公开(公告)号：US08835183B2

公开(公告)日：2014-09-16

申请号：US12350090

申请日：2009-01-07

申请人： George Bashirians ,  Deborah Byrne ,  Sarah Groulx ,  Sharon Jackson ,  Heather Lane-Brown ,  Banumathi Sankaran ,  Edward Scalice ,  Karen Yang ,  Jian Zheng

发明人： George Bashirians ,  Deborah Byrne ,  Sarah Groulx ,  Sharon Jackson ,  Heather Lane-Brown ,  Banumathi Sankaran ,  Edward Scalice ,  Karen Yang ,  Jian Zheng

IPC分类号： G01N33/543 ,  G01N33/68 ,  G01N33/566

CPC分类号： G01N33/689 ,  G01N33/543 ,  G01N33/566 ,  G01N33/6872 ,  G01N2333/475 ,  G01N2333/515 ,  G01N2333/71 ,  G01N2333/91205 ,  G01N2800/368 ,  G01N2800/50 ,  G01N2800/56

摘要： Methods for determining the presence or amount of a complex comprising a first and second molecular entity are provided, preferably an sFlt-1:PlGF complex. A determination of the presence or amount of the complex can be used in methods for predicting, detecting, monitoring a disease, or guiding therapy in respect to a disease such as vascular, vascular-related disease, cardiac, cardiac-related disease, cancer, cancer-related disease, preeclampsia, and preeclampsia-related disease. Determining sFlt-1:angiogenic factor complex is particularly useful for predicting and detecting preeclampsia in early stages of gestation and in stages of the disease where clinical evaluation may be uninformative.

摘要翻译： 提供了确定包含第一和第二分子实体的复合物的存在或量的方法，优选为sFlt-1：PlGF复合物。 复合物的存在或量的确定可用于预测，检测，监测疾病或指导治疗相关疾病如血管，血管相关疾病，心脏，心脏相关疾病，癌症， 癌症相关疾病，先兆子痫和先兆子痫相关疾病。 测定sFlt-1：血管生成因子复合物特别可用于预测和检测妊娠早期阶段和疾病阶段的先兆子痫，其临床评估可能是不知情的。

公开(公告)号：US20090176247A1

公开(公告)日：2009-07-09

申请号：US12350090

申请日：2009-01-07

申请人： George Bashirians ,  Deborah Byrne ,  Sarah Groulx ,  Sharon Jackson ,  Heather Lane-Brown ,  Banumathi Sankaran ,  Edward Scalice ,  Karen Yang ,  Jian Zheng

发明人： George Bashirians ,  Deborah Byrne ,  Sarah Groulx ,  Sharon Jackson ,  Heather Lane-Brown ,  Banumathi Sankaran ,  Edward Scalice ,  Karen Yang ,  Jian Zheng

IPC分类号： G01N33/53 ,  G01N33/566

CPC分类号： G01N33/689 ,  G01N33/543 ,  G01N33/566 ,  G01N33/6872 ,  G01N2333/475 ,  G01N2333/515 ,  G01N2333/71 ,  G01N2333/91205 ,  G01N2800/368 ,  G01N2800/50 ,  G01N2800/56

摘要： Methods for determining the presence or amount of a complex comprising a first and second molecular entity are provided, preferably an sFlt-1:PlGF complex. A determination of the presence or amount of the complex can be used in methods for predicting, detecting, monitoring a disease, or guiding therapy in respect to a disease such as vascular, vascular-related disease, cardiac, cardiac-related disease, cancer, cancer-related disease, preeclampsia, and preeclampsia-related disease. Determining sFlt-1:angiogenic factor complex is particularly useful for predicting and detecting preeclampsia in early stages of gestation and in stages of the disease where clinical evaluation may be uninformative.

摘要翻译： 提供了确定包含第一和第二分子实体的复合物的存在或量的方法，优选为sFlt-1：PlGF复合物。 复合物的存在或量的确定可用于预测，检测，监测疾病或指导治疗相关疾病如血管，血管相关疾病，心脏，心脏相关疾病，癌症， 癌症相关疾病，先兆子痫和先兆子痫相关疾病。 测定sFlt-1：血管生成因子复合物特别可用于预测和检测妊娠早期阶段和疾病阶段的先兆子痫，其临床评估可能是不知情的。

公开(公告)号：US08148157B2

公开(公告)日：2012-04-03

申请号：US12349695

申请日：2009-01-07

申请人： John W. Backus ,  Jian Zheng ,  George Bashirians

发明人： John W. Backus ,  Jian Zheng ,  George Bashirians

IPC分类号： G01N31/00

CPC分类号： G01N33/96 ,  G01N2496/80 ,  Y10T436/105831

摘要： Disclosed herein are compositions and methods comprising two or more proteins in which at least one of the proteins has been altered to reduce their mutual recognition and binding. Such compositions are useful as reference, calibrators or controls in methods and assays for determining the amount of one or more of the proteins that may be present in a sample of interest or in confirming the presence of one or more of the proteins in the sample. More particularly, it relates to compositions and methods comprising altered placental growth factor-1 (PlGF-1) and soluble fms-like tyrosine kinase (sFlt-1) and methods for determining the amount or confirming the presence of sFlt-1 and/or PlGF-1 in a sample of interest.

摘要翻译： 本文公开了包含两种或更多种蛋白质的组合物和方法，其中至少一种蛋白质已被改变以减少它们的相互识别和结合。 这样的组合物可用作用于测定可能存在于感兴趣样品中的一种或多种蛋白质的量的方法和测定中的参考，校准物或对照，或确认样品中一种或多种蛋白质的存在。 更具体地说，本发明涉及包含改变的胎盘生长因子-1（PlGF-1）和可溶性fms样酪氨酸激酶（sFlt-1）的组合物和方法以及用于确定量或确认sFlt-1和/或 PlGF-1在感兴趣的样本中。

公开(公告)号：US20120142035A1

公开(公告)日：2012-06-07

申请号：US13401263

申请日：2012-02-21

申请人： John W. Backus ,  Jian Zheng ,  George Bashirians

发明人： John W. Backus ,  Jian Zheng ,  George Bashirians

IPC分类号： G01N33/53

CPC分类号： G01N33/96 ,  G01N2496/80 ,  Y10T436/105831

摘要： Disclosed herein are compositions and methods comprising two or more proteins in which at least one of the proteins has been altered to reduce their mutual recognition and binding. Such compositions are useful as reference, calibrators or controls in methods and assays for determining the amount of one or more of the proteins that may be present in a sample of interest or in confirming the presence of one or more of the proteins in the sample. More particularly, it relates to compositions and methods comprising altered placental growth factor-1 (PlGF-1) and soluble fms-like tyrosine kinase (sFlt-1) and methods for determining the amount or confirming the presence of sFlt-1 and/or PlGF-1 in a sample of interest.

摘要翻译： 本文公开了包含两种或更多种蛋白质的组合物和方法，其中至少一种蛋白质已被改变以减少它们的相互识别和结合。 这样的组合物可用作用于测定可能存在于感兴趣样品中的一种或多种蛋白质的量的方法和测定中的参考，校准物或对照，或确认样品中一种或多种蛋白质的存在。 更具体地说，本发明涉及包含改变的胎盘生长因子-1（PlGF-1）和可溶性fms样酪氨酸激酶（sFlt-1）的组合物和方法以及用于确定量或确认sFlt-1和/或 PlGF-1在感兴趣的样本中。

公开(公告)号：US08940492B2

公开(公告)日：2015-01-27

申请号：US13401263

申请日：2012-02-21

申请人： John W. Backus ,  Jian Zheng ,  George Bashirians

发明人： John W. Backus ,  Jian Zheng ,  George Bashirians

IPC分类号： G01N33/53 ,  G01N33/96

CPC分类号： G01N33/96 ,  G01N2496/80 ,  Y10T436/105831

摘要： Disclosed herein are compositions and methods comprising two or more proteins in which at least one of the proteins has been altered to reduce their mutual recognition and binding. Such compositions are useful as reference, calibrators or controls in methods and assays for determining the amount of one or more of the proteins that may be present in a sample of interest or in confirming the presence of one or more of the proteins in the sample. More particularly, it relates to compositions and methods comprising altered placental growth factor-1 (PlGF-1) and soluble fms-like tyrosine kinase (sFlt-1) and methods for determining the amount or confirming the presence of sFlt-1 and/or PlGF-1 in a sample of interest.

摘要翻译： 本文公开了包含两种或更多种蛋白质的组合物和方法，其中至少一种蛋白质已被改变以减少它们的相互识别和结合。 这样的组合物可用作参考，校准物或对照，用于确定可能存在于感兴趣样品中的一种或多种蛋白质的量或用于确认样品中一种或多种蛋白质的存在的方法和测定中。 更具体地说，本发明涉及包含改变的胎盘生长因子-1（PlGF-1）和可溶性fms样酪氨酸激酶（sFlt-1）的组合物和方法以及用于确定量或确认sFlt-1和/或 PlGF-1在感兴趣的样本中。

公开(公告)号：US20090176264A1

公开(公告)日：2009-07-09

申请号：US12349695

申请日：2009-01-07

申请人： John W. Backus ,  Jian Zheng ,  George Bashirians

发明人： John W. Backus ,  Jian Zheng ,  George Bashirians

IPC分类号： C12Q1/48

CPC分类号： G01N33/96 ,  G01N2496/80 ,  Y10T436/105831

摘要： Disclosed herein are compositions and methods comprising two or more proteins in which at least one of the proteins has been altered to reduce their mutual recognition and binding. Such compositions are useful as reference, calibrators or controls in methods and assays for determining the amount of one or more of the proteins that may be present in a sample of interest or in confirming the presence of one or more of the proteins in the sample. More particularly, it relates to compositions and methods comprising altered placental growth factor-1 (PlGF-1) and soluble fms-like tyrosine kinase (sFlt-1) and methods for determining the amount or confirming the presence of sFlt-1 and/or PlGF-1 in a sample of interest.

摘要翻译： 本文公开了包含两种或更多种蛋白质的组合物和方法，其中至少一种蛋白质已被改变以减少它们的相互识别和结合。 这样的组合物可用作用于测定可能存在于感兴趣样品中的一种或多种蛋白质的量的方法和测定中的参考，校准物或对照，或确认样品中一种或多种蛋白质的存在。 更具体地说，本发明涉及包含改变的胎盘生长因子-1（PlGF-1）和可溶性fms样酪氨酸激酶（sFlt-1）的组合物和方法以及用于确定量或确认sFlt-1和/或 PlGF-1在感兴趣的样本中。

公开(公告)号：US09034894B2

公开(公告)日：2015-05-19

申请号：US14124570

申请日：2012-06-15

申请人： Yang Wang ,  Xiufeng Yan ,  Lijia Jing ,  Weimin Ding ,  Jian Zheng ,  Qiuying Pang ,  Tao Yu

发明人： Yang Wang ,  Xiufeng Yan ,  Lijia Jing ,  Weimin Ding ,  Jian Zheng ,  Qiuying Pang ,  Tao Yu

IPC分类号： C07D491/22

CPC分类号： C07D491/22

摘要： Provided is a 10-methoxycamptothecine derivate of formula (1), wherein R is selected from hydrogen, C1-6 alkyl, C1-6 haloalkyl, aryl substituted C1-6 alkyl, phosphate substituted C1-6 alkyl, amino-substituted C1-6 alkyl, carboxyl substituted C1-6 alkyl, hydroxyl substituted C1-6 alkyl, and amide-substituted C1-6 alkyl; R1 is selected from hydrogen and t-butoxycarbonyl substituted amino. Also provided in the present invention are the preparation method of the derivate and the use thereof in anti-tumor drug preparation.

摘要翻译： 提供式（1）的10-甲氧基喜树碱衍生物，其中R选自氢，C 1-6烷基，C 1-6卤代烷基，芳基取代的C 1-6烷基，磷酸酯取代的C 1-6烷基，氨基取代的C 1-6 烷基，羧基取代的C 1-6烷基，羟基取代的C 1-6烷基和酰胺取代的C 1-6烷基; R1选自氢和叔丁氧基羰基取代的氨基。 本发明还提供了其在抗肿瘤药物制备中的衍生及其用途的制备方法。

公开(公告)号：US08969229B2

公开(公告)日：2015-03-03

申请号：US12445685

申请日：2007-10-22

申请人： Philip Alexander Barrett ,  Neil Andrew Stephenson ,  Steven John Pontonio ,  Jian Zheng

发明人： Philip Alexander Barrett ,  Neil Andrew Stephenson ,  Steven John Pontonio ,  Jian Zheng

IPC分类号： B01J35/10 ,  B01J29/06 ,  B01J29/18 ,  B01J20/12 ,  B01J20/30 ,  B01D53/02 ,  B01D53/04 ,  B01D53/047 ,  B01J20/18 ,  B01J20/28

CPC分类号： B01J20/305 ,  B01D53/02 ,  B01D53/04 ,  B01D53/047 ,  B01D2253/108 ,  B01D2253/30 ,  B01J20/12 ,  B01J20/183 ,  B01J20/186 ,  B01J20/28019 ,  B01J20/2803 ,  B01J20/28085 ,  B01J20/3042

摘要： The present invention generally relates to high rate adsorbents and a method for their manufacture involving the steps of component mixing, extrusion, spheronization and calcination. The component mixing can involve both dry mixing in addition to wet mixing of an adsorbent with a binder, if required, and a fluid such as water. The paste so formed from the mixing stage is extruded to produce pellets which are optionally converted to beads by spheronization using in one embodiment, a marumerizer. The product is harvested and calcined to set any binder or binders used and/or burn out any additives or processing aids. This basic manufacturing scheme can be augmented by extra processing steps including ion exchange and activation to alter the composition of the adsorbents, as required.

摘要翻译： 本发明一般涉及高速吸附剂及其制造方法，包括组分混合，挤出，滚圆和煅烧的步骤。 除了吸附剂与粘合剂的湿混合之外，如果需要，以及诸如水的流体，组分混合可以包括干混合。 将从混合阶段形成的浆料被挤出以产生颗粒，其通过在一个实施方案中使用丸算机，通过滚圆法任选地转化为珠粒。 收获产品并煅烧以设置所使用的任何粘合剂或粘合剂和/或燃烧任何添加剂或加工助剂。 可以根据需要通过额外的加工步骤来增加该基本制造方案，包括离子交换和活化以改变吸附剂的组成。

公开(公告)号：US08769548B2

公开(公告)日：2014-07-01

申请号：US13620369

申请日：2012-09-14

申请人： Antti Piira ,  Rishit Shah ,  Rupen Chanda ,  Gavin Peacock ,  Jian Zheng ,  Brent Getlin ,  Thomas Reilly

发明人： Antti Piira ,  Rishit Shah ,  Rupen Chanda ,  Gavin Peacock ,  Jian Zheng ,  Brent Getlin ,  Thomas Reilly

IPC分类号： G06F3/00 ,  G05F1/70 ,  G06F1/32 ,  G06F9/48 ,  G06F9/50

CPC分类号： G06F9/485 ,  G06F1/329 ,  G06F9/5022 ,  G06F2209/504 ,  G06F2209/508 ,  Y02D10/22 ,  Y02D10/24

摘要： Techniques and systems are disclosed for managing computer resources available to multiple running instances of a media player program. The methods include monitoring consumption of computing resources of multiple running instances of a media player program to render respective media content in a graphical user interface of a computing device. The graphical user interface associated with an additional program configured to render additional content, different from the media content, to the graphical user interface. The additional program can be a browser. The methods further include instructing the multiple instances to reduce respective portions of the computing resources consumption upon determining that a requested increase in computer resources consumption of the media player program would cause the computer resources consumption of the media player program to exceed a first predetermined level.

摘要翻译： 公开了用于管理可用于媒体播放器程序的多个运行实例的计算机资源的技术和系统。 这些方法包括监视媒体播放器程序的多个运行实例的计算资源的消耗，以在计算设备的图形用户界面中呈现相应的媒体内容。 与附加程序相关联的图形用户界面被配置为向图形用户界面呈现不同于媒体内容的附加内容。 附加程序可以是浏览器。 所述方法还包括指示多个实例在确定所请求的媒体播放器节目的计算机资源消耗的增加将导致媒体播放器节目的计算机资源消耗超过第一预定水平时减少计算资源消耗的各个部分。

公开(公告)号：US08663943B2

公开(公告)日：2014-03-04

申请号：US12172787

申请日：2008-07-14

申请人： Jian Zheng ,  Steve Stanley Alexander

发明人： Jian Zheng ,  Steve Stanley Alexander

IPC分类号： G01N33/68

CPC分类号： G01N33/6896 ,  A61K2039/505 ,  C07K16/2872 ,  C07K16/44 ,  G01N33/5308 ,  G01N2800/2828

摘要： In the present invention, we described the use of anti-DNA antibody for the detection of prions and diagnosis of Transmissible Spongiform Encephalopathies (TSE) diseases in animals and humans.

摘要翻译： 在本发明中，我们描述了抗DNA抗体在动物和人类中检测朊病毒和诊断传染性海绵状脑病（TSE）疾病的用途。