公开(公告)号：US08835183B2

公开(公告)日：2014-09-16

申请号：US12350090

申请日：2009-01-07

申请人： George Bashirians ,  Deborah Byrne ,  Sarah Groulx ,  Sharon Jackson ,  Heather Lane-Brown ,  Banumathi Sankaran ,  Edward Scalice ,  Karen Yang ,  Jian Zheng

发明人： George Bashirians ,  Deborah Byrne ,  Sarah Groulx ,  Sharon Jackson ,  Heather Lane-Brown ,  Banumathi Sankaran ,  Edward Scalice ,  Karen Yang ,  Jian Zheng

IPC分类号： G01N33/543 ,  G01N33/68 ,  G01N33/566

CPC分类号： G01N33/689 ,  G01N33/543 ,  G01N33/566 ,  G01N33/6872 ,  G01N2333/475 ,  G01N2333/515 ,  G01N2333/71 ,  G01N2333/91205 ,  G01N2800/368 ,  G01N2800/50 ,  G01N2800/56

摘要： Methods for determining the presence or amount of a complex comprising a first and second molecular entity are provided, preferably an sFlt-1:PlGF complex. A determination of the presence or amount of the complex can be used in methods for predicting, detecting, monitoring a disease, or guiding therapy in respect to a disease such as vascular, vascular-related disease, cardiac, cardiac-related disease, cancer, cancer-related disease, preeclampsia, and preeclampsia-related disease. Determining sFlt-1:angiogenic factor complex is particularly useful for predicting and detecting preeclampsia in early stages of gestation and in stages of the disease where clinical evaluation may be uninformative.

摘要翻译： 提供了确定包含第一和第二分子实体的复合物的存在或量的方法，优选为sFlt-1：PlGF复合物。 复合物的存在或量的确定可用于预测，检测，监测疾病或指导治疗相关疾病如血管，血管相关疾病，心脏，心脏相关疾病，癌症， 癌症相关疾病，先兆子痫和先兆子痫相关疾病。 测定sFlt-1：血管生成因子复合物特别可用于预测和检测妊娠早期阶段和疾病阶段的先兆子痫，其临床评估可能是不知情的。

公开(公告)号：US20090176247A1

公开(公告)日：2009-07-09

申请号：US12350090

申请日：2009-01-07

申请人： George Bashirians ,  Deborah Byrne ,  Sarah Groulx ,  Sharon Jackson ,  Heather Lane-Brown ,  Banumathi Sankaran ,  Edward Scalice ,  Karen Yang ,  Jian Zheng

发明人： George Bashirians ,  Deborah Byrne ,  Sarah Groulx ,  Sharon Jackson ,  Heather Lane-Brown ,  Banumathi Sankaran ,  Edward Scalice ,  Karen Yang ,  Jian Zheng

IPC分类号： G01N33/53 ,  G01N33/566

CPC分类号： G01N33/689 ,  G01N33/543 ,  G01N33/566 ,  G01N33/6872 ,  G01N2333/475 ,  G01N2333/515 ,  G01N2333/71 ,  G01N2333/91205 ,  G01N2800/368 ,  G01N2800/50 ,  G01N2800/56

摘要： Methods for determining the presence or amount of a complex comprising a first and second molecular entity are provided, preferably an sFlt-1:PlGF complex. A determination of the presence or amount of the complex can be used in methods for predicting, detecting, monitoring a disease, or guiding therapy in respect to a disease such as vascular, vascular-related disease, cardiac, cardiac-related disease, cancer, cancer-related disease, preeclampsia, and preeclampsia-related disease. Determining sFlt-1:angiogenic factor complex is particularly useful for predicting and detecting preeclampsia in early stages of gestation and in stages of the disease where clinical evaluation may be uninformative.

摘要翻译： 提供了确定包含第一和第二分子实体的复合物的存在或量的方法，优选为sFlt-1：PlGF复合物。 复合物的存在或量的确定可用于预测，检测，监测疾病或指导治疗相关疾病如血管，血管相关疾病，心脏，心脏相关疾病，癌症， 癌症相关疾病，先兆子痫和先兆子痫相关疾病。 测定sFlt-1：血管生成因子复合物特别可用于预测和检测妊娠早期阶段和疾病阶段的先兆子痫，其临床评估可能是不知情的。