公开(公告)号：US06531644B1

公开(公告)日：2003-03-11

申请号：US09488495

申请日：2000-01-20

申请人： Geoffrey Duyk ,  Felix D. Karim ,  Casey Kopczynski ,  Jenny Kopczynski

发明人： Geoffrey Duyk ,  Felix D. Karim ,  Casey Kopczynski ,  Jenny Kopczynski

IPC分类号： G01N3300

CPC分类号： C12N15/8509 ,  A01K67/0339 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2227/30 ,  A01K2227/703 ,  A01K2227/706 ,  A01K2267/0331 ,  A01K2267/0393 ,  C12N2800/30 ,  C12N2800/90 ,  C12N2830/008 ,  C12N2830/75 ,  C12N2830/85 ,  C12N2840/203

摘要： Methods, transformation constructs, and transgenic animals for identifying anti-tumor agents and anti-tumor drug targets are described. The transformation constructs are used to generate transgenic animals that have altered expression of an oncogene or tumor suppressor gene in a target tissue that is dispensable for viability and reproduction. In some embodiments, the altered expression results in abnormal proliferation of the target tissue and normal proliferation in all other tissues. Anti-tumor drug targets can be identified by generating progeny of the transgenic animals that have mutations in various genes. Gene mutations that result in a specific reduction or killing of the target tissue are identified as possible anti-tumor drug targets and are further evaluated. Anti-tumor agents are identified that mimic the effect of the gene mutations that result in specific reduction of the target tissue. Alternatively, anti-tumor agents can be identified by administering various compounds directly to the transgenic animals, or their progeny, and selecting as putative therapeutic agents, compounds that result in target-tissue specific antiproliferation.

公开(公告)号：US07846671B2

公开(公告)日：2010-12-07

申请号：US10352843

申请日：2003-01-27

申请人： Mark Cockett ,  Chandra S. Ramanathan ,  Nicholas J. Lodge ,  Kevin Fitzgerald ,  Terry Stouch ,  Lisa Moore ,  Rachel M. Kindt ,  Jenny Kopczynski ,  Stephen Kohl Doberstein

发明人： Mark Cockett ,  Chandra S. Ramanathan ,  Nicholas J. Lodge ,  Kevin Fitzgerald ,  Terry Stouch ,  Lisa Moore ,  Rachel M. Kindt ,  Jenny Kopczynski ,  Stephen Kohl Doberstein

IPC分类号： G01N33/53

CPC分类号： G01N33/6893 ,  G01N2333/726 ,  G01N2333/916 ,  G01N2500/00 ,  G01N2800/341

摘要： The present invention provides methods that are useful for the treatment or prevention of smooth muscle disorders such as urinary incontinence and compounds that are useful in such methods.

摘要翻译： 本发明提供了可用于治疗或预防平滑肌疾病如尿失禁的方法和可用于这些方法的化合物。

公开(公告)号：US20070065883A1

公开(公告)日：2007-03-22

申请号：US11404725

申请日：2006-04-14

申请人： Mark Cockett ,  Chandra Ramanathan ,  Nicholas Lodge ,  Kevin Fitzgerald ,  Terry Stouch ,  Lisa Moore ,  Rachel Kindt ,  Jenny Kopczynski ,  Stephen Doberstein

发明人： Mark Cockett ,  Chandra Ramanathan ,  Nicholas Lodge ,  Kevin Fitzgerald ,  Terry Stouch ,  Lisa Moore ,  Rachel Kindt ,  Jenny Kopczynski ,  Stephen Doberstein

IPC分类号： C40B30/06 ,  C40B40/10 ,  G01N33/53 ,  G01N33/567

CPC分类号： G01N33/6893 ,  G01N2333/726 ,  G01N2333/916 ,  G01N2500/00 ,  G01N2800/341

摘要： The present invention provides methods that are useful for the treatment or prevention of smooth muscle disorders such as urinary incontinence and compounds that are useful in such methods.

摘要翻译： 本发明提供了可用于治疗或预防平滑肌疾病如尿失禁的方法和可用于这些方法的化合物。