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    Self-assembling peptides incorporating modifications and methods of use thereof
    2.
    发明申请
    Self-assembling peptides incorporating modifications and methods of use thereof 有权
    包含修饰的自组装肽及其使用方法

    公开(公告)号：US20050181973A1

    公开(公告)日：2005-08-18

    申请号：US10877068

    申请日：2004-06-25

    申请人： Elsa Genove ,  Shuguang Zhang ,  Carlos Semino

    发明人： Elsa Genove ,  Shuguang Zhang ,  Carlos Semino

    IPC分类号： A61K38/17 ,  C07K14/47 ,  C12N5/02 ,  C12N5/08 ,  C12P21/06

    CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K7/06 ,  C07K14/78 ,  C07K2319/735

    摘要： The invention provides a self-assembling peptide comprising (a) a first amino acid domain that mediates self-assembly, wherein the domain comprises alternating hydrophobic and hydrophilic amino acids that are complementary and structurally compatible and self-assemble into a macroscopic structure when present in unmodified form; and (b) a second amino acid domain that does not self-assemble in isolated form. In certain embodiments of the invention the second amino acid domain comprises a biologically active peptide motif, e.g., a peptide motif found in a naturally occurring protein, or a target site for an interaction with a biomolecule. In certain embodiments of the invention the naturally occurring protein is a component of the extracellular matrix, e.g., a component of the basement membrane. The invention further provides scaffolds comprising the self-assembling peptides and methods of using the scaffolds including for cell culture, tissue engineering, and tissue repair.

    摘要翻译： 本发明提供了一种自组装肽，其包含（a）介导自组装的第一氨基酸结构域，其中所述结构域包含互补和结构相容的交替的疏水性和亲水性氨基酸，并且如果存在于，将其自组装成宏观结构 未经修改的形式; 和（b）不以分离形式自组装的第二个氨基酸结构域。 在本发明的某些实施方案中，第二氨基酸结构域包含生物活性肽基序，例如在天然存在的蛋白质中发现的肽基序，或与生物分子相互作用的靶位点。 在本发明的某些实施方案中，天然存在的蛋白质是细胞外基质的组分，例如基底膜的组分。 本发明还提供了包含自组装肽的支架和使用支架的方法，包括用于细胞培养，组织工程和组织修复。

    SELF-ASSEMBLING PEPTIDE INCORPORATING MODIFICATIONS AND METHODS OF USE THEREOF
    4.
    发明申请
    SELF-ASSEMBLING PEPTIDE INCORPORATING MODIFICATIONS AND METHODS OF USE THEREOF 有权
    自组装肽的修改及其使用方法

    公开(公告)号：US20100311640A1

    公开(公告)日：2010-12-09

    申请号：US12724153

    申请日：2010-03-15

    申请人： Elsa Genove ,  Shuguang Zhang ,  Carlos Semino

    发明人： Elsa Genove ,  Shuguang Zhang ,  Carlos Semino

    IPC分类号： A61K38/02 ,  C07K2/00 ,  C07K14/00 ,  C12N5/00 ,  A61P35/00 ,  A61P13/12 ,  C07K7/08 ,  C07K7/06 ,  C07K5/10 ,  C07K5/08

    CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K7/06 ,  C07K14/78 ,  C07K2319/735

    摘要： The invention provides a self-assembling peptide comprising (a) a first amino acid domain that mediates self-assembly, wherein the domain comprises alternating hydrophobic and hydrophilic amino acids that are complementary and structurally compatible and self-assemble into a macroscopic structure when present in unmodified form; and (b) a second amino acid domain that does not self-assemble in isolated form. In certain embodiments of the invention the second amino acid domain comprises a biologically active peptide motif, e.g., a peptide motif found in a naturally occurring protein, or a target site for an interaction with a biomolecule. In certain embodiments of the invention the naturally occurring protein is a component of the extracellular matrix, e.g., a component of the basement membrane. The invention further provides scaffolds comprising the self-assembling peptides and methods of using the scaffolds including for cell culture, tissue engineering, and tissue repair.

    摘要翻译： 本发明提供一种自组装肽，其包含（a）介导自组装的第一氨基酸结构域，其中所述结构域包含互补和结构相容的交替的疏水性和亲水性氨基酸，并且当存在于 未经修改的形式; 和（b）不以分离形式自组装的第二个氨基酸结构域。 在本发明的某些实施方案中，第二氨基酸结构域包含生物活性肽基序，例如在天然存在的蛋白质中发现的肽基序，或与生物分子相互作用的靶位点。 在本发明的某些实施方案中，天然存在的蛋白质是细胞外基质的组分，例如基底膜的组分。 本发明还提供了包含自组装肽的支架和使用支架的方法，包括用于细胞培养，组织工程和组织修复。

    Self-assembling peptides incorporating modifications and methods of use thereof
    6.
    发明授权
    Self-assembling peptides incorporating modifications and methods of use thereof 有权
    包含修饰的自组装肽及其使用方法

    公开(公告)号：US07713923B2

    公开(公告)日：2010-05-11

    申请号：US10877068

    申请日：2004-06-25

    申请人： Elsa Genove ,  Shuguang Zhang ,  Carlos Semino

    发明人： Elsa Genove ,  Shuguang Zhang ,  Carlos Semino

    IPC分类号： A61K38/00

    CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K7/06 ,  C07K14/78 ,  C07K2319/735

    摘要： The invention provides a self-assembling peptide comprising (a) a first amino acid domain that mediates self-assembly, wherein the domain comprises alternating hydrophobic and hydrophilic amino acids that are complementary and structurally compatible and self-assemble into a macroscopic structure when present in unmodified form; and (b) a second amino acid domain that does not self-assemble in isolated form. In certain embodiments of the invention the second amino acid domain comprises a biologically active peptide motif, e.g., a peptide motif found in a naturally occurring protein, or a target site for an interaction with a biomolecule. In certain embodiments of the invention the naturally occurring protein is a component of the extracellular matrix, e.g., a component of the basement membrane. The invention further provides scaffolds comprising the self-assembling peptides and methods of using the scaffolds including for cell culture, tissue engineering, and tissue repair.

    摘要翻译： 本发明提供了一种自组装肽，其包含（a）介导自组装的第一氨基酸结构域，其中所述结构域包含互补和结构相容的交替的疏水性和亲水性氨基酸，并且如果存在于，将其自组装成宏观结构 未经修改的形式; 和（b）不以分离形式自组装的第二个氨基酸结构域。 在本发明的某些实施方案中，第二氨基酸结构域包含生物活性肽基序，例如在天然存在的蛋白质中发现的肽基序，或与生物分子相互作用的靶位点。 在本发明的某些实施方案中，天然存在的蛋白质是细胞外基质的组分，例如基底膜的组分。 本发明还提供了包含自组装肽的支架和使用支架的方法，包括用于细胞培养，组织工程和组织修复。

    Self-assembling peptide incorporating modifications and methods of use thereof
    7.
    发明授权
    Self-assembling peptide incorporating modifications and methods of use thereof 有权
    包含修饰物和使用方法的自组装肽

    公开(公告)号：US08901084B2

    公开(公告)日：2014-12-02

    申请号：US12724153

    申请日：2010-03-15

    申请人： Elsa Genove ,  Shuguang Zhang ,  Carlos Semino

    发明人： Elsa Genove ,  Shuguang Zhang ,  Carlos Semino

    IPC分类号： A61K38/00 ,  C07K14/78

    CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K7/06 ,  C07K14/78 ,  C07K2319/735

    摘要： The invention provides a self-assembling peptide comprising (a) a first amino acid domain that mediates self-assembly, wherein the domain comprises alternating hydrophobic and hydrophilic amino acids that are complementary and structurally compatible and self-assemble into a macroscopic structure when present in unmodified form; and (b) a second amino acid domain that does not self-assemble in isolated form. In certain embodiments of the invention the second amino acid domain comprises a biologically active peptide motif, e.g., a peptide motif found in a naturally occurring protein, or a target site for an interaction with a biomolecule. In certain embodiments of the invention the naturally occurring protein is a component of the extracellular matrix, e.g., a component of the basement membrane. The invention further provides scaffolds comprising the self-assembling peptides and methods of using the scaffolds including for cell culture, tissue engineering, and tissue repair.

    摘要翻译： 本发明提供了一种自组装肽，其包含（a）介导自组装的第一氨基酸结构域，其中所述结构域包含互补和结构相容的交替的疏水性和亲水性氨基酸，并且如果存在于，将其自组装成宏观结构 未经修改的形式; 和（b）不以分离形式自组装的第二个氨基酸结构域。 在本发明的某些实施方案中，第二氨基酸结构域包含生物活性肽基序，例如在天然存在的蛋白质中发现的肽基序，或与生物分子相互作用的靶位点。 在本发明的某些实施方案中，天然存在的蛋白质是细胞外基质的组分，例如基底膜的组分。 本发明还提供了包含自组装肽的支架和使用支架的方法，包括用于细胞培养，组织工程和组织修复。