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公开(公告)号：US07435870B2
公开(公告)日：2008-10-14
申请号：US11280849
申请日：2005-11-15
IPC分类号： A61K49/00 , G01N33/00 , A01K67/00 , A01K67/033 , A01K67/027
CPC分类号： C12N15/8509 , A01K2217/05 , A01K2227/40 , A01K2267/0393 , A61K49/0004 , A61K49/0008 , A61K49/006 , C12Q1/68 , C12Q1/6809 , C12Q1/6888 , C12Q2600/136 , C12Q2600/142 , C12Q2600/158 , G01N33/5014 , G01N33/5088 , G01N2333/4603 , G01N2510/00 , C12Q2565/501
摘要： The present invention provides methods of screening an agent for activity using teleosts. Methods of screening an agent for angiogenesis activity, toxic activity and an effect cell death activity in teleosts are provided.
摘要翻译： 本发明提供了使用硬骨架筛选活性剂的方法。 提供了在硬骨鱼中筛选药物血管生成活性，毒性活性和影响细胞死亡活性的方法。
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公开(公告)号：US07041276B2
公开(公告)日：2006-05-09
申请号：US09947635
申请日：2001-09-05
IPC分类号： A61K49/00 , A61B10/00 , A61B5/00 , A61B8/00 , A01K67/027
CPC分类号： C12N15/8509 , A01K2217/05 , A01K2227/40 , A01K2267/0393 , A61K49/0004 , A61K49/0008 , A61K49/006 , C12Q1/68 , C12Q1/6809 , C12Q1/6888 , C12Q2600/136 , C12Q2600/142 , C12Q2600/158 , G01N33/5014 , G01N33/5088 , G01N2333/4603 , G01N2510/00 , C12Q2565/501
摘要： The present invention provides methods of screening an agent for activity using teleosts. Methods of screening an agent for angiogenesis activity, toxic activity and an effect cell death activity in teleosts are provided.
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公开(公告)号：US06299858B1
公开(公告)日：2001-10-09
申请号：US09255397
申请日：1999-02-22
IPC分类号： A61K4900
CPC分类号： C12N15/8509 , A01K2217/05 , A01K2227/40 , A01K2267/0393 , A61K49/0004 , A61K49/0008 , A61K49/006 , C12Q1/68 , C12Q1/6809 , C12Q1/6888 , C12Q2600/136 , C12Q2600/142 , C12Q2600/158 , G01N33/5014 , G01N33/5088 , G01N2333/4603 , G01N2510/00 , C12Q2565/501
摘要： The present invention provides methods of screening an agent for activity using teleosts. Methods of screening an agent for angiogenesis activity, toxic activity and an effect cell death activity in teleosts are provided.
摘要翻译： 本发明提供了使用硬骨架筛选活性剂的方法。 提供了在硬骨鱼中筛选药物血管生成活性，毒性活性和影响细胞死亡活性的方法。
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公开(公告)号：US20060104905A1
公开(公告)日：2006-05-18
申请号：US11280849
申请日：2005-11-15
申请人： George Serbedzija , Carlos Semino , Deanna Frost
发明人： George Serbedzija , Carlos Semino , Deanna Frost
IPC分类号： C12Q1/68 , A61K49/00 , A01K67/027
CPC分类号： C12N15/8509 , A01K2217/05 , A01K2227/40 , A01K2267/0393 , A61K49/0004 , A61K49/0008 , A61K49/006 , C12Q1/68 , C12Q1/6809 , C12Q1/6888 , C12Q2600/136 , C12Q2600/142 , C12Q2600/158 , G01N33/5014 , G01N33/5088 , G01N2333/4603 , G01N2510/00 , C12Q2565/501
摘要： The present invention provides methods of screening an agent for activity using teleosts. Methods of screening an agent for angiogenesis activity, toxic activity and an effect cell death activity in teleosts are provided.
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公开(公告)号：US20060123487A1
公开(公告)日：2006-06-08
申请号：US11320251
申请日：2005-12-27
申请人： George Serbedzija , Carlos Semino , Deanna Frost
发明人： George Serbedzija , Carlos Semino , Deanna Frost
IPC分类号： A01K67/027
CPC分类号： A61K49/0008 , A01K2217/05 , A01K2227/40 , A01K2267/035 , A01K2267/0393 , A61K49/0021 , C12N15/8509 , G01N33/5014 , G01N33/5088 , G01N2333/4603 , G01N2510/00
摘要： The present invention provides methods of screening an agent for activity using teleosts. Methods of screening an agent for angiogenesis activity, toxic activity and an effect cell death activity in teleosts are provided. The invention further provides high throughput methods of screening agents in multi-well plates.
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公开(公告)号：US20050188426A1
公开(公告)日：2005-08-25
申请号：US11114712
申请日：2005-04-25
申请人： George Serbedzija , Carlos Semino , Deanna Frost
发明人： George Serbedzija , Carlos Semino , Deanna Frost
IPC分类号： A61K49/00 , C12N15/85 , G01N33/50 , A01K67/027 , C12Q1/68
CPC分类号： A61K49/0008 , A01K2217/05 , A01K2227/40 , A01K2267/035 , A01K2267/0393 , A61K49/0021 , C12N15/8509 , G01N33/5014 , G01N33/5088 , G01N2333/4603 , G01N2510/00
摘要： The present invention provides methods of screening an agent for activity using teleosts. Methods of screening an agent for angiogenesis activity, toxic activity and an effect cell death activity in teleosts are provided. The invention further provides high throughput methods of screening agents in multi-well plates.
摘要翻译： 本发明提供了使用硬骨架筛选活性剂的方法。 提供了在硬骨鱼中筛选药物血管生成活性，毒性活性和影响细胞死亡活性的方法。 本发明还提供了多孔板中筛选剂的高通量方法。
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