consequences to the kidney. In certain embodiments, return of blood flow may be accelerated by cooling the kidney. The compositions, methods and kits for perfusive organ hemostasis can also be used to simplify or to enable other organ surgeries or interventional procedures, including liver surgery, prostate surgery, brain surgery, surgery of the uterus, spleen surgery and any surgery on any highly vascularized organs.

    摘要翻译： 公开了通过使用基于聚合物溶液的内部封堵器来控制出血的组合物，方法和试剂盒，包括在肾单位保护手术中使用反向热敏聚合物，其产生完全无血的手术领域，允许快速切除。 在某些实施方案中，在一定量的时间之后，流程逐渐恢复，对肾没有明显的不利后果。 在某些实施方案中，可以通过冷却肾来加速血流量的返回。 用于灌注器官止血的组合物，方法和试剂盒也可用于简化或实现其他器官手术或介入手术，包括肝手术，前列腺手术，脑外科手术，子宫手术，脾脏手术和任何高度血管化的手术 器官。