公开(公告)号：US06962717B1

公开(公告)日：2005-11-08

申请号：US09890104

申请日：1999-01-29

申请人： Gerald Huber ,  Peter Gruber

发明人： Gerald Huber ,  Peter Gruber

IPC分类号： A61K9/32 ,  A61K9/00 ,  A61K9/02 ,  A61K9/16 ,  A61K9/20 ,  A61K9/26 ,  A61K9/28 ,  A61K9/48 ,  A61K9/50 ,  A61K9/52 ,  A61K31/135 ,  A61K31/485 ,  A61K31/606 ,  A61K47/32 ,  A61K47/38 ,  A61P25/04 ,  A61P29/00 ,  A61K9/14 ,  A61K9/22 ,  A61K9/46

CPC分类号： A61K9/2081 ,  A61K9/1635 ,  A61K9/5026 ,  A61K9/5073

摘要： A pharmaceutical composition for slow release of active ingredient in the gastrointestinal tract, comprising a plurality of active ingredient-containing particles coated with a material insoluble in gastric and intestinal juices, where the particles have as core a homogeneous mixture comprising an active pharmaceutical ingredient and a polymer insoluble in gastric and intestinal juices, with an average internal pore diameter not exceeding 35 μm, makes efficient and pH-independent delaying of release possible even with comparatively small amounts of polymer. It is additionally distinguished by a long shelf life and is particularly suitable also for nonspherical particles.

摘要翻译： 一种用于在胃肠道中缓慢释放活性成分的药物组合物，其包含多种含有不溶于胃和肠液的材料的活性成分颗粒，其中颗粒具有包含活性药物成分和 不溶于胃肠液的聚合物，平均内孔径不超过35μm，即使使用相对少量的聚合物也能有效且不依赖于pH的延迟释放。 另外由于保质期长，特别适用于非球形颗粒。

公开(公告)号：US20050123612A1

公开(公告)日：2005-06-09

申请号：US10499783

申请日：2001-12-21

申请人： Cornelis Sobel ,  Gerald Huber

发明人： Cornelis Sobel ,  Gerald Huber

IPC分类号： A61K9/16 ,  A61K31/7056 ,  A61P31/12 ,  A61K38/21 ,  B29B9/00

CPC分类号： A61K9/1652 ,  A61K9/1635

摘要： The present invention relates to a method for the production of a ribavirin-containing granulate, comprising the production of a granulate solution, comprising mixing of a binding agent with an isopropanol/water- or ethanol/water-mixture, stirring of the granulate solution into a mixture of ribavirin-powder with a hydrophilic or swellable solid adjuvant, and sieving and drying the so-obtained granulate, which is characterised in that the portion of isopropanol or ethanol of the alcohol/water-mixture is between 65% to 85% by weight. Based on this granulate, a ribavirin-tablet can be produced that can be used for the treatment of diseases, such as HCV.

摘要翻译： 本发明涉及一种生产含利巴韦林颗粒的方法，包括制备颗粒溶液，包括将结合剂与异丙醇/水或乙醇/水混合物混合，将颗粒溶液搅拌至 利巴韦林粉末与亲水性或溶胀性固体佐剂的混合物，并对所得颗粒进行筛分和干燥，其特征在于醇/水混合物的异丙醇或乙醇部分为65％至85％之间，通过 重量。 基于该颗粒，可以制备可用于治疗诸如HCV的疾病的利巴韦林片。

公开(公告)号：US07213799B2

公开(公告)日：2007-05-08

申请号：US10386520

申请日：2003-03-13

申请人： Christof Behmenburg ,  Heinz Job ,  Michael Märtens ,  Volker Härtel ,  Gerald Huber ,  Armin Kilsch ,  Thomas Engelke ,  Burkhard Kott

发明人： Christof Behmenburg ,  Heinz Job ,  Michael Märtens ,  Volker Härtel ,  Gerald Huber ,  Armin Kilsch ,  Thomas Engelke ,  Burkhard Kott

IPC分类号： F16F9/04

CPC分类号： B60G17/0521 ,  F16F9/0454 ,  F16F9/0472 ,  F16F9/05 ,  F16F9/055

摘要： A pneumatic suspension and damping arrangement (100) is fixedly mounted on the chassis at the upper region and to the wheel mount at the lower region thereof. The arrangement includes two hermetically closed air springs (101, 102) filled with pressurized gas, whose volumes can be changed and which are connected via an air connection (134) to a pressurized gas source. The air springs are each enclosed by a movable wall formed by a flexible member (116, 124) and each roll off on a roll-off contour and are connected to each other via a throttle element (108) through which the gas can flow in two directions. The air springs are arranged one above the other and the roll-off contour of the first air spring (101) is defined in such a way by the second air spring (102) that the first air spring (101) rolls off on the second air spring (102). A connecting element of the upper cover (104) ) with the roll-off piston (128) of the second air spring (102) runs outside of the two air springs (101, 102).

摘要翻译： 气动悬挂和阻尼装置（100）固定地安装在底盘上的上部区域和其下部的车轮安装座上。 该装置包括两个充满加压气体的气密密封空气弹簧（101,102），其容积可以改变，并且经由空气连接（134）连接到加压气体源。 空气弹簧各自由可挠性壁（116,124）形成的可动壁围绕，并且每个滚轮在滚降轮廓上滚动并通过节气门元件（108）彼此连接，气体可以通过该节流元件 两个方向 空气弹簧彼此并排布置，第一空气弹簧（101）的滚降轮廓由第二空气弹簧（102）限定，第一空气弹簧（101）在第二空气弹簧 空气弹簧（102）。 上盖（104）的连接元件与第二空气弹簧（102）的滚降活塞（128）一起延伸到两个空气弹簧（101,102）的外部。

公开(公告)号：US4389546A

公开(公告)日：1983-06-21

申请号：US246733

申请日：1981-03-23

申请人： David Glisson ,  Gerald Huber ,  Bruce Biskey

发明人： David Glisson ,  Gerald Huber ,  Bruce Biskey

IPC分类号： H04M3/487 ,  H04M3/53 ,  H04M3/50 ,  H04M15/00

CPC分类号： H04M3/4872 ,  H04M3/53

摘要： An automatic message, time and temperature announcement system wherein the signals to be announced are stored in digitized form in a random access memory (32). Under control of a CPU (15), blocks of digitized speech signals are provided to a FIFO (35) and from there to a CVSD digital to analog converter (37), the output of which is coupled (41) to a plurality of telephone trunks (42). A digital counter timer peripheral (26) is used to maintain a count of the time of day (32) and the frequency output (49) of a voltage to frequency converter (48) connected to a temperature sensor (40). Loading of digitized speech signals, correction factors for time of day, and other controls may be accomplished remotely through a data link (27, 30) from a standard voice grade telephone line (31).

摘要翻译： 一种自动消息，时间和温度公告系统，其中要发布的信号以数字形式存储在随机存取存储器（32）中。 在CPU（15）的控制下，数字化语音信号块被提供给FIFO（35），并从那里提供到CVSD数模转换器（37），其输出端耦合（41）到多个电话 树干（42）。 数字计数器计时器外围设备（26）用于维持连接到温度传感器（40）的电压到频率转换器（48）的时间（32）和频率输出（49）的计数。 可以通过来自标准话音级电话线路（31）的数据链路（27,30）远程地完成数字化语音信号的加载，时间的校正因子和其他控制。