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公开(公告)号：US07230087B2
公开(公告)日：2007-06-12
申请号：US11171085
申请日：2005-06-29
IPC分类号： C07K16/00 , A61K39/395 , A61K39/40 , G01N33/53
CPC分类号： C07K16/1214 , A61K39/00 , A61K2039/505 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to P. aeruginosa mucoid exopolysaccharide. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of P. aeruginosa infection and related disorders (e.g., cystic fibrosis). Some antibodies of the invention enhance opsonophagocytic killing of multiple mucoid strains of P. aeruginosa. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
摘要翻译： 本发明涉及特异性结合铜绿假单胞菌粘液样多糖的肽，特别是人单克隆抗体。 本发明进一步提供了在诊断，预防和治疗铜绿假单胞菌感染和相关病症（例如囊性纤维化）中使用这些肽的方法。 本发明的一些抗体增强了对铜绿假单胞菌的多个粘液样菌株的调理吞噬性杀伤。 还提供了这些肽的组合物，包括药物组合物，以及这些肽的功能上等同的变体。
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公开(公告)号：US06962813B2
公开(公告)日：2005-11-08
申请号：US10153437
申请日：2002-05-21
CPC分类号： C07K16/1214 , A61K39/00 , A61K2039/505 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to P. aeruginosa mucoid exopolysaccharide. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of P. aeruginosa infection and related disorders (e.g., cystic fibrosis). Some antibodies of the invention enhance opsonophagocytic killing of multiple mucoid strains of P. aeruginosa. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
摘要翻译： 本发明涉及特异性结合铜绿假单胞菌粘液样多糖的肽，特别是人单克隆抗体。 本发明进一步提供了在诊断，预防和治疗铜绿假单胞菌感染和相关病症（例如囊性纤维化）中使用这些肽的方法。 本发明的一些抗体增强了对铜绿假单胞菌的多个粘液样菌株的调理吞噬性杀伤。 还提供了这些肽的组合物，包括药物组合物，以及这些肽的功能上等同的变体。
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公开(公告)号：US07119172B2
公开(公告)日：2006-10-10
申请号：US10440522
申请日：2003-05-16
IPC分类号： C07K14/00 , C07K16/00 , G01N33/53 , A61K39/395
CPC分类号： C07K16/1214 , A61K39/00 , A61K2039/505 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to P. aeruginosa mucoid exopolysaccharide. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of P. aeruginosa infection and related disorders (e.g., cystic fibrosis). Some antibodies of the invention enhance opsonophagocytic killing of multiple mucoid strains of P. aeruginosa. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
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公开(公告)号：US5511881A
公开(公告)日：1996-04-30
申请号：US369622
申请日：1995-01-06
CPC分类号： B01F7/1635
摘要： A rotatably driveable enhanced-flow impeller system is provided for pumping at least one liquid in a tank through an outlet port thereof. A radial flow impeller has a first impeller face disposed proximate the bottom of the tank and proximate or extending into an inlet port for liquids in the tank bottom. The radial flow impeller has a plurality of blades with radially outermost blade tips terminating along a blade terminating circle. Disposed adjacent a second opposing face of the radial flow impeller is a radial flow extension plate which preferably extends radially outwardly along the second face by a radial distance beyond the blade terminating circle. The radial flow extension plate may be fixedly attached to the second impeller face. The enhanced-flow impeller system can be used advantageously in conjunction with an axial flow impeller disposed on a common drive shaft in an upper portion of the tank, to form with enhanced effectiveness a liquid--liquid dispersion as droplets of at least one liquid in at least one other immiscible liquid and to distribute the dispersion uniformly through the tank volume during a dispersion residence time in the tank.
摘要翻译： 提供了一种可旋转驱动的增强流动叶轮系统，用于通过其出口泵送至少一个罐中的液体。 径向流动叶轮具有靠近罐的底部设置的第一叶轮面，并且靠近或延伸到用于罐底部中的液体的入口。 径向流动叶轮具有多个叶片，其具有沿刀片终止圆终止的径向最外侧的叶片尖端。 径向流动叶轮邻近第二相对面设置的是径向流动延伸板，其优选地沿第二面径向向外延伸超过叶片终止圆的径向距离。 径向延伸板可以固定地附接到第二叶轮面。 增强流动叶轮系统可以有利地与设置在罐的上部中的公共驱动轴上的轴流式叶轮结合使用，以增强的效果形成液体 - 液体分散体，作为液滴中的至少一种液体 至少一种其他不混溶的液体，并且在分散体停留时间期间将分散体均匀地分布在罐体积中。
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